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As one of the flexible means of drug supervision, the “compassionate medicine use system” has become a new way to meet the drug accessibility of patients at present. The “compassionate medicine use system” in Britain, that is, Early Access to Medicine Scheme, intervenes in the drug development process of the applicant enterprises at an early stage through the cooperation of different government departments, which not only ensures patients obtain innovative drugs in time, but also accelerates the drug listing and payment and reimbursement process. At present, China has only made principled provisions on the “compassionate medicine use system”, but has not issued specific implementation rules. It is suggested that the access conditions of “compassionate medicine use”, the responsibilities and obligations of different subjects, the payment mechanism of expenses and how to promote the cooperation of relevant departments should be clearly defined as soon as possible in combination with the system experience of Britain, so as to form a standardized and operable “compassionate medicine use system” suitable for China’s national conditions.
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Objective To explore the effect observation of four-dimension innovative service concept applied to hospital logistics management.Methods Retrospective analysis of the survey results of 500 hospitalized patients,42 hospital staff,187 public facilities/medical instruments and equipment before and after the application of the four-dimension innovative service con-cept(March-June 2022)and after the application(March-June 2023).The satisfaction of patients and employees on logistics work and the difference of repair rate and complaint rate before and after application were compared.Results After the applica-tion,the satisfaction of patients and staff on logistics work were significantly higher than before the application(P<0.05),and the repair rate of logistics after the application(10.70%)was significantly lower than before the application(18.18%)(P<0.05),and the complaint rate of logistics(5.00%)was also significantly lower than before the application(8.20%)(P<0.05).Conclusion The application of four-dimensional innovative service concept in hospital logistics management can effec-tively enhance the satisfaction of patients and staff on logistics work,and reduce the logistics repair rate and complaint rate,and it can be popularized in various hospitals.
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Innovation is an important way to promote economic development and social progress. Recent years have seen rapid development of biological sciences. In response to social demands and the needs for developing an innovative country, fostering innovative talents in the field of biosciences has become a significant initiative supported by national policies and the needs from talent market. Taking the innovative talent training mode implemented by Zhejiang Normal University in the field of biological sciences as an example, this paper comprehensively introduces several key aspects of the mode. This includes establishing a mentorship system as the foundation, carrying out curriculum reform through project competitions and practical platforms, and promoting synergy among industry, academia, and research in talent training. This training mode has achieved positive results in practice, promoting the training of outstanding innovative talents in biological science majors, and may facilitate the reform of talent training in similar majors.
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Humans , Biological Science Disciplines , Industry , Policy , UniversitiesABSTRACT
In the context of "New Era" and "New Medicine", the teaching team of laboratory diagnostics proposed a new teaching method of PDCA (Plan, Do, Check, Action) cycle to innovate the instructional design and implementation of laboratory diagnosis on the base of traditional teaching model. Through optimizing the curriculum system, integrating superior resources, taking full advantage of information technology, mobilizing the virtual simulation laboratory, implementing moral education and multiple comprehensive evaluation results, the self-learning enthusiasm, innovation and development ability of students were improved significantly, accompanied with high humanistic care spirit. Moreover, the enthusiasm of participating in scientific research activities and professional competitions was enhanced obviously. Therefore, we believe that the PDCA cycle, with notable successes, deserves high promotion value and wide application.
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Payment by diagnosis related groups(DRG)is an important research direction in China's current medical insurance payment reform.However,it limits the clinical development and utilization of innovative medicines to a certain extent.Additional payments for innovative medicines have been thoroughly studied in many countries.This paper conducted an analysis and summary of the global experience regarding additional payment for innovative medicines under the DRG payment system.U-sing the United States,France,and Germany as case studies,this paper also examined the current state of medical insurance pay-ment for innovative medicines in China and the influence of DRG payment on the development of such medicine.In addition,it has put forward explicit policy recommendations,including the establishment of inclusion criteria,the selection of appropriate payment modes,the implementation of dynamic adjustment mechanisms,the enhancement of payment methods,etc.This paper aims to provide references to comprehensively promote DRG payment reform while further establishing and enhancing medical in-surance payment mechanisms related to innovative medicines in the context of China's national conditions.
