ABSTRACT
The purpose of this study was to understand the long term changes in clinical picture and the markers of hepatitis B virus (HBV) in patients with hepatitis B, and to provide an objective evalution and a beneficial countermeasure. Altogether 182 patients with hepatitis B diagonsed by histopathological assay had been followed up for 1 to 15 years.The serum samples were collected and tested for liver fonction, markers of HBV and HBV DNA level once every year. The results showed that of the 182 patients, 14 died, 15 developed liver cirrhosis, and 6 developed liver cancer. HBsAg and HBeAg seroconversion happened in 13 6% and 87 9% of the patients, respectively. The percentage of positive HBsAg in patients older than 60 decreased at a great rate. Our conclusion in the markers of HBV in patients with chronic hepatitis B could dissapear automatically or, on the contrary could hardly dissapear, resulting persistentce of liver damage. The patients with liver cirrhosis could live for a iong time if they took good care of their health properly.