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Wumei Pill is a classic insect repellent prescription, which is used for ascaris lumbricoides and diarrhea. It is considered to be a representative prescription for the treatment of simultaneous occurrence of cold and heat syndromes. Its prescription is mainly composed of sour drugs ( Mume Fructus and bitter wine) and pungent drugs ( Aconiti Lateralis Radix Praeparataaconite, Cinnamomi Ramulus, Sichuan pepper, Angelicae Sinensis Radix, Zingiberis Rhizoma, and Asari Radix et Rhizoma), supplemented by bitter drugs ( Coptidis Rhizoma and Phellodendri Chinensis Cortex) and sweet drugs ( Ginseng Radix et Rhizoma and honey). From the point of view of "Tang-Ye-Jing-Fa Map", the role of liver is to disperse, whose deficiency leads to limb syncope, and excess leads to the full of hypochondrium and abdominal pain. The pungent herbs can tonify the liver-deficiency, the sour herbs can dispel the liver-excess, and sweet herbs can relive them both. The role of spleen is to moderate, whose deficiency leads to fatigue and weakness, and excess leads to the vomiting and diarrhea. The sweet herbs can tonify the spleen-deficiency, the pungent herbs can dispel the spleen-excess, and bitter herbs can relive them both. Therefore, the function of Wumei Pills is located in the liver and spleen, giving consideration to the heart and lung. It is used for the deficiency and excess mixed syndrome of liver and spleen, which is mainly characterized by chest and flank abdominal pain, limb chills, diarrhea, muscle and pulse contracture and the symptoms of the parts along the liver meridian. It is commonly used in the treatment of ascaris, diarrhea, impotence, depression. At the same time, it can also be used for the treatment of diseases about heart and lung, and cough, anxiety and other diseases.
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Liver fibrosis is the leading cause of the morbidity and mortality of liver diseases worldwide and has become one of the key issues in the research on chronic liver diseases among domestic and foreign scholars. An increasing amount of evidence has shown that gut microbiota dysbiosis plays a crucial role in the development and progression of liver fibrosis, and improvement of gut microbiota dysbiosis has become a new target for anti-fibrotic treatment. At present, traditional Chinese medicine has attracted much attention in improving gut microbiota. Studies have shown that "harmonizing liver and spleen" plays an important role in reducing fibrosis degree and delaying the progression of liver fibrosis. Therefore, based on the theory of "harmonizing liver and spleen", the achievements in liver-gut axis and gut microbiota by modern molecular biological techniques can provide a theoretical basis for the treatment of liver fibrosis from "harmonizing liver and spleen" in clinical practice, as well as new directions and ideas for anti-fibrotic treatment with traditional Chinese medicine.
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Objective:To investigate the clinical manifestations of Epstein-Barr virus infection in children and the efficacy of interferon combined with ganciclovir.Methods:A total of 252 children with Epstein-Barr virus infection who received treatment in Liaocheng Maternal and Child Health Hospital from June 2018 to February 2020 were included in this study. They were randomly assigned to undergo treatment either with ganciclovir alone (control group, n = 126) or interferon combined with ganciclovir (experimental group, n = 126). General condition, clinical manifestation, clinical outcomes, and clinical efficacy were compared between the two groups. Results:The 252 children with Epstein-Barr virus infection were divided into four groups according to different age brackets: infancy (3.97%), early childhood (53.57%), preschool (28.97%), school age (13.49%). Children at the early childhood and preschool ages accounted for high proportions. Their clinical manifestations included fever, pharyngeal congestion, cervical lymph node swelling, and pharyngeal pain. Children with hepatosplenomegaly accounted for the highest proportion (44.12%) among those at the school age, and children with binocular edema accounted for the highest proportion (10.37%) among those at the early childhood age. The time to defervesce, eyelid edema, and lymph node regression in the experimental group were (3.55 ± 1.58) hours, (3.82 ± 1.17) hours, and (9.55 ± 1.60) hours respectively, which were significantly shorter than those in the control group [(4.40 ± 1.80) hours, (5.33 ± 1.58) hours, (10.44 ± 1.66) hours, t = 3.64, 2.47, 2.67, P < 0.001, P = 0.024, 0.009]. The total response rate was significantly higher in the experimental group than in the control group [96.03% (107/126) vs. 84.92% (121/126), χ2 = 9.03, P = 0.003]. Conclusion:Epstein-Barr virus infection has different clinical manifestations in children at different ages. Interferon combined with ganciclovir is more effective on Epstein-Barr virus infection than ganciclovir alone.
