Research progress of population pharmacokinetics applying to individualized med-ication / 药学实践杂志

Combining the classic pharmacokinetic principles and statistical methods ,population pharmacokinetics (PPK ) can predict individual pharmacokinetic parameters accurately with sparse data in patients ,which may be used for monitoring drug concentration in patients and realizing individual dose regimen .In this article ,we review the recent application of PPK in drugs with narrow therapeutic windows or great individual differences ,combining medication ,medication in special populations and so on ,providing useful information for further investigation of PPK and its application in clinical medication .