ABSTRACT
Objective To explore the effects of the therapeutic effects of interventional heated chemotherapy( IHC) for moderate and advanced huge primary hepatocellular carcinoma and compare with transcatheter arterial chemoembolization( TACE) . Methods The 68 pa-tients with moderate and advanced huge primary hepatocellular carcinoma accepted the treatment of IHC were considered as the observation group,and 32 patients managed TACE were regarded as the control group. The therapeutic effects,living quality,secondary surgery rates,The reduced level of serum AFP,survival rate,and toxic side effects of 2 groups were contrasted. Results The effective rate of observation group was obviously higher than that of control group (79. 4% vs 56. 3%,P <0. 05),and secondary surgery rates was increased(70. 6% vs 43. 8%,P<0. 01). The ratio of increased Karnofsky score was more than 20 in observation group,which was obviously higher than that of control group(35. 3% vs 12. 5%,P<0. 01). T The reduced level of serum AFP was more than 50% in observation group,which was higher than that of control group (52. 9% vs 25. 0%,P<0. 01). The survival rate of 12,18,24 months after treatment in control group was in-creased than that in control group individually (P<0. 01). Conclusion IHC is effective for huge primary hepatocellular carcinoma and in-creases the secondary surgery rates,which is one of the safe and effective methods for huge primary hepatocellular carcinoma.
ABSTRACT
Objective: To investigate the changes in the immune function of T-lymphocyte subsets and natural killer (NK) cells after intraarterial perfusion of thermo-chemotherapy in patients with primary hepatic carcinoma and the clinical significance. Methods: The changes in the immune function of T-lymphocyte subsets and NK cells were examined by immunofluorescence staining in 84 cases of primary hepatic carcinoma before and after intraarterial perfusion of thermo-chemotherapy and compared with 78 cases who received conventional interventional chemotherapy (control group). Results: (1) There was no significant decrease in the proportion of CD3 + and CD4 + T- lymphocytes and the ratio of CD4+/CD8+ (P > 0.05), but the number of NK cells significantly increased (P 0.05). At two weeks after treatment, the levels of CD3 + and CD4 + T- lymphocytes, the ratio of C04 +/CD8 +, and the number of NK cells in thermo-chemotherapy group were obviously higher than those in the control group (P < 0.05). Conclusion: Intraarterial perfusion of thermo-chemotherapy rapidly increases the number of T-lymphocytes and NK cells in the peripheral blood and effectively antagonizes the decrease in the immune function induced by conventional interventional chemotherapy, which plays a positive role in controlling tumor metastasis.