ABSTRACT
Objective To investigate the efficacy of intravitreal injection of monoclonal antibody in the treatment of patients with exudative age-related macular degeneration (AMD).Methods Together 33 patients (33 eyes) with exudative AMD from February 2010 to May 2015 selected in this study were treated with intravitreal injection of ranibizumab,followed by examination of the best corrected visual acuity before and after surgery by international standard logarithmic visual acuity chart.The differences in ophthalmic artery (OA),central retinal artery (CRA) and ciliary artery hemodynamic parameters before and after operation were compared,and fundus fluorescein angiography (FFA) was used to measure and calculate the changes in choroidal neovascularization (CNV) fluorescein leakage area before and after operation.Results The best corrected visual acuity was significantly improved 1 week after operation when compared with preoperative data [(0.29 ± 0.18) vs.(0.16 ± 0.15)],with significant difference (P =0.002).And 7 days after operation,the area of CNV fluorescein leakage was less than that of postoperative data [(8.48 ± 6.13)mm2 vs.(11.39 ± 6.12)mm2],and the difference was statistically significant (P =0.029).However,there was no difference in OA,CRA,the peak systolic velocity (PSV),end diastolic blood flow velocity (EDV)and resistance index (RI),pulsatility index (PI) in the treatment eyes between before operation and 1,4 weeks after operation (all P ＞ 0.05).Conelusion Intravitreal injection of ranibizumab in the treatment of exudative AMD is safe and effective and can effectively improve the visual acuity and alleviate CNV leakage,without adveme effects on patients' hemodynamics.
ABSTRACT
Introdução e objetivo: A desadaptação marginal em restaurações do tipo inlay é um problema crítico para dentistas, em razão das consequências danosas que sua intensidade pode causar ao dente, ao periodonto e á longevidade da restauração. O objetivo deste trabalho foi avaliar, pelo cálculo da área combinado á maior distância entre a borda cervical da restauração e do preparo, o desajuste marginal cervical de dois sistemas de compósito e um de cerâmica prensada. Material e métodos: Tendo como base um modelo mestre metálico com preparo para inlay MOD, 15 troquéis de gesso tipo IV foram obtidos e distribuídos em três grupos (n = 5): Empress, Sinfony e Z350. Após a confecção das restaurações, cada peça foi posicionada no modelo mestre e fotografada nas faces mesial e distal para, por meio de um programa de análise de imagens, fazer a quantificação da desadaptação marginal cervical. Resultados: Quanto á área de desadaptação marginal cervical, houve diferença (P < 0,05) entre todos os grupos, e o Empress apresentou os maiores valores, seguido pelo Sinfony e pelo Z350. Empress e Sinfony demonstraram, respectivamente, áreas de desadaptação 280% e 110% maiores que Z350. No tocante á maior distância entre as bordas da restauraçõo e as margens do preparo, os grupos Empress e Sinfony foram iguais entre si e estatisticamente diferentes (P < 0,05) do Z350, proporcionando, nesta ordem, desadaptação 215% e 120% maior em relação ao grupo Z350. Conclusão: Tanto para o cálculo da área de desadaptação marginal no terço cervical como para o cálculo da maior distância entre a borda cervical da restauração e do preparo, a desadaptação marginal foi menor no grupo Z350, seguido por Sinfony e Empress. Na análise da desadaptação marginal cervical, todos foram considerados aceitáveis para a prática clínica.
Introduction and objective: Marginal leakage of inlays restorations is a key issue for dentists, because of the damaging consequences that its intensity may cause to the tooth, periodontium, and longevity of restoration. The aim of this study was to assess the cervical marginal leakage of two composite systems and a pressed ceramic, through area calculation associated with the longest distance between the restoration and preparation cervical edges. Material and methods: Based on a metal pattern model with MOD inlay preparation, 15 type IV dental stone casts were obtained and randomly distributed into three groups (n = 5) as follows: Empress Group, Sinfony Group, Z350 Group. After restorations had been made, each one was positioned on the pattern model. Following, their middle and distal faces were photographed in order to analyze marginal cervical leakage through a computer software program. Results: Cervical marginal leakage area: there was statistically significant difference among the three groups (P < 0.05). Empress Group presented the highest values, followed by Sinfony and Z350 groups. Empress and Sinfony groups showed, respectively, a leakage area of 280% and 110% higher than Z350 group. Longest distance between restoration and preparation edges: Statistically significant differences were not observed between Empress and Sinfony groups; however, they showed statistically significant (P < 0.05) differences when compared to Z350 group (215% and 120% greater leakage than Z350 group, respectively). Conclusion: Considering the cervical marginal leakage area calculation and the longest distance between restoration and preparation edges, marginal leakage was smaller in Z350 group followed by Sinfony and Empress groups. In the analysis of cervical marginal leakage, all groups were clinically acceptable.