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OBJECTIVE:To explore the effect of micro-powder technique on the application of traditional Chinese medicine. METHODS:The physical property of the micro-powder and its effect on curative effect, toxicity and pharmaceutical engineering were analyzed. The efficacy of traditional Chinese medicine micro-powder was compared with traditional pieces and decoction. RESULTS:As compared with traditional pieces and decoction, traditional Chinese medicine micro-powder represented many advantages but there were a series of problems such as the change of curative effect and the toxicity in the process of application. CONCLUSION:The micro-powder technology is beneficial exploration to the traditional Chinese medicine dosage-form reform, which should be paid attention and studied.
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Objective To investigate the effect of hirudo micropowder on inflammatory factors in rats with cerebral ischemia-reperfusion injury.Methods Rats were randomly divided into sham-operation group,model group,coarse powder hirudo group,high-,middle-and low-dose micropowder hirudo groups.The corresponding drugs were given to the rats for 10 days by intragastric administration.Then middle cerebral artery occlusion(MCAO) model was made by suture method.The changes of inflammatory factors were observed.Results The level of intercellular adhesion molecule 1(ICAM-1) in high-dose micropowder hirudo group was lower than that in coarse powder hirudo group,and the level of platelet-derived growth factor(PDGF) in middle-and high-dose micropowder hirudo groups was also lower than that in coarse powder hirudo group obviously(P
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Objective: To make out effects of different absorbents, mositure and alcohol amount on the absorption of lipophilic extract of Rhizoma Alismatis in Jinzhe Guanxin Capsules in order to solve its preparation procedure problem. Methods: The absorbent activity and absorbed dose were determined. Results: The moisture of lipophilic extract of Rhizoma Alismatis was lower than 25%, 95% alcohol amount for every gram was 0.25～ 0.5 ml when aluminum hydroxide gel was used as an absorbent. This was the best procedure condition.Conclusion: Jinzhe Guanxin Capsule preparad by aluminum hydroxide gel conforms with the preparation quality requirement.
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AIM: To provide a HPLC fingerprint of Fructus aurantii micropowder in order to create a basis for(identification.) METHODS: With the help of computer similarity evaluation,Seventeen kinds of Fructus aruantii sample were pulverized and micronized separately,then were extracted by methanol and compared correlation between both extracts. RESULTS: In methanol extraction,contents of aurantiamarin,hesperidin and neohesperidin in micropowder were more than that in pulverized powders,correlation of both HPLC fingerprint was 0.9~1.0. CONCLUSION: The method established can be used for identifying and evaluating crud drug of Fructus aurantii,and further prove that micronization is beneficial to increasing flavonoid dissolution.
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AIM: To compare the ginsenoside Rb 1 content in different granularity of Radix Panacis Quinquefolii in order to confine Chinese medicine by ultramicro powder technique. METHODS: HPLC was used to determine ginsenoside Rb 1 in micropowder of Radix Panacis Quinquefolii.RESULTS:The contents of ginsenoside Rb 1 in micropowder of Radix Panacis Quinquefolii pulverized in normal and low temperature were increasing with particle size reduction, and the content in low temperature pulverization was distinctly higher than that in normal temperature pulverization. CONCLUSIONS: Low temperature pulverization of Radix panacis Quinquefolii is superior to processing at temperature.
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AIM: To optimize the milling and extraction rate for Naolisu Granules (Rhizoma Acori Tatarinowii, Radix Notoginseny, Pheretima Radix et Rhizoma Rhei, Radix Curcuma, Radix Ginserg Rubra, etc.). METHODS: The granularity of powder was determined by different micropowder processes. The process was studied by orthogonal design with the content of volatile oil, the yield of extract and the content of emodin. RESULTS: The optimum process of milling was that coarse powder was micropulverized for 20 min at -8℃ ～ -12℃ . The optimum extraction of volatile oil was distillated for 4 hs after volatile medical materials were macerated for 1h with 7 times amount of water. The optimum process of percolation was percolated by 300mL of 75% alcohol with 3.0mL?kg -1 ?min -1 after the medical material powders were macerated for 6 hs. CONCLUSION: These optimum processes are suitable for preparation of Naolisu Granules.
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AIM: To investigate the influence of microwave-assisted extraction on flavone contents of Pollen Tyhae micropowder. METHODS: Ultraviolet spectrophotometer and HPLC were applied to analyze Pollen Tyhae micropowder, total flavon and isorhamnetin-3-O-neohespridoside were adopted as the marker, respectively. RESULTS: Appropriate conditions of microwave-assisted extraction included: extraction time of 8min, ethanol concentration of 70%, Solid/liquid ratio of 1∶18 (g?mL -1) and the power of microwave oven of 540w. CONCLUSION: Compared with normal reflux method, microwave-assisted extraction of Pollen Typhae micropowder is more useful and can improve the extraction rate the reduce the extracting time.
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OBJECTIVE:To study the direct powder compression technology of Angelica micropowder. METHODS: The formula of Angelica micropowder was optimized by mixture uniform design with tablet weight variation and friability as restrictive conditions, and a regression equation was established based on the comprehensive grading on the hardness and disintegration to figure out the optimal solution. DPS software was applied in the calculation. RESULTS: Prepared by the direct powder compression technology, the optimal formula of Angelica micropowder was obtained as follows: the hardness of the optimized tablet could reach as high as 75 N and the disintegrating time was about 10.24 min, with smooth and intact surface. CONCLUSION:The technology is reasonable in formulation and satisfactory in molding, and it can serve as theoretical basis for the production of Angelica tablets.