ABSTRACT
A relação maléfica entre hipertensão arterial sistêmica (HAS) e dislipidemia torna-se explícita a partir da análise da progressão dessas comorbidades simultaneamente, agravando diretamente o risco cardiovascular. Se observa o aumento de espécies reativas do oxigênio gerando estresse oxidativo, a diminuição da biodisponibilidade de óxido nítrico promovendo disfunção endotelial, maior concentração de moléculas LDL oxidadas o que resulta na progressão de eventos ateroscleróticos. Somado a isto, se percebe que o tratamento em conjunto das duas doenças é mais eficaz quando comparado ao tratamento de cada uma delas isoladamente, demonstrando o efeito sinérgico do tratamento em conjunto. Concluindo então, que as comorbidades estão intimamente relacionadas e agravam o estado geral do paciente
The harmful relations systemic arterial hypertension (SAH) and dyslipidemia be comes explicit from the analysis of the progression of these comorbidities simultaneously, directly aggravating cardiovascular risk. There is an increase in reactive oxygen species generating oxidative stress, a decrease in the nitric oxide bioavailability promoting endothelial dysfunction, a higher concentration of oxidized LDL molecules which results in the progression of atherosclerotic events. In addition, it is clear that the joint treatment of the two diseases is more effective when compared to the treatment of each separately, demonstrating the synergistic effect of the joint treatment. In conclusion, then, that comorbidities are closely related and aggravate the patient's general condition
Subject(s)
Humans , Dyslipidemias/complications , Heart Disease Risk Factors , Hypertension/diagnosisABSTRACT
@#AIM:To study the therapeutic effect of visual occlusion combined with levodopa and benserazide hydrochloride tables on children with amblyopia. <p>METHODS: Totally 90 cases(140 eyes)of children diagnosed with amblyopia in our hospital were selected from January 2016 to January 2017. They were randomly divided into the monotherapy group and the combined treatment group, and 35 healthy children(70 eyes)were selected as the normal group for comparison. Patients in the monotherapy group were treated with visual cover, while patients in the combined treatment group were treated with oral administration of levodopa and benserazide tablets on the basis of visual cover. Tears were extracted from both groups of children before and after treatment, and the protein levels of CREB and PKA in tears of 140 eyes and 70 eyes of children in the normal group were detected by enzyme-linked immunosorbent assay. The index levels of the two groups and the normal group were compared, as well as the therapeutic efficiency of different age groups and the total therapeutic efficiency of different methods. <p>RESULTS: After treatment, the levels of IL-1β, IL-6 and IL-9 in the combined treatment group were significantly lower than those in the single treatment group after treatment(<i>P</i><0.05).After treatment, the levels of CREB and PKA in the combined treatment group were significantly lower than those in the single treatment group(<i>P</i><0.05).The total effective rate of children at the age of 3-6 in the combined treatment group and the single treatment group was significantly higher than those at the age of 7-9 and 10-12 in each group(<i>P</i><0.05). The total therapeutic efficiency of the combined treatment group was significantly higher than that of the single treatment group, and the difference was statistically significant(<i>P</i><0.05). <p>CONCLUSION: Combined with the traditional masking method, levodopa and benserazide hydrochloride tables can improve the treatment of children's amblyopia. The earlier the treatment time, the better and the higher efficiency is.
ABSTRACT
Objective To study the clinical curative effect of small needle knife combined with manipulation on adhesive capsulitis.Methods Totally 120 adhesive capsulitis patients treated from March 2014 to November 2015 were enrolled in the study,and divided into a treatment group and a control group randomly and equally.The patients in the treatment group were treated with small needle knife combined with manipulation,and the ones in the control group took anti-inflammatory analgesics orally.The changes of shoulder joint pain and function scores as well as the clinical effects were observed and compared in the two groups.Results The treatment group behaved significantly better than the control group in the indexes of shoulder pain,pressing pain,nyctalgia,internal and external rotation,adduction,abduction and etc (P＜0.05).The total effective rate was 93.3％ in the treatment group,which was obviously higher than that (68.3％) in the control group (P＜0.05).Conclusion The curative effect of combined manipulation and small needle knife gains advantages over oral antiinflammatory analgesics when used to treat adhesive capsulitis patients,and thus is worthy promoting practically.
ABSTRACT
Objective To investigate the feasibility and significance of joint microwave ablation for simultaneous treatment of two or more benign neoplasms originating from different organs which are conventionally managed in different disciplinary offices. Methods We treated a middle-aged female patient suffered with a large thyroid adenoma and a huge liver cavernous hemangioma with microwave ablation under local anesthesia and general anesthesia consecutively in one treatment session. The safety of operation and dynamic therapeutic effect were assessed. Results The thermal ablation procedures were both successful and eventful. The total operation time was about 90 minutes. The patient was discharged on the third day after ablation. During the follow-up, ultrasonography revealed a significant shrinkage of thyroid adenoma and liver hemangioma and recovery of the perinodular thyroid or liver tissue. The laboratory tests showed functional abnormalities of neither the thyroid, nor the liver and kidney. Conclusion: Joint microwave ablation for simultaneously treating large thyroid adenoma and huge liver cavernous hemangioma was verified safe, efficacious and medical resources sparing. This innovative therapeutic concept is worth of further investigation and promotion.