Prognostic indicators among laboratory data on arrival to assess the severity of mamushi bites / Journal of Rural Medicine

Objective: This study aimed to retrospectively determine which laboratory data on arrival for patients with mamushi bites was useful to predict the severity of mamushi bites.Materials and Methods: The subjects were divided into the following two groups: the mild group included subjects with mamushi bites Grades I and II, while the severe group included subjects with mamushi bites Grades III, IV, and V. The subjects’ variables were compared between the two groups.Results: There were no significant differences between the two groups regarding the levels of hematocrit, total protein, alanine aminotransferase, aspartate aminotransferase, creatinine phosphokinase, blood urea nitrogen, creatinine, and international normalized ratio of prothrombin time on arrival. Moreover, white blood cell count and platelet count on arrival in the mild group were significantly lower than those in the severe group. Furthermore, activated partial thromboplastin time on arrival was significantly higher in the mild group than in the severe group. Multivariate analysis using white blood cell count and platelet count and level of activated partial thromboplastin time revealed the following significant prognostic indicators of severity of mamushi bites: white blood cell count (Log Worth, 2.1; p<0.01) and platelet count (Log Worth, 1.6; p<0.05).Conclusion: White blood cell count and platelet count on arrival of patients with mamushi bites are considered significant prognostic indicators in determining the severity of mamushi bites.

Ethical issues in the study of clinical laboratory data based on omics techniques / 中华医学科研管理杂志

With dramatic decline of genome sequencing cost,high-throughput sequencing technologies have been applied in clinical laboratory field,and play an increasingly important role in clinical diagnosis and treatment in complex diseases.Based on omics techniques,clinical laboratory data recording patient's diagnosis information has become the important independent medical research resources of the major health industry.Because these data include the patient's identity information,there are a series of ethical issues to be solved,such as protection of patients' informed consent right,patient privacy protection,information security protection,when carrying out the medical health big data research.Based on these problems,it proposed clinical laboratory data should be standard extraction,establishment of clinical laboratory data base for teaching,training,in order to improve the utilization of medical resources.Moreover,it is best to implement the written informed consent during the process of sample collection,informing the patient the data collected in diagnosis and treatment process may be used in related research in future.

Investigation on Supplements Use in Medical Check-Up Examinees from the Point of Laboratory Data and Subjective Health Perception / 日本補完代替医療学会誌

<b>Objective:</b> Although there are numerous epidemiological studies on supplement use, only a small number of studies focused on the issue of the subjective health perception and the clinical laboratory data. The aim of this study was to determine the relation between supplement use and the subjective health perception and the clinical laboratory data.<br> <b>Method:</b> The participants were asked to complete a self-administered questionnaire on supplement use, and subjective health perception (“overweight”, “easy fatigability”, “lower tolerance”, and “anxiety about bone and joints”) during the previous one month. The clinical laboratory data (blood pressure, fasting blood glucose, LDL-C), demographic information, smoking status and drug use were collected from the record at the medical checkup center.<br> <b>Results:</b> 608 men and 500 women were enrolled. A total of 30.3% of participants were found to use supplements. Logistic regression analysis revealed that supplement users were more likely to be women, older than 40 years, with lower or higher BMI, and with the normal laboratory data. However, the four items of subjective health perception and the three laboratory data were not individually associated with the supplement use.<br> <b>Conclusion:</b> Supplement use was associated with middle aged women with low or high BMI and normal clinical laboratory data.<br>

