Research progress in association between interleukin 28B gene polymorphism and hepatitis B / 临床肝胆病杂志

Hepatitis B virus (HBV) infection seriously threatens human health. Viral, environmental, and host factors can influence the progression, outcome, and prognosis of HBV infection. Accumulating evidence has shown that the host interleukin 28B gene polymorphism is, to a certain degree, associated with host immunity, anti-HBV efficacy of interferon, and HBV infection outcome. However, at present a consistent conclusion has not been reached yet. IL28B may influence the efficacy of interferon therapy and virus spontaneous clearance in patients with chronic hepatitis B (CHB) by affecting the host′s immune status. Examining the immune status for CHB patients before the experimental study may help researchers to draw a more consistent conclusion.