Simulation of Subgroup Analysis Methods with Longitudinal Data Containing Measurement Errors and Missingness / 中国卫生统计

Objective To develop a subgroup analysis method that can simultaneously deal with longitudinal data containing measurement errors and dropouts.Methods Subgroup analysis was carried out based on a threshold regression model.A new generalized unbiased estimation equation is constructed by using the independence between repeated measurements to deal with measurement errors and introducing an inverse probability weighting matrix to deal with missing response.Results The computer stochastic simulation shows that the proposed estimation method is effective in dealing with measurement errors and dropouts,and has smaller bias and mean square error than the generalized estimation equation method without correcting measurement errors or dropouts.Conclusion In subgroup analysis,when there are measurement errors in covariables and missing values in response variables,it is usually necessary to deal with the measurement errors and missing values in order to obtain reliable parameter estimation.

The efficacy of modified everStick C&B fiber resin bonded bridge in the restoration of incisor missing teeth in senile patients / 实用口腔医学杂志

Objective:To evaluate the clinical effects of modified everStick C&B fiber resin bonded bridge in the restoration of inci-sor missing teeth in senile patients.Methods:32 patients over 65 years with incisor loss old were included.13 of them were with missing maxillary incisors and 19 with missing mandibular incisors.13 had 1 missing tooth,11 had 2,5 had 3 and 3 had 4 missing teeth.The abutment was loose in 24 cases and not loose in 8 cases.All patients were treated with modified everStick C&B fiber resin bonded bridge repair.Re-examination was conducted at 6,12 and 18 months after completion of repair.The re-examination includ-ed 6 indexes including prosthesis debonding,fracture,color change,defect,abutment loosening and periodontal tissue inflamma-tion.The patients'satisfaction was investigated 6 months after the repair was completed.The investigation included 3 indexes:whether the treatment was comfortable,whether the aesthetic effect was satisfactory,and whether the pronunciation and chewing were comfortable after the repair.Results:The 32 patients were reexamined 6 months after completion of the repair,and all 6 indexes were grade A.Reexamination at 12 months showed that 1 case of treated defect was grade B,2 cases of abutal periodontal tissue in-flammation was grade B,and the rest indexes were grade A.Reexamination at 18 months showed that 1 case of treated defect was grade B,3 cases of abutal periodontal tissue inflammation was grade B,and the rest indexes were grade A.All the 2 cases of grade B defects reached grade A after resin filling.All the 5 cases of abutal periodontal tissue inflammation grade B reached grade A 5-7 days after periodontal cleaning.All 3 indicators in the patient satisfaction survey were graded A.Conclusion:The modified ever-Stick C&B fiber resin bonded bridge is effective in the restoration of incisor missing teeth in senile patients.

Effect of arch shapes and missing second premolars on anchorage during maxillary molar distalization with clear aligners / 中国组织工程研究

BACKGROUND:The reciprocal force generated by the molar distalization with clear aligners can lead to anchorage loss.The effect of arch shapes and missing second premolars on anchorage has not been reported. OBJECTIVE:To analyze the effect of arch shapes and missing second premolars on anchorage during molar distalization with clear aligners using the finite element method. METHODS:Cone-beam CT data from an adult male were acquired from the database to establish the maxilla-upper dentition-periodontium-rectangular attachment-clear aligner model.The distal movement amount designed on the bilateral second molars was set to 0.25 mm.First,there were two groups in the study:second premolar bilateral presence and absence groups.Then,four subgroups in each group were created:tapered arch,ovoid arch,square Class Ⅱ Division 1 arch,and Class Ⅱ Division 2 arch groups.The Ansys software was used to calculate the displacement of the anchorage tooth and the stress of the periodontal ligament. RESULTS AND CONCLUSION:Mesial tipping and extrusion of first molars and premolars,labial inclination and intrusion of anterior teeth occurred during the upper second molar distalization with clear aligners.When the bilateral second premolars were missing,the mesial displacement of first molars increased significantly while that of first premolars and anterior teeth decreased in all groups.The square Class Ⅱ Division 1 arch group showed the least anterior labial inclination,while the tapered arch group showed the most.There was no significant difference between the ovoid arch group and the tapered arch group.Moreover,the magnitude of tipping in the square Class Ⅱ Division 2 arch group was slightly higher than that in the Class Ⅱ Division 1 arch group.The stress of the periodontal ligament of the anchorage teeth was concentrated on the cervical and apical regions of the teeth.And the lowest stress level was detected in the square arch group.Compared with the other groups,the stress on the labial cervical area of the periodontal ligaments was also significantly relieved in the square arch group.To conclude,the square arch is more favorable in terms of anterior anchorage control and periodontal ligament stress distribution.Anterior labial inclination efficiency can be increased in cases of Class Ⅱ Division 2 by designing the anterior labial inclination in conjunction with molar distalization.If the second premolar is missing during molar distalization,it is not conducive to opening up the space in the area of the missing tooth.