Research Related to Chronic Kidney Disease in BMI >25 Overweight Children

PURPOSE: Chronic kidney disease (CKD) and obesity are the worldwide public health problem. Obesity is an already well-established risk factor for CKD. The objective of this study is to evaluate the relationship between high BMI and increased risk for nephropathy by clinical data. METHODS: Study group were 26 patients who had BMI> or =25 kg/m2 and control group were 49 patients with BMI<25 kg/m2. Both groups received renal biopsy in Kyung Hee Medical Center between 2003. Jan.-2007. Dec. BMI was calculated from measured weight and height when they were admitted to the hospital. We collected laboratory data such as CBC and blood chemistry. RESULTS: Our hypothesis was that overweight and obesity are associated with incidence and progression of CKD. From kidney biopsy, we found IgAN 17, MesPGN 5, HSPN 2, Intestitial nephritis 1, IgMN 1 (total 26) in the study group whereas IgAN 22, MesPGN 17, HSPN 3, MGN 3, benign hematuria 2, MPGN 1, Intestitial nephritis 1, (total 49) were found in the control group. There was no significant difference between the two groups. Overweight patients demonstrated significantly higher platelet, TG, ALT, and uric acid level compared to control group. CONCLUSION: We identified a significant relationship between overweight and development of CKD. These results suggest that overweight children have an increased risk for CKD than those who are not obese. So, we should pay attention to children with overweight who have CKD and earlier weight management is crucial to prevent aggravation of CKD.

Scorpion envenomation symptoms in pregnant women

Scorpion envenomation is common in many countries; however, its effects on pregnancy are still unclear. In the present paper, we described the effects of scorpion envenomation on pregnant patients. A retrospective study was carried out considering the clinical and laboratory exams of patients admitted to the emergency room of Habib Bourguiba Hospital, Sfax, Tunisia, from 1990 to 2004. Variability of these clinical and laboratory profiles according to maternal age, gestational age and number of previous parities was also discussed. Among 167 scorpion-envenomed women, age ranged from 17 to 42 years, 7.18 percent were pregnant. These presented symptoms similar to those of non-pregnant women envenomed by scorpions. Two pregnant patients developed intense pelvic pain and one manifested vaginal bleeding. Although the studied parameters showed non-significant differences, we could conclude that scorpion envenomation may lead to abnormal uterine contraction probably causing preterm delivery. Maternal disturbances induced by scorpion envenomation may influence the fetus development. The effects were more severe in the second trimester of pregnancy.(AU)

The affect of body position on 32 biochemical indexes / 中华检验医学杂志

Objective To investigate the affect of body positions on biochemical indexes. Methods By autogenous contrast and cross matched survey, 107 volunteers divided into 3 season patches of winter, spring and summer, blood samples were drawn from the same part in both standing and lying positions。From19 persons, blood samples were collected respectively after standing and sitting for 15 min, lying for 15 min and 30 min and then sitting for another 15 min。 The blood samples were analyzed for 32 biochemical indexes on analyzer。Results 25 biochemical indexes in sitting position were significantly different from those in lying position (P0。05)。Conclusions Changing body position can result in obvious physiological variation of 28 biochemical indexes, particularly of those related to protein. Such result may lead to abnormality in some marginal values. It suggests body position should not be neglected in analyzing laboratory data.

Low dose lorazepam in psychoneurotic outpatients

In a double blind study, 32 patients were randomly divided into three treatment groups, namely, placebo, 1 tablet b.i.d., lorazepam 0.5 mg. b.i.d., and lorazepam 1.0 mg. b.i.dCoefficient of regression analysis during the first three weeks of treatment showed significantly faster improvement in both lorazepam groups compared with placebo. With the fourth week included, statistically significant difference was attained only with lorazepam 1.0 mg. b.i.d. compared with placebo. Side effects were seen in 10 patients, including 3 placebo patients; these either promptly responded to reduction in dosage or were transitory without change in dosageLaboratory data before treatment were not significantly different from post-treatment values. Laboratory data before and after treatment showed no evidence of drug toxicityThe efficacy of lorazepam even at low doses of 0.5 mg. b.i.d. and 1.0 mg. b.i.d. attests to its potency as an anti-anxiety agent. (Summary)

