ABSTRACT
Objective To compare the curative effect of transcatheter arterial chemoembolization (TACE) combined with microwave ablation (MWA) with that of simple TACE in treating large liver cancers.Methods A computer-based search assisted by manual searching for TACE+MWA vs simple TACE clinical control trials for large liver cancers was conducted.The patient survival,tumor response and complications were enrolled in the scope of analysis.Results A total of 16 papers met the inclusion criteria,which included 1199 patients in total.Meta-analysis indicated that one-,2-and 3-year survival rates of TACE+MWA group were better than those of simple TACE group,and the differences between the two groups were statistically significant (P＜0.01).The complete response (CR) rate and partial response (PR) rate of TACE+MWA group were higher than those of simple TACE group,and the differences between the two groups were statistically significant (P＜0.01).The stable disease (SD) rate and progressive disease (PD) rate of TACE+MWA group were lower than those of simple TACE group,and the differences between the two groups were statistically significant (P＜0.01).Conclusion For the treatment of large liver cancers,TACE +MWA is superior to simple TACE.(J Intervent Radiol,2017,26:225-231)
ABSTRACT
Objective To investigate the feasibility of CT-guided radiofrequency ablation for conservative treatment of patients with large hepatocellular carcinoma (LHCC) before radical resection. Methods Patients with secondary large liver cancer were selected as group A(radiofrequency ablation group,n = 27)and group B (surgical treatment group ,n = 33). Liver function ,immunological function ,postoperative complications ,hospi-talization time ,and 3-year relapse-free survival (RFS) were observed between two groups after treatment. Results After treatment,patients′liver function(ALT,AST,ALB,TB),and immune function(CD3+T,CD4+T, CD8+T,CD4+/CD8+,NK,B,Treg)in group A were better than those in group B(P<0.05). There were shorter hospitalization time and lower complication rate in group A when compared with those in group B(P < 0.05)but there was no significant difference regarding to 3-year RFS(P > 0.05). Conclusions Although radiofrequency ablation cannot effectively improve patients′ RFS,but with faster postoperative recovery,less complications,and effective protection for liver function and immune function of patients ,it is a feasible conservative treatment for patients′with LHCC before radical resection.
ABSTRACT
Objective To investigate the feasibility of CT-guided radiofrequency ablation for conservative treatment of patients with large hepatocellular carcinoma (LHCC) before radical resection. Methods Patients with secondary large liver cancer were selected as group A(radiofrequency ablation group,n = 27)and group B (surgical treatment group ,n = 33). Liver function ,immunological function ,postoperative complications ,hospi-talization time ,and 3-year relapse-free survival (RFS) were observed between two groups after treatment. Results After treatment,patients′liver function(ALT,AST,ALB,TB),and immune function(CD3+T,CD4+T, CD8+T,CD4+/CD8+,NK,B,Treg)in group A were better than those in group B(P<0.05). There were shorter hospitalization time and lower complication rate in group A when compared with those in group B(P < 0.05)but there was no significant difference regarding to 3-year RFS(P > 0.05). Conclusions Although radiofrequency ablation cannot effectively improve patients′ RFS,but with faster postoperative recovery,less complications,and effective protection for liver function and immune function of patients ,it is a feasible conservative treatment for patients′with LHCC before radical resection.