Restoration of a dental defect in a patient with ectodermal dysplasia: a case report and literature review / 口腔疾病防治

Objective@#To explore the treatment options for congenitally missing teeth in patients with ectodermal dysplasia and provide a clinical reference.@*Methods@#A patient with ectodermal dysplasia with a concave midface, anterior protrusion of the chin, and underdevelopment of the lower third of the face presented with congenital loss of multiple maxillary teeth, malocclusion of the remaining teeth, congenital loss of mandibular dentition, small dental arches, and upper and lower alveolar bone hypoplasia. The patient was treated by means of a removable partial maxillary prosthesis, implants in the anterior region of the lower mandible designed with the assistance of digital guides, and bar-clamped implant-overlay prostheses. A literature review of the protocol for the treatment of this condition was also conducted.@*Results@#In addition to good retention and stability after denture wear, an excellent occlusal relationship, improvement of the patient's facial appearance, including upper and lower lip fullness, more equal balancing of the lower and middle 1/3 of the face, and improved masticatory function were achieved. The results of the literature review showed that patients with ectodermal dysplasia who are congenitally edentulous usually have a complex intraoral situation that makes restoration difficult, and common restorative modalities for these patients include fixed bridges, removable partial dentures, complete dentures, overdentures, and implant prostheses, which need to be selected according to the actual intraoral situation of each patient. Currently, there is no consensus on the treatment of congenitally missing teeth in patients with ectodermal dysplasia, and some scholars have suggested that fixed restorations be recommended for patients with fewer missing teeth, while the option of removable or implant-covered denture restorations should be given to patients with more missing teeth, with removeable prostheses for underage patients that are replaced with permanent fixed prostheses when the jaws have stabilized.@*Conclusion@#In patients with ectodermal dysplasia with congenital tooth loss, all factors should be taken into account, and an individualized restorative plan should be developed.

Genome-wide association analysis of agronomic traits related to eggplant fruits: a review / 生物工程学报

Eggplant is an important horticultural crop and one of the most widely grown vegetables in the Solanaceae family. Eggplant fruit-related agronomic traits are complex quantitative traits with low efficiency and long cycle time for traditional breeding selection. With the rapid development of high-throughput sequencing technology and bioinformatics tools, genome-wide association study (GWAS) has shown great application potential in analyzing the genetic rules of complex agronomic traits related to eggplant fruits. This paper first reviews the progress of genome-wide association analysis in eggplant fruit shape, fruit color and other fruit-related agronomic traits. Subsequently, aiming at the problem of missing heritability, which is common in the genetic studies of eggplant quantitative traits, this paper puts forward the development strategies of eggplant GWAS in the future based on the hot spots of application of four GWAS strategies in the research of agronomics traits related to eggplant fruits. Lastly, the application of GWAS strategy in the field of eggplant molecular breeding is expected to provide a theoretical basis and reference for the future use of GWAS to analyze the genetic basis of various eggplant fruit-related traits and to select fruit materials that meet consumer needs.

