ABSTRACT
@#Basic fibroblast growth factor (bFGF) exhibits superior biological functions by improving periodontal inflammation, promoting the migration and proliferation of periodontal-related stem cells, promoting the formation of blood vessels and periodontal ligament-like tissue, and regulating the formation of bone/cementum. It plays an important role in tooth development, repair and regeneration. bFGF can be combined with seed cells and scaffold materials for periodontal tissue regeneration, which has been verified in a number of experimental studies. However, the application of bFGF alone as a drug in clinical treatment requires further research.
ABSTRACT
@#Increasing numbers of adult patients are seeking orthodontic treatment, which increases the need for orthodontists to treat malocclusion in periodontally compromised teeth affected by periodontitis. It is essential to control active inflammation prior to initiating an orthodontic protocol to avoid further breakdown of alveolar bone caused by periodontitis. However, whether the condition of periodontal ligaments can completely recover to a normal condition after controlling inflammation and tolerate orthodontic tooth movement remains controversial. The present review elaborates, from clinical trials (macroscopic) to biological tests (microscopic), the characteristics of periodontal tissue and periodontal ligament cells with a history of periodontitis that are submitted to orthodontic force loading. The following conclusions are made: 1. Orthodontic treatment in periodontally compromised patients is unusual because of changes in periodontal condition. 2. The combination of orthodontic force loading and uncontrolled periodontal inflammation aggravates pathological bone resorption; therefore, it is crucial to perform periodontal therapy prior to orthodontic treatment. 3. The periodontal ligament can withstand proper mechanical force loading after periodontal treatment. 4. Orthodontic treatment, as an adjunctive therapy, can improve periodontally compromised tissue and pathological tooth movement.
ABSTRACT
Objeetive To observe the efficacy and safety of 5 g · L-1 Lotemax suspended eye drops in inflammation control after phacoemulsification combined with intraocular lens implantation.Methods Together 60 patients with senile cataract (grade III or more severe) underwent cataract surgery were selected and randomly divided into two groups,including Lotemax group,in which patients were given 5 g · L-1 Lotemax suspended eye drops and Tobramycin eye drops,and Tobradex group,in which patient were alone given Tobradex eye drops.Corneal edema,anterior chamber flare,corneal volume,anterior chamber volume and corneal incision thickness were observed at 1 day,7 days and 30 days after operation,while intraocular pressure was observed at 7 days and 30 days before and after operation.Then the efficacy of Lotemax in control of postoperative inflammation was evaluated by Pentacam's anterior segment analysis system.Results There was no significant difference in corneal edema,anterior chamber flare,corneal volume,anterior chamber volume and corneal incision thickness between the two groups at postoperative 1 day and 30 days (all P ＞ 0.05),but Tobradex group had weak anterior chamber flare and lower corneal volume than Lotemax group (P =0.029,0.019),while the difference in corneal edema,anterior chamber volume and corneal incision thickness was not statistically significant between two groups at postoperative 7 days (P =0.119,0.138,0.101).Moreover,there was no significant difference in intraocular pressure at 7 days and 30 days before and after surgery between the two groups (all P ＞ 0.05).Conclusion Lotemax suspended eye drops can effectively control the inflammation followed by cataract phacoemulsification combined with intraocular lens implantation.
ABSTRACT
Objeetive To observe the efficacy and safety of 5 g · L-1 Lotemax suspended eye drops in inflammation control after phacoemulsification combined with intraocular lens implantation.Methods Together 60 patients with senile cataract (grade III or more severe) underwent cataract surgery were selected and randomly divided into two groups,including Lotemax group,in which patients were given 5 g · L-1 Lotemax suspended eye drops and Tobramycin eye drops,and Tobradex group,in which patient were alone given Tobradex eye drops.Corneal edema,anterior chamber flare,corneal volume,anterior chamber volume and corneal incision thickness were observed at 1 day,7 days and 30 days after operation,while intraocular pressure was observed at 7 days and 30 days before and after operation.Then the efficacy of Lotemax in control of postoperative inflammation was evaluated by Pentacam's anterior segment analysis system.Results There was no significant difference in corneal edema,anterior chamber flare,corneal volume,anterior chamber volume and corneal incision thickness between the two groups at postoperative 1 day and 30 days (all P ＞ 0.05),but Tobradex group had weak anterior chamber flare and lower corneal volume than Lotemax group (P =0.029,0.019),while the difference in corneal edema,anterior chamber volume and corneal incision thickness was not statistically significant between two groups at postoperative 7 days (P =0.119,0.138,0.101).Moreover,there was no significant difference in intraocular pressure at 7 days and 30 days before and after surgery between the two groups (all P ＞ 0.05).Conclusion Lotemax suspended eye drops can effectively control the inflammation followed by cataract phacoemulsification combined with intraocular lens implantation.