Clinical significance of platelets activation in patients with acute cerebral hemorrhage / 临床神经病学杂志

Objective To study the platelets activation in patients with acute cerebral hemorrhage and its significance in perihematoma edema.Methods 33 patients with cerebral hemorrhage were treated with minimally invasive surgery.The volume of edema perihematoma was determined by CT technique before operation.The expressions of platelets CD62p and TSP in intracerebral hematoma fluid and venous blood were detected by flow cytometry(FCM).The correlation between the two variables was also analyzed.Results The expressions of platelets CD62p and TSP were higher in patients with acute cerebral hemorrhage than those in healthy individuals,and the expressions of platelets CD62p and TSP in intracerebral hematoma fluid were higher than those in venous blood.There were significant positive correlations between the expression levels of CD62p and TSP from the surface of platelets in hematoma and the edema size perihematoma(CD62p:r=0.4781,TSP:r=0.5183,all P

Study on the relationship of platelets activation and inflammatory reaction in hematoma at acute phase of intracerebral hemorrhage / 临床神经病学杂志

Objective To investigate the leukocyte infiltration inside the hematoma and the correlation between this and the expression of platelet P-selectin (CD62p) and platelet thrombin-sensitive protein (TSP) of patients with cerebral hemorrhage. Methods In 33 patients with cerebral hemorrhage treated with minimally invasive surgery, the expressions of platelet CD62p and TSP were detected by flow cytometry (FCM) and leukocyte counts were measured in intracerebral hematoma fluid and venous blood. The correlation analysis was performed between the two variables.Results The expressions of platelet CD62p and TSP in hematoma fluid were higher in patients with acute cerebral hemorrhage (20.25?1.82, 37.04?3.63) than those in venous blood (7.72?2.19, 12.32?2.81)(all P