ABSTRACT
@#AIM: To assess clinical efficacy of vitrectomy combined with heavy silicone oil tamponaded for severe proliferative vitreous retinopathy. <p>METHODS: Totally 13 severe proliferative vitreous retinopathy(PVR)patients(13 eyes)admitted to our hospital between June 2012 and December 2015 were included. We analyzed the clinical efficacy of vitrectomy combined with heavy silicone oil tamponaded and heavy silicone oil removal combined with C<sub>3</sub>F<sub>8</sub> tamponaded at late phase for 13 patients. Heavy silicone oil removal of 13 patients were performed at 10 to 17wk after heavy silicone oil tamponaded. The patients were reviewed at 1-7d after vitrectomy combined with heavy silicone oil tamponaded, 1, 2, 4 and 17wk after hospital discharge, 1-7d after the heavy silicone oil removal, 1, 2, 4, 8, 12 and 24wk after the second hospital discharge. Patients were followed up for at least 24wk after the heavy silicone oil removal. The observed indicators included the rate of retinal reattachment, the best corrected visual acuity, intraocular pressure(IOP), intraocular lens and postoperative complications.<p>RESULTS: During follow-up,13 eyes showed a stably reattached after heavy silicone oil tamponaded. Heavy Silicone oil of 13 patients were removed combined with C<sub>3</sub>F<sub>8</sub> tamponaded for 10 to 17 wk after heavy silicone oil tamponaded. But the fifth case had retinal detachment recurrence for 4wk after heavy silicone oil removed because of macular hole and the eighth case had retinal detachment recurrence for 8wk after heavy silicone oil removed because of new superior temporal retinal hole. Follow up for 24wk, the other 11 eyes showed a stably reattached after heavy oil silicone removed. The best corrected visual acuity range of 13 eyes were in light perception to hand move before heavy oil silicone tamponaded and the best corrected visual acuity range of 13 eyes were in hand move to 20/250 for 24wk after heavy oil silicone removed. The best corrected visual acuity of the fifth case and the eighth case were count finger and hand move for 24wk after heavy oil silicone removed. Four eyes had high intraocular pressure 1wk after heavy oil silicone tamponaded which were reduced to 10-21mmHg after drug treatment. At late phase 5 eyes had drug uncontrollable high intraocular pressure which we took silicone oil removal timely. Three eyes had temporarily high intraocular pressure after heavy oil silicone removed which were reduced to 10-21mmHg after drug treatment. At late phase 3 eyes did not appear high intraocular pressure after stopping anti-glaucoma medication. Thirteen eyes had no serious complications such as anterior chamber inflammation and endophthalmitis during the treatment. <p>CONCLUSION: Vitrectomy combined with heavy silicone oil tamponaded and heavy oil silicone removed combined with C<sub>3</sub>F<sub>8</sub> tamponaded at late phase for 13 severe proliferative vitreous retinopathy patients could achieve a satisfactory rate of retinal reattachment and improve the patients' prognostic visual acuity.
ABSTRACT
AIM: To evaluate the therapeutic efficacy and safety of heavy silicone oil (HSO), Densiron 68, was used as internal tamponade to treat complex vitreoretinopathy.METHODS: A retrospective study of 30 patients (30 eyes) who underwent vitrectomy and HSO tamponade for complex retinal detachment between January 2015 and January 2016.The best corrected visual acuity (BCVA), intraocular pressure (IOP), retinal reattachment and complications after surgery were observed.RESULTS: There were statistical significances in both the BCVA difference between pre-operation and HSO tamponade, and the BCVA difference between pre-operation and the removal of HSO for 3mo (z=-2.198, P=0.028;z=-2.682, P=0.007).The average intraocular pressure of HSO tamponade group was 20.233±8.007mmHg, and the average intraocular pressure of pre-operation group was 16.067±4.025mmHg, showing significant difference(t=-2.913, P=0.005).Between the pre-operation group and the HSO removed group 14.933±3.423mmHg, there was no significant statistical difference in the analysis of IOP (t=2.635, P=0.430).Anatomical success was achieved in 90% of cases after the removal of HSO.Most common complications were cataract formation and oil emulsification.CONCLUSION: Densiron-68 is a safe and effective tamponade material for the treatment of complex vitreoretinopathy.However, most common complications are cataract formation and oil emulsification.So clinicians should strictly handle indications and usage during the clinical applications.