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Sini Powder was used to treat the symptoms of cold limbs caused by yang-qi depression. Nowadays it is used to sooth the liver and relieve depression as well as regulate the function of liver and spleen. On the basis of syndrome differentiation of TCM combined with modern pharmacological research, Professor FANG Ding-ya uses Sini Powder in a variety of diseases, such as mental disease, lower abdomen disease, and digestive system diseases, and modifies according to different clinical symptoms, with good efficacy.
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To establish mathematical model of Xin’an Wang’s internal medicine for treating epigastric pain through the data mining technique, and provide a more sufficient scientific basis for systematically discussing the rule of traditional Chinese medicines in treating epigastric pain. From the “Wang Zhongqi case” and “Wang Renzhi case”, outpatient medical records of Professor Letao Wang and Professor Jian Wang were used to select 310 cases of medical records in the diagnosis and treatment of epigastric pain according to inclusion criteria. Then we extracted the information of prescription, symptoms and signs, and established “information database of Xin’an Wang’s medical cases of internal medicine for treating epigastric pain”. Using frequency analysis, calculation of high-frequency drugs, and application of IBM Modeler 14.1 by SPSS Apriori algorithm for correlation analysis to extract the core prescription and then establish the mathematical model of Wang’s doctors treating epigastric pain. Wang’s doctors in Xin’an often treat the stomach and spleen with the same treatment of liver and spleen. Wang’s physician treated epigastric pain with both liver and spleen. Wang’s physician assisted the spleen with Tongyang method, or relieved phlegm, dredged liver and Qi to Tongyang, or Xinwen Sanhan to Tongyang, or Jianpi Huashi to Tongyang, or Huoxue Xingqi to Tongyang and Huoxue Sanjie method and Huoxue Huayu method.
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[Objective]Analyzing clinical experience and academic view of Pro. LIAN Jianwei for the treatment of eructation in order to completely learn and master his experience.[Method] Analyzing 4 belching cases of Pro. LIAN, and combining his therapeutic experience and view. [Result] According to the view of Pro. LIAN Jianwei, there are 4 common types in clinic, the type of accumulation in stomach and intestine, the type of spleen and stomach deficiency, the type of liver qi stagnation, the type of liver and spleen disharmony. Promoting digestion and harmonizing stomach to treat the type of food accumulation in stomach;benefiting qi and strengthening spleen to treat the type pf spleen and stomach qi deficiency;smoothing liver and regulating qi to treat type of liver and stomach disharmony; regulating liver and spleen to treat type of liver and spleen disharmony;eliminating damp to treat type of spleen deficiency with damp;activating blood to treat stasis caused by prolonged diseases. Prescriptions of Pro. LIANbased on methods which changed with syndromes. He insisted that treatments base on differentiation;prescriptions base on methods, which make effect well. [Conclusion] It is worthy for our students to learn and imitate clinical experience and academic view of Pro. LIAN Jianwei for the treatment of eructation.
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[Purpose]To summarize and discuss Professor WANG Yue's unique methods of using traditional Chinese medicine to treat HT.[Methed]In the process of diagnosing and treating HT with Prof.WANG in recent years, observing the method of seeking pathogenesis,treating with syndrome differentiation and selecting preferable medicine carefully, summarising Prof.WANG 's viewpoints about HT in the aspects of pathogenesis, treatment and medicine, to conclude Prof.Wang's some experience on HT. [Results]Prof. WANG treats HT from the liver and spleen. On the one hand, Prof. WANG distinguishes the etiology and pathogenesis ,on the other hand he observes the clinical manifestations.In the early stage,he smoothes and refreshes the liver or regulates the spleen with drugs,then nourishes and relaxes the liver or strengthens the spleen medicinally, together with the method of dissipating phlegm and removing blood stasis, tonifying qi and yin,embodying the law of pattern identification and treatment administration to treat the illness,which have made great effects.Modern pharmacology experiments have also confirmed the mechanism of some Chinese medicine in treating HT, providing further supports for the treatment of HT in Chinese medicine.[Conclusion] Prof. WANG treats HT from the liver and spleen and combines the actual and visual conditions together. He not only signifies the feature of traditional Chinese medicine,but also combines with modern pharmacology achievements about the Chinese medicine which has the effect of regulating immune.Prof. Wang follows the principle of integrating Chinese and western medicine,considerating both the illness itself and patients' symptoms to treat HT which is remarkable and worthy of promotion.
