ABSTRACT
Objective To observe the effects of buyang huanwu decoction combined with sarpogrelate hydrochloride in the treatment of elderly diabetes mellitus associated with lower extremity arteriosclerosis obliterans(ASO). Methods 102 patients with diabetic lower limb ASO enrolled in Tongde hospital from December 2014 to December 2016 were divided into the experimental group and the control group according to the treatment way, with 51 cases in each group. The control group was treated with sarpogrelate hydrochloride, the experimental group was treated with buyang huanwu decoction based on the basis of control group, both groups was treated for two months. The clinical curative effect, the dorsalis pedis artery blood flow, ankle brachial index, claudication distance, and adverse reactions occur was compared and observed between two groups. Results The total effective rate of the experimental group was 92.16% higher than 76.47% of the control group (P<0.05). The dorsalis pedis artery blood flow, ankle brachial index, claudication distance of experimental group was higher than the control group (P<0.05). There was no significant difference in adverse reactions between the two groups. Conclusion The effect of buyang huanwu decoction joint sarpogrelate hydrochloride in the treatment elderly diabetes ASO, can relieve body blood, blood fat, blood sugar state, promote patient recovery.
ABSTRACT
Objective To observe the efficacy of Tongmai Acupoint Plaster combined with Alprostadil injection for treatment of lower extremity arteriosclerosis obliterans (ASO). Methods Totally 180 cases of ASO Ⅱ(intermittent claudication period) patients were randomly divided into acupoint sticking group, combination group, Western medicine group, with 60 cases in each group. All groups quit smoking, had diet control, proper exercise, control of blood sugar, stop hypolipidemic and anti-coagulation medicine. The acupoint sticking group was treated with Tongmai Acupoint Plaster, each selected with the efficacy of treatment of lower limbs paralysis acupoint 10-12, alternating dressing; dressing was changed 1 time a day, 40 day as a treatment course. Western medicine group was given Alprostadil injection 10 μg, with 10 mL of normal saline, intravenous infusion, once a day, 15 d as a treatment course, for two courses, with 10 d as interval. Combination group was treated with Tongmai Acupoint Plaster combined with Alprostadil injection, the same as the application method above. The clinical efficacy, the scores of symptoms and signs, the ankle brachial index, blood lipid, the peak value of blood flow in the tibial anterior,posterior tibial, and dorsalis pedis arteries were observed and compared between the 2 groups. Results The total effective rate was 78.33% (47/60) in the acupoint sticking group, 80.00% (48/60) in the Western medicine group, and 93.33%(56/60) in the combination group, with the combination group better than the acupoint sticking group and Western medicine group (P0.05). There was statistical significance in scores of symptoms and signs, ankle brachial index before and after treatment in the three groups (P0.05). There was statistical significance in blood lipids before and after treatment in acupoint sticking group and combination group (P<0.05). There was statistical significance in tibial anterior, posterior tibial, and dorsalis pedis artery peak before and after treatment in the three groups (P<0.05, P<0.01). Conclusion Tongmai Acupoint Plaster has good efficacy in the treatment of ASO, equivalent with the efficacy of Alprostadil injection, which can regulate blood lipids and improve arterial blood flow. Ther combination of them has better efficacy.
ABSTRACT
Objective To observe the effects of buyang huanwu decoction combined with sarpogrelate hydrochloride in the treatment of elderly diabetes mellitus associated with lower extremity arteriosclerosis obliterans(ASO). Methods 102 patients with diabetic lower limb ASO enrolled in Tongde hospital from December 2014 to December 2016 were divided into the experimental group and the control group according to the treatment way, with 51 cases in each group. The control group was treated with sarpogrelate hydrochloride, the experimental group was treated with buyang huanwu decoction based on the basis of control group, both groups was treated for two months. The clinical curative effect, the dorsalis pedis artery blood flow, ankle brachial index, claudication distance, and adverse reactions occur was compared and observed between two groups. Results The total effective rate of the experimental group was 92.16% higher than 76.47% of the control group (P<0.05). The dorsalis pedis artery blood flow, ankle brachial index, claudication distance of experimental group was higher than the control group (P<0.05). There was no significant difference in adverse reactions between the two groups. Conclusion The effect of buyang huanwu decoction joint sarpogrelate hydrochloride in the treatment elderly diabetes ASO, can relieve body blood, blood fat, blood sugar state, promote patient recovery.