ABSTRACT
Objective To explore the effects of marginal division of the striatum (MrD) stroke on associative learning and memory. Methods A total of 21 cases with marginal division of the striatum stroke were used as stroke group. The control group consisted of 21 healthy volunteers matched with the stroke group for sex, age and education. The clinical memory scale edited by Psychological research institute, Chinese academy of sciences was used to evaluate data of learning and memory. Results The score was significantly lower in stroke group compared with that of control group (17.71±5.59 vs. 24.80±5.05, P<0.01). The score was significantly lower in patients with lesions on left than that in patients with lesions on right (11.78 ± 1.48 vs. 22.17 ± 2.17, P<0.01). There was no significant difference in the score between hemorrhagic stroke group (16.50±6.59) and ischemic stroke group (18.46±5.01,P>0.05). Conclusion Marginal division of the striatum stroke can cause the associative learning and memory disorder, which is more serious in patients with lesions on left than that in patients with lesions on right.
ABSTRACT
Objective To explore the effects of marginal division of the striatum (MrD) stroke on associative learning and memory. Methods A total of 21 cases with marginal division of the striatum stroke were used as stroke group. The control group consisted of 21 healthy volunteers matched with the stroke group for sex, age and education. The clinical memory scale edited by Psychological research institute, Chinese academy of sciences was used to evaluate data of learning and memory. Results The score was significantly lower in stroke group compared with that of control group (17.71±5.59 vs. 24.80±5.05, P<0.01). The score was significantly lower in patients with lesions on left than that in patients with lesions on right (11.78 ± 1.48 vs. 22.17 ± 2.17, P<0.01). There was no significant difference in the score between hemorrhagic stroke group (16.50±6.59) and ischemic stroke group (18.46±5.01,P>0.05). Conclusion Marginal division of the striatum stroke can cause the associative learning and memory disorder, which is more serious in patients with lesions on left than that in patients with lesions on right.
ABSTRACT
To understand the relationship of neurotransmitter between the striatum and limbic system such as amygdaloid nucle-us and bed nucleus of the stria terminalis. 30 male Sprague Dawley rats were used. Immunohistochemical ABC method was per-formed to detect the expression of substance P (SP), calcitonin gene-related peptide (CGRP), leucine-enkephalin (L-enk),cholecyctokinin (CCK) and neuronal nitric oxide synthase (NOS) on seetions of the brain. Some transmitters including substanceP, calcitonin gene-related peptide and cholecyctokinin were mainly distributed at the marginal division of the striatum. Theleucine-enkephalin was mainly distributed at the globus pallidus and was secondly distributed at the marginal division of the stria-tun. The neuronal nitric oxide synthase was mainly distributed at caudate putamen and the marginal division. All these transmit-ters were not only distributed at amygdaloid nucleus and bed nucleus of the stria terminalis, but also had fibers connection amongthe amygdaloid nucleus, marginal division and bed nucleus of the stria terminalis. CONCLUSION: There were special fibersconnection between the marginal division and other basal ganglia nucleus or the limbic system. The marginal division may beplayed some important functions of basal ganglia and limbic system.
ABSTRACT
Using the immunohistochemical method combined with tract tracing techniques, a new subdivision, the marginal division, was found in the striatum of the rat. In this subdivision, substance P, enkephaline and dynorphin B terminals were densely localized. The present study investigated the synaptic organization of the substance P-like immunoreactive nerve terminals in the marginal division. Four major types of substance P immunoreactive synapses were identified. Axodendritic and axospinous synapses were the most common ones. Compound synapses with more than two synaptic components were also observed. One axo-axonic synapse was present. Both symmetric and asymmetric substance P-like immunoreactive synapses were seen in the marginal division. The existence of asymmetric synapses, small postsynaptic dendrites and axo-axonic synapses, distinguished the substance P-like immunoreactive nerve terminals in the marginal division from those in the other part of the striatum. The characteristics and complexity of the synaptic organization suggested that the substance P-like immunoreactive nerve terminals in the marginal division probably orginate from a different source and have a different function, as compared to those in the rest part of striatum.