ABSTRACT
Corneal lymphangiogenesis plays a crucial role in ocular diseases. Normally, the cornea lacks blood vessels and lymph vessels, which are essential for maintaining transparency and function of cornea. However, certain diseases or injuries will prompt angiogenesis and lymphangiogenesis in cornea, thus disrupting the structure and function of cornea. Although various drugs targeting corneal angiogenesis have been applied in clinical practice, there is still a gap in medications targeting corneal lymphangiogenesis. Therefore, this review will introduce the factors related to corneal lymphangiogenesis, introduce related ocular diseases, and analyze the current treatment status, which will provide more options and possibilities for the treatment of lymphangiogenesis in ocular diseases and provide guidance for future research and drug development.
ABSTRACT
Nodus lymphatic metabasis is an important index for tumor stage and a prognosis, while lymphatic vessel formation plays an important role in pathologic state. Many scholars demonstrated gradually the position of the lymphatic vessel factom and their receptors in the tumor metastases because of the findings of lymph vessel e-ndothelial tissue markers and the establishment of model for lymph vessel formation. Lymphangiogenic factors are gradually becomeing the focus in the studies of tumor lymp-hatic metastasis and cancer treatment of cancer.