ABSTRACT
In some molecular targeted therapies, skin disorders including acne-like rashes or maculopapular rashes frequently appear, which are often clinically problematic. In Kampo medicine, it has been reported that the combination of jumihaidokuto and orengedokuto (hereinafter called JHT + OGT) is effective for acne. In this study, we report the experiences of JHT + OGT for the treatment of rashes caused by molecular targeted therapies. We extracted patients from June 2013 to June 2017 who took molecular targeted therapies and the treatment with JHT + OGT for skin rashes. The primary endpoint was severity of rashes before and after treatment by JHT + OGT (judged by CTCAE v4.0). In 22 patients (14 males and 8 females), the rashes after treatment with JHT + OGT significantly improved compared with those before treatment (from the median grade of 2 to 1 [p = 0.011]), with 14 cases of improvement, 6 cases of no change, and 2 cases of deterioration. It was suggested that JHT + OGT for skin rashes caused by molecular targeted therapies could be one of the treatment options.
ABSTRACT
OBJECTIVE@#To study the effect of Jumihaidokuto (Shi-Wei-Bai-Du-Tang, ) in the management of chronic spontaneous urticaria.@*METHODS@#A randomized two-arm, parallel group study was conducted to compare the effect of Jumihaidokuto (6 g daily) with a control for 8 weeks. Concomitant therapy (e.g., antihistamines) was continued. Twenty-one subjects with severe chronic urticaria were enrolled in this study. The primary treatment outcome was the severity score proposed by the Japanese Dermatological Association. Secondary outcomes were quality of life (Skindex-16), itch intensity (Visual Analogue Scale), and patients' subjective disability due to wheal or itch. After the subjects were randomly assigned to groups by block randomization, 10 received Jumihaidokuto, and 11 did not. All subjects had already taken antihistamines.@*RESULTS@#Improvement was significant when comparing the severity score of the Jumihaidokuto group with that of the control group (P<0.01). Skindex-16 values for both groups gradually decreased in the same fashion.@*CONCLUSION@#Concomitant use of Jumihaidokuto with antihistamine was more effective than antihistamine alone in the management of chronic idiopathic urticaria. (Trial Registration No. UMIN000007251).
ABSTRACT
Wells' syndrome (eosinophilic cellulitis), whose etiology is idiopathic, is clinically characterized by solitary or multiple cellulitis-like eruptions which occur on the extremities and trunk. Corticosteroids are usually used for palliative treatment, but relapses are often observed. We observed an 8 year-old patient with Wells' syndrome successfully treated with Kampo medicines. In 2001, skin eruptions appeared on his extremities. In 2002, a histopathologic examination determined his disease to be Wells' syndrome, and corticosteroids were subsequently used for treatment. In January 2007, his skin eruptions worsened, and he first visited our outpatient clinic in May. After oral administration with keigairengyoto, his skin eruptions were slightly improved, but afterwards, they again worsened. In June, jumihaidokuto was administered instead of the former prescription, and the skin conditions had begun to improve. Because dry skin appeared in November, keigairengyoto was again added. With these treatments, his skin eruptions stably improved. In previous reports, Kampo medicines had not been used for the treatment of Wells' syndrome. This case, however, suggests that Kampo medicines are a candidate for the treatment of Wells' syndrome.
ABSTRACT
We successfully treated 5 patients with seborrheic dermatitis using Kampo medicine. Three of these patients presented with facial the lesions which had persisted for 1 to 2 years despite their having received treatment with steroid ointments or ketokonazol lotions. We treated these patients with jumihaidokuto and they recovered significantly within a few months. The two remaining patients presented with scalp lesions, which had persisted for10and 25 years respectively. We treated them with a combined formulation of keigairengyoto, makyoyokukanto and yokukansankachimpihange, and they improved remarkably after 2 and 8 months respectively.
Subject(s)
Medicine, Kampo , Dermatitis, SeborrheicABSTRACT
We report a case of a 40-year-old male with mycosis fungoides who was successfully treated with traditional herbal (Kampo) medicine in addition to Western medicine-including electron beam therapy and local injections of IFN-γ. In December 1991, he noticed erythema on his upper extremities, and the eruptions gradually worsened. In July 1997, various-sized skin tumors appeared on his trunk. He was diagnosed as being at the tumor stage of mycosis fungoides on the basis of a histological examination.<br>In September1997, he was referred to our department and was treated with Jumi-haidoku-to, Takuri-shodoku-in, Naitaku-san, Kyuki-kyogai-to, etc., for his skin lesions. When he felt thirst and heat from the irradiation, he was given Byakko-ka-ninjin-to. He also received Ohgi-kenchu-to for diarrhea and general malaise. He is currently receiving IFN-γ and immunotherapy at the department of dermatology, and his condition is good. Careful follow-up will be necessary. It is thought that the traditional herbal medicines are useful for the treatment of mycosis fungoides.
ABSTRACT
Twenty-seven cases with verruca vulgaris were examined in which the treatment consisted of oral administration of biscoclaurin alkaloids and Kampo medicine (Jumi-haidoku-to) with Siun-ko ointment. Seven of these cases were cured within one month-12 cases were cured within three months; and 8 cases required more than 3 months for a cure to be effected. However, there were no regressions or ineffective cases. Histopathological features of 5 cases examined after two or four weeks usage of Siun-ko ointment showed swelling of keratinocytes with formation of lacunae or fissures. This combination is thought to be an effective and useful treatment.
ABSTRACT
Patients with acne vulgaris which could not be sufficiently controlled with antibiotics (tetracycline), or who had been receiving treatment for a prolonged period were selected for treatment with Kampo medicine. Patients in whom joint use of Kampo resulted in a decrease in blemishes, patients who were able to reduce the amount of antibiotics required or stop antibiotics altogether and patients who improved with Kampo alone were grouped according to the Kampo formula being taken. The formulas Seijobofu-to, Jumihaidoku-to and Keishibuuryo-gan proved to be effective. The patients in these groups were found to have certain characteristics in common. In particular, almost all of the cases with adult acne (25 years of age or older) had the symptoms of cold hands and feet, stiff shoulders, menorrhalgia, worsening of the condition before the menstrual period and other symptoms associated with Stagnated Blood. Formulas known as ‘agents for expelling Stagnated Blood’ (Kuoketsuzai), particularly Keishibukuryo-gan, were found to be effective.