1.
Chinese Pharmacological Bulletin
;
(12)1987.
Article
in Chinese
| WPRIM
| ID: wpr-551035
ABSTRACT
The action of dl - tetrahydropal-matine(dl-THP) was studied in two preparations in vitro : the isolated rat gastric mucosa and parietal cells, dl-THP was found to inhibit significantly basal acid formation by the gastric mucosa in a dose - response fashion. The effect was reversible, acid secretion returning to control levels 1. 5~2h after the preparation underwent a double wash, dl - THP also produced asignificant and dose - dependent inhibition of histamine - induced secretion in the gastric mucosa and parietal cells, shifted the histamine dose -response cuver to the right and suppressed the maximum acid production, with pD_2~1 values of 4. 72 and 4. 70, respectively.