ABSTRACT
Objective To investigate the changing patterns of serum IL-6, IL-10, IL-23 and osteopontin in patients with smear-negative pulmonary tuberculosis before and after treatment and their clinical implication.Methods A total of 43 patients with smear-negative pulmonary tuberculosis and 40 healthy controls were included in this study. Enzyme-linked immunosorbent assay (ELISA) was conducted to measure the levels of serum IL-6, IL-10, IL-23 and osteopontin in healthy individuals and patients before and after anti-tuberculosis treatment for 2, 4 and 6 months.Results The levels of serum IL-6, IL-10, IL-23 and osteopontin in patients with smear-negative pulmonary tuberculosis were signiifcantly higher than those in control group (P0.05). The levels of serum IL-6 and IL-23 gradually decreased after treatment, and restored to normal at six months. There was no signiifcant difference compared with those in control group (P>0.05). Conclusions Serum IL-6, IL-10, IL-23 and osteopontin levels in patients with smear-negative pulmonary tuberculosis can be used as sensitive indicators for assessment of tuberculosis disease activity and therapeutic effect of anti-tuberculosis drugs.
ABSTRACT
The fetal inlfammatory response syndrome (FIRS) is a subclinical condition characterized by systemic acti-vation of the fetal innate immune system with a large number of pro-inlfammatory cytokines released. FIRS is the fetal coun-terpart of the systemic inlfammatory response syndrome (SIRS) described in adults. Intrauterine infection is the most common reason of FIRS. FIRS has been implicated as a cause of preterm labor, preterm white matter injury, bronchopulmonary dyspla-sia (BPD) and necrotizing enterocolitis (NEC).