ABSTRACT
As the main pollutant of food crops, T-2 toxin has toxic effects on human and animal digestive system, nervous system, reproductive development and so on. In Kashin-Beck disease related areas in China, the etiological substance of Kashin-Beck disease is the abnormal accumulation of T-2 toxin in the grain produced in the endemic area. The prevention and treatment of Kashin-Beck disease has achieved remarkable results through the comprehensive prevention and control measures, such as changing the production and life style, grain exchange, etc., but there are still pathogenic factors in the external environment of the disease area. In this paper, the metabolic kinetics of T-2 toxin is reviewed, and the physicochemical properties, distribution in the body, metabolic kinetics, biotransformation and damage of T-2 toxin and its metabolites to various organs are described, so as to provide new thinking for the study on the effects of T-2 toxin on various organs of the body.
ABSTRACT
Arylamine N-acetyltransferase(NATs)is one of phase Ⅱ drug-metabolizing enzymes,which is very important in drug metabolizing and detoxification.It may become a new target for studying pharmacological effects.The study on NATs is hitherto its crystal structure or polymorphisms among different species,different ethnicity,same species,and same ethnicity.However,the study on its physiological and pharmacological effects is unwontedly reported.In the paper the research work on NATs is summarized from the following aspects:the structure,carcinogenic mechanism,endogenous activities,inhibitor,substitute products,metabolic kinetics,polymorphism and relation with diseases,and detected methods of NATs.