ABSTRACT
Objective To investigate the clinical effect of knee arthroscopy combined with celecoxib in the treatment of elderly patients with knee osteoarthritis.Methods According to the random table method,62 elderly patients with knee osteoarthritis admitted to the Third People's Hospital of Zhuji from October 2016 to October 2018 were divided into control group (31 cases) and observation group (31 cases) according to the digital table.The control group was treated with knee arthroscopic debridement ,while the observation group was orally given celecoxib on the basis of the control group.Both two groups were treated for 12 weeks.The curative effect of the two groups was compared,and the changes of WOMAC scale score,knee joint active flexion and extension and inflammatory factors before and after treatment were compared.Results The excellent and good rate of the observation group (83.88％) was higher than that of the control group (51.62％) (χ2 =7.381,P<0.05).After treatment,the scores of stiffness[(3.56 ±0.38)points], difficulty in daily activities[(27.38 ±7.19)points]and pain[(7.94 ±2.45)points] in the observation group were lower than those in the control group [(5.81 ±0.76)points,(38.98 ±5.42)points and (11.36 ±1.87)points](t=10.182,14.743,6.178,all P<0.05).After treatment,the knee joint active flexion and extension in the observation group[(91.24 ±7.86)°] was higher than that in the control group [(83.42 ±7.39)°](t=4.036,P<0.05).After treatment,the serum levels of IL -1beta[(16.58 ±4.25) ng/L],TNF-α[(183.25 ±24.15) ng/L] and IL -6 [(9.98 ±2.43) ng/L] in the observation group were lower than those in the control group [(26.31 ±5.47)ng/L, (219.82 ±29.96)ng/L and (14.52 ±4.35)ng/L](t =7.821,5.291,5.073,all P <0.05).Conclusion Knee arthroscopy combined with celecoxib has good clinical effect on elderly patients with knee osteoarthritis .It can improve knee function,alleviate inflammation and improve active knee flexion and extension .
ABSTRACT
Objective To detect the damage of hippocampal neurons and the changes in inflammatory cytokines in rats after cerebral ischemia-reperfusion(I/R)and compare the expressions of IL-1β,IL-6 and TNFαin hippocampal DG,CA1 and CA3 subregions.Methods The focal cerebral I/R model was induced by an intraluminal filament embolism.The SD rats were randomly divided into the sham-operated group(SHAM group)and the middle cerebral artery occlusion-reperfusion group(MCAO group).HE staining was employed to detect the damage to hippocampal DG, CA1 and CA3 subregions.The expression levels of IL-1β, IL-6 and TNFα were detected by immunofluorescence assay.Results Compared with SHAM group,hippocampal DG,CA1 and CA3 subregion neurons in MCAO group were severely damaged, with occurred inflammatory cell infiltration,and a large amount of neurons apoptosis, and the expressions of IL-1β, IL-6 and TNFαin each subregion increased significantly.At the same time, in MCAO group, the expression of inflammatory cytokines in CA1 subregion was more significant than that in DG and CA 3 subregions(P<0.05).Conclusion Cerebral I/R could cause neuronal damage, inflammatory cell infiltration, and neuronal apoptosis in the DG, CA1 and CA3 subregions of the hippocampus and increase the release of inflammatory cytokines.In MCAO group, the expression of inflammatory cytokines in CA1 subregion of hippocampus is significantly higher than that in DG and CA 3 subregions, suggesting that CA1 region is more sensitive to I/R injury.