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Background: During the coronavirus disease 2019 (COVID-19) pandemic, there was a reduction in access to prevention of mother-to-child transmission (PMTCT) of human Immunodeficiency virus (HIV) services globally, yet this programme is critical for reducing paediatric HIV incidence. To minimise the impact of COVID-19 and prevent disruptions to the PMTCT service provision, innovative strategies had to be developed and implemented. Aim: The study aimed to describe the approaches that were developed and utilised during the COVID-19 pandemic in enhancing PMTCT services in Tshwane primary healthcare facilities. Settings: Three primary healthcare facilities that were providing PMTCT services during the COVID-19 pandemic located in the Tshwane district, Gauteng province, South Africa. Methods: The study is part of a larger study that focused on the experiences of healthcare workers who were rendering PMTCT services during the COVID-19 pandemic. An interpretative phenomenological analysis (IPA) design was employed to gain insight into the experiences of 16 purposively sampled healthcare workers who were providing PMTCT services during the pandemic in Tshwane district facilities. In-depth individual audio-recorded interviews were conducted with study participants, following a semi-structured interview guide. Data analysis was performed using an IPA framework. Results: Three superordinate themes emerged: strategies utilised for providing care, community-based initiatives, and support systems to enhance the PMTCT service access. Conclusion: Strengthening community-based initiatives and support systems is important for the enhancement of the PMTCT programme during and beyond the pandemic. Contribution: Community-based initiatives are critical in continuity of PMTCT services, reducing HIV incidence, under-five child morbidity and mortality particularly during emergency situations.
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HIV Infections , COVID-19ABSTRACT
tendo como foco a criação de um recurso pedagógico digital inovador destinado a aprimorar o ensino de fisiologia humana na Escola Básica. Método:Trata-se de um relato de experiência, de caráter descritivo, acerca das vivências de professores da Universidade Estadual de Feira de Santana e de uma Escola Pública do Estado da Bahia, entre outubro de 2022 a outubro de 2023. As atividades foram organizadas em duas etapas interconectadas: 1) Realização de um Curso de formação de Educação à Distância (EaD) durante a Semana Nacional de Ciência e Tecnologia (SNCT). 2) Elaboração de um material didático inovador envolvendo as tecnologias digitais educacionais, como produto final do Curso EaD realizado na SNCT. Resultados:Elaboração do jogo de tabuleiro, intitulado jogo de trilha gamificada denominada "Trilha Corpo Humano: Conhecer para Cuidar". Conclusão:A proposta desenvolvida no presente trabalho vislumbrou a inovação da prática pedagógica, por meio do desenvolvimento de novas tecnologias educacionais, contribuindo para a melhoria do ensino na Escola.
Objective: To report the experience of integrating University and Primary School Teachers, focusing on the creation of an innovative digital pedagogical resource aimed at improving the teaching of human physiology in Primary Schools. Method:This is an experience report, of a descriptive nature, about the experiences of teachers at the State University of Feira de Santana and a Public School in the State of Bahia, between October 2022 and October 2023. The activities were organized in two interconnected stages: 1) Carrying out a Distance Education (EaD) training course during National Science and Technology Week (SNCT). 2) Creation of innovative teaching material involving digital educational technologies, as the final product of the Distance Learning Courseheld at SNCT. Results:Preparation of the board game, entitled gamified trail game called "Human Body Trail: Knowing to Care". Conclusion: The proposal developed in this work envisioned the innovation of pedagogical practice, through the development of new educational technologies, contributing to the improvement of teaching at School.
Objetivo: Reportar la experiencia de integración de Profesores Universitarios y de Educación Primaria, centrándose en la creación de un recurso pedagógico digital innovador orientado a mejorar la enseñanza de la fisiología humana en la Escuela Primaria. Método: Se trata de un relato de experiencia, de carácter descriptivo, sobre las vivencias de docentes de la Universidad Estatal de Feira de Santana y de una Escuela Pública del Estado de Bahía, entre octubre de 2022 y octubre de 2023. Las actividades se organizaron en dos espacios interconectados. etapas: 1) Realización de un curso de capacitación en Educación a Distancia (EaD) durante la Semana Nacional de Ciencia y Tecnología (SNCT). 2) Desarrollo de material didáctico innovador que involucre tecnologías educativas digitales, como producto final del Curso a Distancia realizado en el SNCT. Resultados:Elaboración del juego de mesa, titulado Juego de Sendero gamificado denominado "Human Body Trail: Saber Cuidar". Conclusión:La propuesta desarrollada en este trabajo vislumbró la innovación de la práctica pedagógica, a través del desarrollo de nuevas tecnologías educativas, contribuyendo a la mejora de la enseñanza en la Escuela.
