ABSTRACT
Objective To study the clinical efficacy of the combination of sephedex and docetaxel used in transcatheter arterial chemoembolization (TACE) for clinical treatment of primary liver cancer.Methods 120 patients with primary liver cancer in our hospital were divided into the experimental group and the control group randomly and equally, the 60 cases in experimental group were treated with sephedex suspensoid (Sephedex, G-50, 300-500 μm) and docetaxel-iodized oil, while other 60 cases in control group were treated with docetaxel-iodized oil suspension liquid.Results The success rate of surgical intubation in the two groups was 100%.After an average follow-up of 12 months, the postoperative tumor diameter of the experimental group was reduced by (4.4±1.4) cm, while that of the control group was (1.8±1.0) cm;The overall response rate was 70% in the experimental group in contrast to 30% in the control group;the alpha fetal protein (AFP) value was decreased by (33.2±15.2) μg/L in the experimental group and (10.4±9.8) μg/L in the control group.Conclusion The combination of sephedex, docetaxel suspensoid and iodized oil shows great potential in TACE treatment of primary liver cancer, from which the treatment effect can be improved significantly.
ABSTRACT
Objective To study the ZT glue postpone iodinated oil metabolism in liver. Methods We had intubated into right portal veins for 5 rabbits, injected 131 iodine iodinated oil and ZT glue, successively recorded ? counts of liver region by ? calibration equipment, created local 131 iodine iodinated oil metabolism equation, calculated effective half drained times, and finally observed the liver and lung in pathology. Another 5 rabbits had been merely injected with 131 iodine iodinated oil as the control group. Results Experimental 131 iodine iodinated oil slow group was higher in proportion than the control group, with delaying of effective half drained times. 131 iodine iodinated oil had been retained more proportion within right liver causing damage to liver tissue. Conclusions ZT glue can postpone iodinated oil metabolism in liver.