ABSTRACT
Coronavirus disease(COVID-19) is a novel explosive infectious disease that has caused a serious public health crisis all over the world. The immunosuppression after novel coronavirus infection and insidiously progressive disease evolution lead to a series of unique characteristics of severe COVID-19 that are different from other severe infection.The key to reduce fatality rate of this disease is fully recognizing the evolution characteristics of severe COVID-19 patients, early warning and identification of patients who will progress to severe, and giving appropriate personalized nutrition support and organ function support scheme to the severe patients.So that we can buy the time for the patients to repair the immune function and remove viruses. This paper discussesed the special pathophysiological characteristics and clinical management of severe COVID-19 patients, so as to provide some references for the management of such patients in the future.