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Universities , Education, Primary and Secondary , Technology , Human BodyABSTRACT
Background: Students studying dentistry typically have minimal opportunities to develop their teaching abilities. There is no literature in dentistry education that describes the merger of ‘Early Clinical Exposure’ (ECE) and ‘Near Peer Learning’ (NPL) Module with regard to first-year BDS students and interns. Author created a novel module for ECE and NPL to evaluate its impact in knowledge. Materials and methods: 2016 to 2022 six batches students and interns participated in this module including 535 First BDS students and 60 interns. This study was conducted in two phases: Initial Preparation by Faculty to teach theory and demonstrations to First BDS students and Training Sessions for interns and in second phase the actual implementation of ECE-NPL Module. The first year BDS students were first time introduced in clinics and Alginate impression clinical procedure was demonstrated on patients by interns. The Global Rating Scale was used to validate and rate the pre-test and post-test checklist. Paired t-tests were used for the pre- and post-test analyses to evaluate the module's outcomes. Results: Paired t-tests analysis of Pre and post-tests to evaluate outcome of the module shows that outcome factors are increased by the demonstration in clinics. The chi-square goodness of fit test for impact of ECE on students was ?2 (3)=315.654, p value<0.05 and for Intern’s perception about NPL was ?2 (2)=37.900, p value<0.05 and First Year Student’s perception about NPL was ?2 (4)=586.393.Conclusion: This study shed light on the clinical training approach used in a dental undergraduate program and emphasized the advantages of ECE and NPL in the study population. It works well as a supplement to conventional teaching techniques. The positive feedback from the students was received and scored high rating.
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As per the new competency-based medical education curriculum, teaching and learning methods have been shifted from teacher-centric to student-centric to provide students with opportunities for diverse learning experiences through interactive learning. So, the department introduced innovative teaching in the classroom environment to make students understand the concept of community diagnosis in detail so that it will be beneficial for them while executing an actual visit to their family. A village was simulated in the classroom; students were randomly identified as medical students who were going to interact with villagers for the purpose of community diagnosis, whose roles were played by the remaining students. After that, the student explained the process with input from faculty. Feedback from students was taken through a Google form about the activity. There was a self-driven response from students with their active participation. They felt that it was a very interactive class and it prepared them for the field visit. Such simulation activities can be used as a teaching and learning method for relevant competencies with limited resources.
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The primary objective of this study is to analyse the annual and seasonal rainfall trends in the Bapatla district of Andhra Pradesh over the long term. The seasonal rainfall data for Bapatla district was collected from the NASA Power website and covering the period from January 1982 to December 2021. To gain insights into the patterns present in the rainfall data for Bapatla district, a combination of parametric methods, including linear regression, and non-parametric tests such as the Mann-Kendall test, Sen’s slope test, Modified-Mann Kendall test, Innovative trend analysis were employed in this approach. The randomness of the rainfall data under investigation was assessed using the Wallis and Moore test. To detect the single change point of the rainfall pattern Pettitt test was employed. The results of linear regression trend method exhibited both increasing and declining trends in rainfall pattern. Notably, the months of April, May and June months exhibited a statistically significant increasing trend other months exhibited no significant trend in Mann-Kendall test, modified Mann-Kendall test, Sen’s slope tests. The monsoon season exhibited a statistically significant trend and pre-monsoon, post-monsoon periods and anuual rainfall exhibited non-significant trends in Mann-Kendall and Sen’s slope tests. Moreover, the pre monsoon and monsoon seasons exhibited significant trend in rainfall pattern of Bapatla district by modified Mann-Kendal test. This study serves to raise awareness among agricultural stakeholders, particularly farmers, regarding the fluctuations in monthly and seasonal rainfall patterns and enables them to more effectively allocate resources and prepare for anticipated water shortages during non-monsoon months.