Adaptación y validación al contexto argentino de la escala de fear of missing out / Adaptation and Validation of the Fear of Missing Out Scale to the Argentine Context / Adaptação e validação ao contexto argentino da escala fear of missing out

El presente trabajo se propone examinar las propiedades psicométricas de la adaptación al contexto argentino de la escala de fear of missing out (FoMO, miedo a perderse algo) en una muestra compuesta por residentes del Área Metropolitana de Buenos Aires (amba, Argentina). La escala permite medir un único factor que establece el grado en que las personas se encuentran pendientes de las actividades ajenas en comparación con las propias. Del estudio participaron 416 personas con edades entre 18 y 66 años (M = 28.82) y de diferentes géneros (hombres = 25 %; mujeres = 75 %). Los análisis confirmatorios arrojaron valores superiores a 0.90 para los índices ifi, nnfi y cfi, y para el rmsea, valores inferiores a 0.08. La consistencia interna evaluada a partir de los estadísticos alfa ordinal y omega de McDonald fue aceptable (α = 0.77; ω = 0.99). La evidencia de validez externa de la escala demostró asociaciones significativas con la escala de autoestima de Rosenberg (rses), de manera consistente con estudios previos.

The present study examines the evidence of validity and reliability of the Argentine version of the fear of missing out (FoMO) scale in a sample of residents in the Area Metropolitana de Buenos Aires (amba) (Argentina). The scale consists in a single factor that allows us to measure the degree to which people are aware of other people's activities compared with their own experiences. This study involved 416 individuals with ages between 18 and 66 years (M = 28.82) and of different genders (Male = 25 %; Female = 75 %). The confirmatory factor analysis yielded values higher than 0.90 for the ifi, nnfi, and cfi indices and the rmseavalues lower than 0.08, figures considered as adequateadjustment indicators. The internal consistency was evaluated from Cronbach's Alpha and the McDonald's Omega statistic, obtaining acceptable figures (α = 0.77; ω = 0.99). The external validity analysis showed sig-nificant associations with the Rosenberg self-esteemscale, following previous studies

Este artigo tem como objetivo examinar as proprieda-des psicométricas da adaptação ao contexto argentino da escala fear of missing out (FoMO, medo de perder alguma coisa) em uma amostra composta por residen-tes da Região Metropolitana de Buenos Aires (rmba) (Argentina). A escala permite medir um único fator que estabelece o grau de conhecimento das pessoas sobre as atividades dos outros em comparação com as suas próprias. Participaram do estudo 416 pessoas com idades entre 18 e 66 anos (M = 28.82) e de diferentes gêneros (homens = 25 %; mulheres = 75 %). As aná-lises confirmatórias produziram valores superiores a 0.90 para os índices ifi, nnfi e cfi e valores inferiores a 0.08 para o rmsea. A consistência interna avaliada pelas estatísticas alfa e ômega ordinal de McDonald foram aceitáveis (α = 0.77; ω = 0.99). Evidências de validade externa da escala demonstraram associações significativas com a escala de autoestima de Rosenberg (rses), consistentes com estudos anteriores

Algorithm for pediatric orbital blowout fractures: a 20-year retrospective cohort study

Abstract Objective Pediatric orbital blowout fractures can include pathologies that seem mild but require urgent release; serious sequelae can occur with standby surgery or conservative treatment. We sought to validate an algorithm for the treatment of pediatric orbital blowout fractures. Methods This retrospective cohort study included 61 pediatric patients, aged 18 years or younger, treated for pure orbital blowout fractures according to the algorithm from April 1, 2000, to August 31, 2020, at the Japanese Red Cross Asahikawa Hospital. Results There were 52 males (85%). Median age was 14 years (range, 5-18 years). There were 9 patients categorized as needing urgent release, 16 as needing repair, and 36 as needing conservative treatment. Mean follow-up ocular movement was 98.0 (95% Confidence Interval [95% CI], 96.8-99.2). Postoperative diplopia was not observed in 96% (79.6%-99.9%) of patients, better than in previous studies. A higher proportion of patients aged 0-12 years needed urgent repair than those aged 13-18 years (Odds Ratio [OR] = 14.2; 95% CI 1.6-683.4; p= 0.0046). There were no differences in Hess area ratio by age group. Conclusion Clinical results with the algorithm were satisfactory. The algorithm is suitable for treatment of pediatric orbital blowout fractures. Level of evidence 4.