The factors related with office worker's health perception

BACKGROUND: Recently, the concept of health is being extended to physical, mental and social aspects, which leads people to pursue health positively behavior. But the evaluation of health condition shows a tendency to be biased to functional side. It means the absence of well being sensation that anyone feels like he has poor health. In this case, even if he is in physically good health, he is not rated as healthy. We analyzed the relationship between one's health state and the factors related with health perception including health behavior, mind and social environment. METHODS: For a month of May 1996, we surveyed those who visited for Periodic medical check-up at one general hospital in Seoul. The questionnaire consisted of the total of 25 items ; diet behavior, weight control, coffee, coke, tea, drug use of, smoking, drinking, exercise, leisure, safety belts use, jay walking, sleep, stress, personality, anxiety, depression, occupational satisfaction, relationships with family and friends. Five point scale is used as the answer of each question item with high point as good living behavior. Among 406 who had sincerely answered the questionnaire, we divided them into healthy and unhealthy group and compared with the point of each question item and with the laboratory data(obesity, blood pressure, hemoglobin, fasting blood sugar, cholesterol and ALT). RESULTS: Among 406, the number of those who perceived themselves to be healthy was 175(43.1%, healthy group) and the one of those who did not was 231(56.9%, unhealthy group), The difference between both groups was not significant in distribution of sex, age, academic career, income and religion. In laboratory data and living behavior they showed same results, also. But the points of unhealthy group were significantly lower than those of healthy group in coffee, coke, tee, drugs usage, exercise, leisure, stress, personality, anxiety, depression, occupational satisfaction and relationship with family and friends. So was the total point of all items of unhealthy group in comparison with that of health group. In the case of male, the points of unhealthy group were significantly lower in smoking, safety belt use, fay walking, sleeping as well as the above items. On the contrary, in the case of female, both groups were not significantly different all item except exercise and leisure. CONCLUSIONS: Health perception is influenced by psychosocial factors and living behavior more than by physical health. Therefore family physician must be concerned about patient's living behavior, mental and social problems and must make an effort to change their perception of health as well as physical improvement.

Differences in Clinical Laboratory Data between the Elderly and the Young Adults / 영남의대학술지

Due to the lowering of biological functions resulted from old age, the elderly is known to have many different clinical laboratory data compared with the young adults. But, in korea, such study is lacking. This research is to find the differences between the elderly and the young adults, and also to know the sexual differences, by comparing the outcomes of the clinical laboratory data. Along with that, it is to help clinical usage of the data in the future. The age of the elderly was between 60 and 83(average age 63.8), and that of the young controls was between 20 and 35. In both sexes, MCV, MCH, ESR, CRP,AST, ALT, gamma GTP, ALP, BUN, total cholesterol were significantly higher in the elderly than in the controls. And lymphocyte count(%), total bilirubin, direct bilirubin, total protein, albumin, T3 were significantly lower in the elderly than in the controls(P<0.05). Hemoglobin, Hct, platelet count, T4 were significantly lower only in the male elderly, and eosinophil count(%), creatinine were significantly higher only in the female elderly(P<0.05). HDLcholesterol was significantly higher only in the male elderly(P<0.01). There were no significant difference between two groups regarding WBCcount, segment neutrophil count(%), monocyte count(%), TSH. Many clinical laboratory data are different between the elderly and the young adults, and some clinical laboratory data also have sexual differences.

The Correlation Between Abdominal Palpation Signs of Kampo Medicine and Laboratory Data / 日本東洋医学雑誌

There have been few studies on the relationship between the body mass index (BMI), complete blood cell count, blood chemistry, fatty liver evidence and Kampo abdominal palpation signs. This study was designed to clarify the above points. It involved 484 subjects who had undergone full physical examinations. The results of this study, can be summarized as follows:<br>1. Abdominal tension (traditionally referred to as “fukuryoku”) was related to BMI (males and females), TG, TCh/HDL, GPT, RBC, Hb and evidence of fatty liver (males) and corresponded negatively with HDL (males).<br>2. Tonus of the rectus abdominis muscle (“fukuhikokyu”) was negatively related to BMI (males).<br>3. The sound of gurgling liquid in the stomach (“shinsuion”) was negatively related to BMI (males and females).<br>4. Palpitations of the abdominal aorta in the upper abdomen (“shinkaki”) was related toHDL (males) and negatively related to BMI (males and females).<br>5. Palpitation of the abdominal aorta below the navel (“saikaki”) was negatively related to BMI (males).