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Carbon emissions pose a massive risk to our planet's health. According to the Paris Climate Agreement, nations pledged to limit global warming to 1.5°C to mitigate climate change's impacts. This target will not be achieved without immediate and deep emissions reductions across all sectors. Unfortunately, the Russian-Ukrainian conflict and the new natural gas discoveries in some countries have also slowed down the pace of decarbonization. Aside from that, a faint light at the end of the tunnel could be seen from the new Intergovernmental Panel on Climate Change (IPCC) report, which pointed to increasing actions on climate change. Fortunately, achieving future zero carbon emission is still possible via the implementation of holistic frameworks that promote existing and emerging green technologies and helps the community to transform. This policy paper proposes a framework that integrates technology use and mobilizes the transformation of communities' mindsets to cope and adapt to climate change. The proposed framework will then be implemented in the country hosting the 27th Conference of the Parties of the UNFCCC (COP 27), Egypt, and it is recommended to be used by scholars and policymakers for future assessment of the country's climate change performance. Finally, the paper provides a set of recommendations to governments, policymakers, and communities to accelerate the movements toward a net zero-carbon future.
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Introducción: Se realizó una revisión que permite comprender mejor por qué es necesaria una visión más integradora de la neuropsicología del adolescente para la aplicación de métodos de intervención desde las neurociencias que permitan enfrentar la conducta de riesgo sexual y reproductivo. Objetivo: Actualizar sobre los aspectos particulares de la neurofisiología de la adolescencia, que los puede hacer proclives a desarrollar una conducta de riesgo en cuanto a la función reproductiva. Material y Método: Revisión de la literatura sobre el tema, publicada en el período 2017-2022. Se utilizaron las bases de datos: PubMed/MEDLINE, Lilacs, Scielo, Cochrane, y The National Library of Medicine. Resultaron incluidas 26 fuentes bibliográficas para las citas, por reunir los requisitos de mayor especificidad, originalidad y aporte al tema. Desarrollo: El desarrollo del adolescente genera transformaciones radicales en su personalidad, que están relacionadas con cambios importantes en las estructuras cerebrales, que aún no están completamente desarrolladas. Las técnicas de resonancia magnética muestran que los principales cambios en el cerebro del adolescente afectan la corteza prefrontal, por lo que son más proclives a la falta de autorregulación y a una excesiva excitabilidad. La plasticidad de esta etapa explicaría cómo las conductas erróneas pueden imprimirse negativamente y dar lugar a las actitudes que llevan al fracaso, particularmente aquellas relacionadas con la sexualidad y la función reproductiva. Conclusiones: Se aportaron reflexiones críticas que permiten confirmar el hecho de que existen insuficiencias en los métodos para la modificación de la conducta de riesgo sexual y la función reproductiva en adolescentes. Se aportan nuevos enfoques de enfrentamiento.
Introduction: A review was carried out to allow a better understanding of why a more inclusive vision of adolescent neuropsychology is necessary for the application of intervention methods in the field of neuroscience that allow confronting sexual and reproductive risk behavior. Objective: to update on the particular aspects of the neurophysiology of adolescence, which can make them prone to develop risk behavior in terms of reproductive function. Material and Methods: Review of the literature on the subject, published in the period 2017-2022. Databases such as PubMed/MEDLINE, Lilacs, SciELO, Cochrane, and The National Library of Medicine were used. Twenty-five bibliographic sources were included for citations, as they met the requirements for greater specificity, originality, and contribution to the topic. Development: The development of the adolescent generates radical transformations in his personality, which are related to important changes in brain structures that are not yet fully developed. Magnetic resonance techniques show that the main changes in the adolescent brain affect the prefrontal cortex, which is why they are more prone to a lack of self-regulation and excessive excitability. The plasticity of this stage would explain how erroneous behaviors can be negatively imprinted, giving rise to attitudes that lead to failure, particularly those related to sexuality and reproductive function. Conclusions: Critical reflections are provided, which confirm the fact that there are weaknesses in the methods for the modification of sexual behavior and reproductive risk in adolescents. New confrontation methods are provided.