Ghost of Medical Gaslighting

Medical gaslighting is when the actual symptoms of patients are dismissed or downplayed by medical professionals. It occurs frequently among patients suffering from chronic illnesses for which medical science gives no authoritative diagnostic protocol or effective treatment and those from populations underrepresented in clinical trials such as the female gender, specific races and ethnicity, third gender and patients with disability. Gaps in scientific knowledge and missing empathy have been cited as possible reasons. Respecting patient symptoms, accepting epistemic humility and investing in research may be possible solutions for this disharmony.

Research progress of fear of missing out in mobile social media among college students / 中国学校卫生

Abstract@#Fear of missing out is an emerging type of anxiety disorder in the context of the Internet and has showed significant impacts on physical and mental health of college students. The review provides an overview on the connotation, extension, and adverse effects, as well as potential underlying mechanisms of fear of missing out in mobile social media among college students, which aims to highlight future attention, as well as prevention and intervention reference on fear of missing out in college students.

Effect of basic psychological needs satisfaction on phubbing behavior among high school students: the mediating effect of fear of missing out and mobile phone addiction / 中华行为医学与脑科学杂志

Objective:To investigate the mediating roles of the fear of missing out and mobile phone addiction between the basic psychological needs satisfaction and phubbing behavior among high school students.Methods:In April 2022, a cross-sectional design survey was conducted on 14 666 high school students. All participants were evaluated by the basic psychological needs scales(BPNS), generic scale of phubbing(GSP), trait-state fear of missing out scale(T-S FOMOS) and mobile phone addiction index(MPAI). The SPSS 26.0 software was used to conduct common method deviation test, descriptive statistics, and correlation analysis.PROCESS 4.1 was used to construct the model, and the Bootstrap method was used to test for mediating effects.Results:(1)Among the 14 036 high school students, there were 1 752 (12.48%) students who were addicted to mobile phones.There were significant differences in gender in the scores including BPNS(boy: 4.43±0.79, girl: 4.36±0.79), GSP(boy: 2.72±1.01, girl: 2.76±1.03) and T-S FOMOS(boy: 1.73±0.60, girl: 1.84±0.64), ( t=5.22, -10.58, -2.78, all P<0.01). Among different grades, there were significant differences in the scores of BPNS, T-S FOMOS, MPAI, and GSP( F=25.43, 39.50, 53.45, 14.59, all P<0.01). (2)Basic psychological needs score were positively correlated with fear of missing out, mobile phone addiction and phubbing( r=-0.432--0.294, all P<0.01). Phubbing were negatively correlated with fear of missing out and mobile phone addiction( r=0.744, 0.538, both P<0.01). Fear of missing out were negatively correlated with mobile phone( r=0.646, P<0.01). (3)The basic psychological needs satisfaction had a direct effect on phubbing behavior, and the effect value was -0.188 (95% CI: -0.173--0.204). The mediating effect of fear of missing out between the basic psychological needs satisfaction and phubbing behavior was -0.035(95% CI: -0.028--0.042). The mediating effect of mobile phone between the basic psychological needs satisfaction and phubbing behavior was -0.203(95% CI: -0.191--0.214). Fear of missing out and mobile phone addiction played a chain mediating role between them, and the mediating effect value was -0.134(95% CI: -0.125--0.143), which accounted for 23.93%(-0.134/-0.560) of the total effect. Conclusion:The high level basic psychological needs satisfaction can alleviate the occurrence of phubbing behavior. It may be achieved by decreasing fear of missing out and reducing mobile phone addiction.

Reinforce revealing missing heritability in the gene of inherited retinal diseases / 中华眼底病杂志

Inherited retinal diseases (IRD) are a group of genetic disorders with high genetic and clinical heterogeneity. Genetic diagnosis has become one essential method for patients with IRD in their clinical management. So far, about 30% of the patients with IRD cannot get molecular diagnosis (no pathogenic variant detected or only mono-allele variant identified in AR genes) using target or whole exome sequencing. Most missing heritability or variants for these patients were variants located in no-coding regions (deep intron or promoter regions) and structure variants of the known IRD genes. It is more challenge to reveal this kind of missing variants, which need using whole genome sequencing combined with other cellular or molecular assays.

