ABSTRACT
Objective To investigate the clinical effect of laparoscopy combined with leuprolide on patients with mild endometriosis and infertility and effects on fertility function of patients. Methods A total of 60 patients with mild endometriosis and infertility in our hospital were randomly divided into the control group (n=30) and the observation group (n=30). The control group was treated with laparoscopic surgery, the observation group was treated with leuprorelin treatment, and the levels of FSH, E2, luteinizing hormone and PROG were tested by automatic biochemical analyzer between two groups before and after treatment, the pregnancy rate as assessment of reproductive function in patients. Clinical curative effect and effect on fertility of 2 groups were compared. Results Levels of FSH, E2, LH and PROG in the observation group were lower than those in the control group (P<0.05) in 3 months after treatment, and the pregnancy rates in the observation group after 1 months, 2 months and 3 months were higher than that in the control group (P<0.05). Conclusion The treatment of Laparoscopy combined with Leuprolide for mild endometriosis and infertility in patients has ideal effect, and is worthy of popularization and application.
ABSTRACT
OBJECTIVE: The aim of this study is to assess the IVF/ICSI outcomes of infertile women with minimal to mild endometriosis associated and unexplained infertility. METHOD: We performed a retrospective analysis of 513 (IVF/ICSI) cycles with minimal to mild endometriosis associated infertility, 338 cycles with unexplained infertility, 351 cycles with tubal factor infertility as controls between Jan. 1997 and Apr. 2004. Exclusion criteria for study were: age>36 yrs old, the number of oocytes retrieved 20 mIU/ml, patients with nonobstructive azoospermia, polycystic ovarian syndrome. RESULTS: The incidence of primary infertility was significantly higher in minimal to mild endometriosis (72.3%) and unexplained (68.5%) than tubal factor (31.2%) (p<0.0001). There was no difference in fertilization rate between minimal to mild endometriosis associated infertility and unexplained infertility. But minimal to mild endometriosis associated infertility showed significantly lower fertilization rate and the number of total embryos than tubal factor infertility (62.3+/-21.2% vs. 68.8+/-17.6% (p<0.0001), 8.38+/-5.0 vs. 9.81+/-5.2 (p<0.0001)). But the number of good quality embryos was similar. Clinical pregnancy rates of minimal to mild endometriosis associated, unexplained, and tubal factor infertility was 32%, 35.8%, 39.9% and implantation rates was 13.5+/-23.3, 14.3+/-23.6, 16.1+/-23.5, respectively. CONCLUSION: The IVF/ICSI outcomes of minimal to mild endometriosis associated infertility is comparable to those of unexplained infertility with respect to clinical pregnancy rates, implantation rates, and live birth rates. And we suggest that IVF should be considered earlier in patients with minimal to mild endometriosis associated and unexplained infertility because of significantly decreased fertilization rates and longer duration of infertility.