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[Objective] To sum up professor SUN Zhiguang's experiences in the treatment of overlap syndrome in gastro-esophageal reflux disease and irritable bowel syndrome.[Method] Expound the academic perspective and clinical experience of Professor SUN Zhiguang in the treatment of this overlap syndrome from the etiology and pathogenesis,therapeutic principle and method,differential diagnosis and treatment,administer medical herbs and prescription,and one case.[Result] Professor SUN considers that exogenous and internal injuries are causes of GERD overlapping IBS,leading to spleen deficientcy and the liver depression.He points out that "incoordination between liver and spleen,disturbance of qi" is the basic pathogenesis of this disease.According to holistic concept,it should be treated by the principle of harmonizing liver and spleen,regulating qi,simultaneously treating stomach and bowl.It is divided into two types,depressing qi is important in the constipation-predominant,and regulating heat and cold is significant in the diarrheapredominant.[Conclusion] Professor SUN specializes in the treatment of the GERD overlapping IBS.This clinical experience has clinical significance.
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Objective] The article explores and analyses the clinical dialectical experience of my postgraduate tutor in the treatment on chronic abdominal pain of children. [Methods]From following professor Sang Gao clinical studies,summarize the experience and thoughts of treating chronic abdominal pain of children,and with a case. [Results]My tutor believes that the pathogenesis of chronic abdominal pain of children caused by weakness of middle energizer, disorder of Qi, which lead to the spleen deficiency and qi stagnation, to cure the disease must treat with liver and spleen together, with activating the spleen and regulating the liver, harmonizing stomach and relieving pain as a rule which can achieve good effect. [Conclusion] Activating the spleen and regulating the liver is an effective treatment, it is worthy of in-depth study and promotion.
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Objective To investigate the relationship and compare the diagnosis in chronic hepatic fibrosis and cirrhosis between liver ADC value and the liver spleen volume ratio changes by MR.Methods The obj ect included 3 1 cases of chronic hepatic fibrosis, cirrhosis and 14 cases of control group.The liver ADC value (b=800 s/mm2 )and the liver spleen volume ratio in different fibrosis stages were measured.Analysis of variances was performed to compare the difference between the two groups.Results The right lobe of liver ADC value and the liver spleen volume ratio in each group was significant (P<0.01).With the increase of fibrosis score,liver ADC was correlated negatively.From normal to mild cirrhosis (S1-S2),the total liver volume increased progressively. From severe hepatic fibrosis to advanced cirrhosis (S3-S4),it decreased slowly and spleen volume increased gradually along as cir-rhosis degree,while the liver spleen volume ratio correspondingly decreased.Area under the curve (AUC)in the group of liver ADC value was 0.789,sensitivity was 0.806,and specificity was 0.857.The group of liver spleen volume ratio AUC was 0.744,sensi-tivity was 0.742,and specificity was 0.714.Conclusion The correlation of the two methods for evaluating the effectiveness of liver fibrosis and cirrhosis are both significant.Whereas,ADC value was better for liver fibrosis,which is the best method for diagnosis of early liver fibrosis.
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Objective To explore application effect of evidence-based nursing in operation of rupture of liver and apleen. Methods 108 patients with rupture of liver and spleen received evidence-based nursing during perioperative period, that is, to determinate nursing problems needed to prove, retrieve and analyze related articles, make the best nursing mode and prevent complications. Results Complications appeared in 15 patients, intra-abdominal hemorrhage in 4 patients, infection in 7 patients and splenic fever in 4 patients. All were corrected in time, and no case showed thrombosis and organ failure. Conclusions EBN can prevent post-operative complications for patients with rapture of liver and spleen and improve nursing quality.
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Children anorexia is not only related with spleen and stomach,but also liver.In clinical treatment,we shall pay attention to regulating mental state;good cure effect can be got by adjusting spleen,stomach and liver together.