Trajectory of the development of caries in the permanent dentition of 12- to 16-year-old students based on a latent class growth model analysis in Liuyang / 口腔疾病防治

Objective@# To explore the trajectory of the development of permanent caries in 12- to 16-year-old students in Liuyang and to provide a reference for the prevention and management of caries.@*Methods@#Primary and secondary school students who were registered within the Liuyang jurisdiction were screened for caries from September to November by the Liuyang Center for Disease Control and Prevention. A total of 7 297 students between the ages of 12 and 16 years with complete permanent dentition caries monitoring records and traceable deciduous dentition caries monitoring records were selected from 2013 to 2019, and a zero-inflated negative binomial-latent class growth model (ZINB-LCGM) was established to describe the trajectory of the development of individual caries using the decayed missing filled teeth (DMFT) indicators. @*Results@# DMFT of 12- to 16-year-old students in Liuyang were mainly decayed teeth (DT), with the majority occurring in the first permanent molar. According to the ZINB-LCGM model, the students were classified into three latent categories, "slow growth pattern" (28.55%), "rapid growth pattern" (6.59%), and "stable pattern" (64.86%), which followed different nonlinear caries growth trajectories. Females with deciduous teeth caries were more likely to have trajectories showing a “rapid growth pattern” and a “slow growth pattern”. There were significant differences in the trajectories between men and women, as well as between those with and without primary dentition caries. @*Conclusion @# The trajectory of the development of caries in 12-16-year-old students shows heterogeneity in terms of different developmental patterns of latent categories, suggesting that females with deciduous dental caries should receive more attention.

The mediating role of FoMO and the moderating role of narcissism in the impact of social exclusion on compulsive buying: a cross-cultural study

Abstract Background There is an interrelationship between the concepts of social exclusion, compulsive buying behavior, fear of missing out (FoMO), and narcissism. Nevertheless, the extent to which these concepts mediate or moderate their relationships with each other has not been efficiently investigated. Objective This research aims to investigate how FoMO mediates and narcissism moderates the correlation between social exclusion and compulsive buying behavior. In addition, the research aims to test a conceptual model and highlight the differences that may occur in the conceptual model proposed in two different countries. Methods This model was analyzed among 1007 university students (Turkey =506, Denmark =501). The study used scales to measure social exclusion, compulsive buying behavior, FoMO, and narcissism. The study employed PROCESS Model 4 to analyze direct and indirect (mediation) effects and PROCESS Model 59 to assess conditional (moderation) effects. Furthermore, the Johnson-Neyman technique was utilized to investigate interaction terms. Results The findings indicate that those who face social exclusion tend to participate more in compulsive buying, and this connection is partly explained by FoMO. This suggests that individuals who encounter social exclusion may have an increased likelihood of experiencing FoMO, which may subsequently contribute to compulsive buying behavior. Furthermore, the moderating effect of narcissism differed between the Turkey and Danish samples. Specifically, in the Turkey sample, narcissism only modified the connection between social exclusion and FoMO, while in the Danish sample, it impacted both the connection between social exclusion and FoMO and the connection between FoMO and compulsive buying. Conclusion The obtained results show that the regulating role of narcissism is different in Turkey and Denmark within the conceptual model we studied.

Dental Caries and their Relation to HbA1c in Adults with Type 2 Diabetes Mellitus

Diabetes mellitus with poor glycemic control is often associated with dental caries. We aim to assess the relationship between dental caries and HbA1c levels among adults with type 2 diabetes (T2D) in Chennai. A cutoff of HbA1c ?7.0 to 7.9% (53–63 mmol/mol) was used to define Group 1 (n = 113) as moderately controlled and HbA1c ?8.0% (64 mmol/mol) to define Group 2 (n = 228) as poorly controlled T2D. The absolute numbers of decayed, missing, and filled teeth were examined to calculate the decayed, missing and filled teeth index. Group 2 had a significantly higher percentage (48.2%) of decayed teeth when compared to Group 1 (28.3%). Group 2 had a 2.65 times higher risk of decayed teeth when adjusted for mean carbohydrate consumption, sweets consumption, oral hygiene, and brushing habit. T2D with higher HbA1c levels is associated with an increased number of decayed teeth. Hence, there is a need for monitoring dental status in T2D as earlier treatment may prevent or delay decay teeth.