ABSTRACT
Aim: The intraocular silicone oil (SO) tamponades used in the treatment of retinal detachment (RD) have been associated with a difference ocular hypertension (OH) rate. To clarify, if this complication was associated to use of standard SO (SSO) versus heavy SO (HSO), we performed a systematic review and meta‑analysis of comparative study between two kind of SO (standard or light vs. heavy) for the treatment of RD and macular hole, without restriction to study design. Materials and Methods: The methodological quality of two randomized clinical trials (RCTs) were evaluated using the criteria given in the Cochrane Handbook for Systematic Reviews of Intervention, while three non‑RCTs were assessed with the Newcastle– Ottawa Scale and Strengthening the Reporting of Observational Studies in Epidemiology checklists. We calculated Mantel–Haenszel risk ratio (RR) with 95% confidence intervals (95% CIs). The primary outcome was the rate of patients with OH treated with SSO compared to HSO. Results: There were a higher number of rates of OH in HSO compared to SSO. This difference was statistically significant with the fixed effect model (Mantel–Haenszel RR; 1.55; 95% CI, 1.06–2.28; P = 0.02) while there was not significative difference with the random effect model (Mantel–Haenszel RR; 1.51; 95% CI, 0.98–2.33; P = 0.06). Conclusion: We noted a trend that points out a higher OH rate in HSO group compared to SSO, but this finding, due to the small size and variable design of studies, needs to be confirmed in well‑designed and large size RCTs.
ABSTRACT
Purpose: To conduct an in vitro experimental study comparing the effectiveness of conventional silicone oil and heavy silicone oil against endophthalmitis‑causing agents. Materials and Methods: The antimicrobial activity of conventional silicone oil (RS OIL 5000) and heavy silicone oil (heavySil 1500) was tested. The antimicrobial effects of both silicone oils were determined by the growing capability of the microorganism. Results: The number of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans decreased to zero levels at the second day of inoculation in heavy silicone oil. In conventional silicone oil, the microorganisms survived longer than in heavy silicone oil. Conclusion: Heavy silicone oil seems to be more effective than conventional silicone oil against endophthalmitis‑causing agents.
ABSTRACT
Objective:To assess the clinical setting of a heavy silicone oil tamponade(Densiron-68) for rhegmatogenous retinal detachment(RRD).Methods:Twenty-nine eyes of 29 consecutive patients were recruited between December 2007 and February 2009.Primary vitrectomy with Densiron-68 was used in all cases.Patients to be selected had two groups:one group had 18 cases,mean age was 72.5 years.These patients were impossible prone because of ages and body factors.Among these of 11 cases had macular holes and posterior pole part holes,another of 7 cases had many holes.Another group had 11 cases,mean age was 45.8 years.These patients with inferior complex rhegmatogenous retinal detachment with secondary proliferative vitreoretinopathy(PVR) were included.Besides one case of giant retinal tear with between 2 and 7 clock hours,among these of 7 cases had one or two scleral buckling procedure,or pars plana vitrectomy with oil endotamponade.But inferior recurrent retinal re-detachment appeared.Surgical techniques included pars plana vitrectomy,membrane peeling,heavy water application,endophotocoagulation,cryocoagulation,endotamponade et al.Results:1or 13-month follow up,mean 4.3-month.Densiron-68 removal with 25 cases was after operation of 2 months,and didn't remove of 4 cases.After Densiron-68 removal,majority showed a stable reattached retina without further interventions,while,in one or two patients,recurrent retinal re-detachment appeared during Densiron-68 removal.Some of patients had partly lens opacification or lens post-capsular opacification.Part of patients had ocular hypertension.Conclusion:With Densiron-68,high anatomical and functional success rates can be achieved with inferior complex rhegmatogenous retinal detachment.Heavy silicone oil tamponade improves inferior tamponade,and may be considered a new generation of intraocular tamponades.But there were a significant early emulsification.Despite adequate Densiron fills,emulsification necessitated its removal.