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This article presents that the pathology effects between liver and spleen should be divided into hepatic excess transmitting into the spleen,hepatic asthenia implicating injure to spleen and spleen disease influence the liver.Hepatic excess transmitting into the spleen emphasizes the view of excess to transmit while deficiency not to transmit.The excess syndromes of liver in terms of stagnation of liver-qi,hepatic qi,hepatic fire,hepatic yang,hepatic wind,hepatic coldness,dampness-heat of the liver and stagnant qi with drink,phlegm and blood stasis should be divided into three kinds: native-qi stagnant itself,evolving to pathogenic factor and direct attack induced evil occurring inside,they are all excess disease transmitting into the spleen.The hepatic asthenia implicating injure to spleen should distinguish the liver function and liver substance.Deficiencies of liver function are deficiency of liver-qi and deficiency of liver-yang;Deficiencies of liver substance are deficiency of liver-blood and deficiency of liver-yin.Deficiency of liver-qi induces the spleen pertaining to earth can not be abreaction,deficiency of liver-yang mostly implicates injure to splenic yang,deficiency of liver-blood can not be excessive mother element and having stagnation of liver-qi with deficiency of the spleen,deficiency of liver-yin involves the yin of spleen and stomach mostly with asthenic liver-yin causing excessive pyrexia and having sign of stomach-fire.The spleen disease influence the liver mainly presents spleen-earth obstructed and hepatic qi stagnation and spleen disease occurred evil to invade liver.
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0.05). However,Simo Decoction can ameliorate the symptoms,such as epigastric pain,early satiety,etc.,better than Domperidone tablets(P
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Objective To explore relationship between Liver and Spleen of Tradicational Chinse Medicine in T cell activation. Methods The expression of IFN-r and IL-4 of T cells in asthenic spleen qi model and hepatic depression model was detected by RT-PCR. Results IFN-r level of T cells in asthenic spleen qi model significantly decreased, in hepatic depression model significantly increased, in asthenic spleen qi model treated with decoction of four mild drugs rose to normal range, and in hepatic depression model treated with powder of bupleuri dispersing stagnated hepatic qi fell to normal range. The IL-4 level of T cells in asthenic spleen qi model significantly increased, in hepatic depression model significantly decreased, in asthenic spleen qi model treated with decoction of four mild drugs fell to normal range, and in hepatic depression model treated with powder of bupleuri dispersing stagnated hepatic qi rose to normal range. Conclusion Liver and spleen are related to the regulation of THO cells functions.
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BACKGROUND: We analyzed the clinical characteristics of trauma involving the liver and/or the spleen to evaluate the safety of nonoperative management. METHODS: A retrospective study was conducted on 78 cases who were treated with operative (37 cases) and nonoperative (41 cases) management at Wonkwang University Hospital from January 1995 to June 1998. Nonoperative management was done in hemodynamically stable patients. RESULTS: Three cases in the operative group (OG) and 5 cases in the nonoperative group (NOG) were children. Causes of injury were traffic accidents (66.6%), falls (15.4%), penetrating injuries (11.4%), and assaults (6.4%). Associated intraabdominal injuries were renal contusions (42%), pancreatic injuries (18%), mesenteric tearing (12%), diaphragm ruptures (9%). Associated extraabdominal injuries were chest injuries (56.5%), long bone fractures (15.2%), pelvic bone fractures (9.8%), and CNS injuries (8.7%). Mean total blood requirements were 7.0 units in the OG and 1.2 units in the NOG. Complications were 35 cases in the OG (pleural effusion, 6 cases; intraabdominal abscess, 4 cases; pneumonia, 4 cases; biloma, 3 cases) and 15 cases in the NOG (pleural effusion, 5 cases; pneumonia, 5 cases; intraabdominal abscess, 2 cases). Causes of 8 delayed operations were bowel perforations (small bowel 2 cases, and colon, 1 case), bile peritonitis (2 cases), and hemodynamically instability (3 cases). The hospitalization period was 16 days in the OG and 14 days in the NOG. Six patients in the OG died and the causes were multiple organ failures (4 cases), hypovolemic shock (1 case), and ARDS (1 case). No patient died in the delayed operation cases and the NOG, even in major injury cases aquired respiratory distress syndrom. CONCLUSIONS: Nonoperative management of traumatic liver and/or spleen injury is safe and can be tried initially under the conditions of stable hemodynamics, feasible abdominal CT, and feasible immediate operation.