Assessing consequences of untreated dental caries using pufa/PUFA index among 6–12 years old schoolchildren in a rural population of Kerala

Context: Dental caries is the most common dental disease of childhood. India with a population of more than 135 crores accounts for a high proportion of dental morbidity. Poor oral health has a significant impact on quality of life, especially in rural areas. The consequences of untreated dental caries include pain, abscess, and space infections which may lead to loss of function and school hours. These consequences are of utmost important while planning a community dental care program. Aims: To assess the prevalence of dental caries, caries experience, and severity of dental caries among 6–12 years old schoolchildren in the rural areas of Kollam District, Kerala State. Settings and Design: A community school-based, descriptive, cross-sectional study in the rural areas of Kollam District. Materials and Methods: A cross-sectional study was carried among 2194 schoolchildren in the rural areas of Kollam District in the age group of 6–12 years. Children from eight randomly selected schools were examined for pufa/PUFA and dmf/DMF indices. Statistical Analysis Used: SPSS version 17.0, Mann-Whitney, t-test, KruskalWallis test. P < 0.05 was considered statistically significant. Results and Conclusions: Overall caries prevalence among the total population was found to be 74%. The prevalence of caries in the deciduous dentition was 61% and a mean decayed, missing, filled teeth value of 2.74 ± 3.200 and for the permanent dentition the caries prevalence of 26.8% and a mean Decayed, Missing, Filled Teeth of 0.66 ± 1.360 were observed. The prevalence of untreated dental caries (pufa/PUFA) was 40.8%. The pufa prevalence in deciduous dentition was 38.3% with a mean pufa of 0.99 ± 1.679. Moreover, the PUFA prevalence in permanent dentition was 4.1% with a mean PUFA of 0.06 ± 0.349. The highest prevalence of untreated dental caries (pufa/PUFA) was found in the 7 years' age group (52%) and the lowest in 12 years' age group (22.4%).

F approach algorithm in missing landmark problem / Aproximación al algoritmo F en punto de referencia perdido

SUMMARY: Missing data may occur in every scientific studies. Statistical shape analysis involves methods that use geometric information obtained from objects. The most important input to the use of geometric information in statistical shape analysis is landmarks. Missing data in shape analysis occurs when there is a loss of information about landmark cartesian coordinates. The aim of the study is to propose F approach algorithm for estimating missing landmark coordinates and compare the performance of F approach with generally accepted missing data estimation methods, EM algorithm, PCA based methods such as Bayesian PCA, Nonlinear Estimation by Iterative Partial Least Squares PCA, Inverse non-linear PCA, Probabilistic PCA and regression imputation methods. Landmark counts were taken as 3, 6, 9 and sample sizes were taken as 5, 10, 30, 50, 100 in the simulation study. The data are generated based on multivariate normal distribution with positively defined variance-covariance matrices from isotropic models. In simulation study three different simulation scenarios and simulation based real data are considered with 1000 repetations. The best and the most different result in the performance evaluation according to all sample sizes is the Min (F) criteria of the F approach algorithm proposed in the study. In case of three landmarks which is only the proposed F approach and regression assignment method can be applied, Min (F) criteria give best results.

RESUMEN: Los datos faltantes pueden ocurrir en todos los estudios científicos. El análisis estadístico de formas involucra métodos que utilizan información geométrica obtenida de objetos. La entrada más importante para el uso de información geométrica en el análisis estadístico de formas son los puntos de referencia. Los datos que faltan en el análisis de formas se producen cuando hay una pérdida de información sobre las coordenadas cartesianas históricas. El objetivo del estudio es proponer el algoritmo de enfoque F para estimar las coordenadas de puntos de referencia faltantes y comparar el rendimiento del enfoque F con métodos de estimación de datos faltantes generalmente aceptados, algoritmo EM, métodos basados en PCA como Bayesian PCA, Estimación no lineal por Iterative Partial Least Squares PCA, PCA no lineal inverso, PCA probabilístico y métodos de imputación de regresión. Los recuentos de puntos de referencia se tomaron como 3, 6, 9 y los tamaños de muestra se tomaron como 5, 10, 30, 50, 100 en el estudio de simulación. Los datos se generan en base a una distribución normal multivariada con matrices de varianza-covarianza definidas positivamente a partir de modelos isotrópicos. En el estudio de simulación se consideran tres escenarios de simulación diferentes y se consideran datos reales basados en simulación con 1000 repeticiones. El mejor y más diferente resultado en la evaluación del desempeño según todos los tamaños de muestra es el criterio Min (F) del algoritmo de enfoque F propuesto en el estudio. En el caso de tres puntos de referencia, que es solo el enfoque F propuesto y se puede aplicar el método de asignación de regresión, los criterios Min (F) dan mejores resultados.