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Humans , Adolescent , Sexual Behavior/ethics , Sexuality/physiologyABSTRACT
Based on the current situation of approval and publicity of class II innovative medical devices in various provinces and cities, especially after analyzing the problems found in the review of class II innovative medical devices in Shanghai and the factors affecting the listing process of innovative medical devices, this study puts forward some thoughts on supervision for reference in establishing and perfecting systems and regulations, changing the review and approval thinking, extending services to the development of innovative medical devices and the formulation of clinical trial schemes.
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Device Approval , China , Equipment and SuppliesABSTRACT
OBJECTIVE To analyze the implementation experience of France’s additional list system for innovative medical products, and to provide reference for China to support medical institutions to use innovative medical products. METHODS Taking France as a case study, using policy analysis method, this paper systematically studied the practice of establishing additional list system to compensate for innovative medical products in France under diagnosis-related group (DRG) payment, including the establishment background, selection procedure and implementation effect. The suggestions were provided on the medical insurance payment methods for innovative medical products in China. RESULTS & CONCLUSIONS The additional list system established a compensation and payment system for innovative medical products with significant clinical efficacy but high treatment cost, covering four stages: application, evaluation, payment and adjustment, which effectively reduced the drug burden on medical institutions, promoted the use of innovative pharmaceutical products by medical institutions, and stimulated the innovation drive of the pharmaceutical industry, but at the same time brought payment pressure to the medical insurance fund. With the rapid spread of our DRG/diagnosis-intervention packet payment reform of China, some regions have also explored the establishment of a compensation and payment mechanism for innovative medical products, but there are still imperfections. We can refer to the implementation experience of the French additional list system and establish an effective compensation and payment system for innovative medical products starting from the establishment of selection criteria, the selection of compensation mode and the implementation of dynamic adjustment.
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Objective To study the relationship among the sense of organizational fairness, innovative self-efficacy (ISE) and innovative behavior in nurses. Methods A total of 392 nurses from a grade A tertiary hospital were selected as the research subjects using convenience sampling method. The Organizational Fairness Scale, Innovation Self-efficacy Scale, and Innovation Behavior Scale were used to evaluate the sense of organizational fairness, ISE, and innovation behavior, respectively. The mediate equation model was constructed, and Bootstrap analysis was applied for validation. Results The scores for organizational fairness, ISE, and innovative behavior among the nurses were (67.8±15.2), (23.9±3.5), and (30.5±6.7) points, respectively. Organizational fairness score was positively correlated with both innovative behavior and ISE scores [correlation coefficients (r) were 0.38 and 0.36, respectively, both P<0.01]. ISE score was positively correlated with innovative behavior total score (r=0.51, P<0.01). The results of the mediation analysis indicated that the total effect of organizational fairness on innovation behavior was 0.34 (P<0.01),with a direct effect of 0.17 (P<0.01). ISE plays a mediating role between organizational fairness and innovation behavior among nurses(P<0.01) with standardized mediation effect of 0.17, accounting for 50.0% of the total effect. Conclusion Organizational fairness can influence the ability of innovative behavior directly or through the mediating role of ISE.
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Novel drug discovery from the active ingredients of traditional Chinese medicine is the most distinctive feature and advantageous field of China, which has provided an unprecedented opportunity. However, there are still problems such as unclear functional substance basis, action targets and mechanism, which greatly hinder the clinical transformation of active ingredients in traditional Chinese medicine. Based on the analysis of the current status and progress of innovative drug research and development in China, this paper aimed to explore the prospect and difficulties of the development of natural active ingredients from traditional Chinese medicine, and to explore the efficient discovery of trace active ingredients in traditional Chinese medicine, and obtain drug candidates with novel chemical structure, unique target/mechanism and independent intellectual property rights, in order to provide a new strategy and a new model for the development of natural medicine with Chinese characteristics.
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Medicine, Chinese Traditional , Drugs, Chinese Herbal/chemistry , Research , Drug Discovery , ChinaABSTRACT
Objective:To understand the current situation of physicians′ innovative behavior and its influencing factors in Beijing municipal hospitals, for reference in improving their innovation ability and encouraging high-quality development of public hospitals.Methods:A stratified sampling was conducted with 22 practicing (assistant) physicians in Beijing municipal hospitals as subjects. From October to November 2022, a questionnaire survey was conducted to understand the innovative behavior, innovative self-efficacy and innovative atmosphere of such practicing (assistant) physicians. SPSS 25.0 was used for descriptive analysis of the data, while t-test, variance analysis and linear regression were used for univariate analysis. Furthermore, multiple linear regression was adopted to explore the influencing factors of innovative behavior of such practicing(assistant) physicians. Results:A total of 2 178 questionnaires were distributed in this study, and 1 906 valid ones were recovered, with effective recovery of 87.51%. Scores of innovative behavior, innovative self-efficacy and innovative atmosphere of 1 906 practicing (assistant) physicians scored (4.00±0.70) points, (3.85±0.74) points and (3.98±0.66) points respectively. The results of univariate analysis showed scores of statistical significance regarding the innovative behavior of practicing (assistant) physicians with different marital status, educational background, professional title, position, department type, innovative self-efficacy level and innovative atmosphere level. Multiple linear regression results showed that position, innovation self-efficacy score, innovation atmosphere score and subordinates′ incentive mechanism, as well as teamwork and resource security had statistical significance on innovation behavior score.Conclusions:The practicing (assistant) physicians in Beijing municipal hospitals are highly enthusiastic for innovation, but their innovative behavior is expected to be upgraded. In this regard, public hospitals should improve their innovation incentive mechanism, strengthen resource assurance, encourage cooperation and exchange, and create a desirable atmosphere for innovation. Furthermore, greater supply of continuing education resources is expected, supporting these physicians in their further study, advanced education, and promotion of professional titles.
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Research in stomatology (dental medicine) continues to expand globally and is oriented towards solving clinical issues, focusing on clarifying the clinical relevance and potential mechanisms of oral-systemic connections via clinical epidemiology, oral microecological characterization, and the establishment of animal models. Interdisciplinary integration of materials science and tissue engineering with stomatology is expected to lead to the creation of innovative materials and technologies to better resolve the most prevalent and challenging clinical issues such as peri-implantitis, soft and hard tissue defects, and dentin hypersensitivity. With the rapid development of artificial intelligence (AI), 5th generation mobile communication technology (5G), and big data applications, "intelligent stomatology" is emerging to build models for better clinical diagnosis and management, accelerate the reform of education, and support the growth and advancement of scientific research. Here, we summarized the current research status, and listed the future prospects and limitations of these three aspects, aiming to provide a basis for more accurate etiological exploration, novel treatment methods, and abundant big data analysis in stomatology to promote the translation of research achievements into practical applications for both clinicians and the public.
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Animals , Oral Medicine , Artificial IntelligenceABSTRACT
The development of new agricultural science is a new idea and a new measure that aims to deepen the reform of higher education in agriculture and forestry for the development of new agriculture, new countryside, new farmers and new ecosystem. It is therefore essential for the current undergraduate experimental teaching reform to timely introduce new technologies and new methods used in the development of agriculture and forestry industry into the experimental course teaching, and promote the integration of professional education with innovation and entrepreneurship education, according to the requirements of the new agricultural science. In view of this, the exploration and practice of molecular biology experiment course was carried out from the perspective of experimental projects, teaching modes and evaluation methods, according to the teaching requirements and characteristics of molecular biology experiment and teachers' scientific research achievements. The results showed that this reform greatly improved the students' comprehensive quality and innovation ability and may facilitate the innovation experiment teaching of other courses.
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Humans , Ecosystem , Students , Curriculum , Molecular BiologyABSTRACT
Undergraduates in colleges and universities have great academic potential. In order to cultivate undergraduate innovative scientific research talents, the key is to improve the cultivation mode of undergraduates and stimulate students' academic potential. Taking the evidence-based medicine research group of Guangdong Medical University as an example, this paper systematically analyzes the specific measures and relevant practical experiences of the research team in the cultivation of undergraduates. The research team creatively uses the methods of "student guidance system", "PBL" mode and real-time feedback mechanism, and a complete talent training system has formed to explore a group of excellent undergraduate talents. Through innovative scientific research training, these undergraduates have made many achievements in academic research. This paper hopes these strategies and experiences can provide some reference for the cultivation of undergraduates in colleges and universities all over the country.