Family function and fear of missing out among college students: the chain mediating effect of relatedness need-frustration and self-control / 中华行为医学与脑科学杂志

Objective:To explore the chain mediating effect of relatedness need-frustration and self-control between family function and fear of missing out (FoMO) in college students.Methods:A sample of 409 college students from five universities in Guangdong province was surveyed with family assessment device (FAD), relatedness need-satisfaction and frustration scale, self-control scale (SCS), and fear of missing out scale.Common method bias test, Pearson correlation analysis and Hierarchical regression analysis were conducted to analyze the data using SPSS 26.0 software, and PROCESS V3.5 macro program was used to test the mediating effect.Results:(1) The total scores of family function, relatedness need-frustration, self-control and FoMO were(166.01±16.08), (9.39±2.51), (37.88±6.27)and(56.38±6.59), respectively. (2) Family function was negatively correlated with relatedness need-frustration ( r =-0.43, P<0.01), positively correlated with self-control( r =0.43, P<0.01), and negatively correlated with FoMO ( r =-0.39, P<0.01). Relatedness need-frustration was negatively correlated with self-control ( r =-0.37, P<0.01), and positively correlated with FoMO( r =0.38, P<0.01). Self-control was negatively correlated with FoMO( r =-0.42, P<0.01). (3)The direct effect of family function on FoMO was -0.17(95% CI =-0.27--0.07). Family function affected FoMO through three paths. The separate mediation effect of relatedness need-frustration was -0.09(95% CI =-0.14--0.05), the separate mediation effect of self-control was -0.09(95% CI =-0.14--0.05), and the chain mediation effect of relatedness need-frustration and self-control was -0.03(95% CI =-0.04--0.01). Conclusion:Family function not only directly affects FoMO, but also indirectly affects FoMO through relatedness need-frustration and self-control.

The pathogenesis and clinical features of GCM2 mutation related primary hyperparathyroidism / 中华内分泌代谢杂志

The majority of primary hyperparathyroidism (PHPT) are sporadic, and less than 10% of cases are hereditary or part of familial syndromes. Glial cell missing 2 (GCM2) was confirmed to be a new pathogenic gene of PHPT in 2016. At present, four GCM2 mutations have been confirmed to have certain correlations with familial or sporadic PHPT. The purpose of this review is to summarize the pathogenesis and clinical features of GCM2 mutation related primary hyperparathyroidism.

Cultivation and characterization of primary human parathyroid cells from patients with severe secondary hyperparathyroidism / 南方医科大学学报

OBJECTIVE@#To establish an cell model of hyperparathyroidism by isolation, in vitro culture, and identification of parathyroid cells from patients with secondary hyperparathyroidism (SHPT).@*METHODS@#The parathyroid gland tissues obtained from 10 patients with SHPT were dissociated by collagenase digestion for primary culture of the parathyroid cells. Morphological changes and growth characteristics of the cells were assessed by microscopic imaging and cell counting. The mRNA and protein expression levels of parathyroid hormone (PTH), calcium-sensing receptor (CaSR), and glial cells missing 2 (GCM2) in the primary and passaged cells were determined by immunofluorescence, qRT-PCR, and Western blotting.@*RESULTS@#Primary cultures of parathyroid cells were successfully obtained. The cells exhibited a high expression of PTH shown by immunofluorescence assay and had a population doubling time of approximately 71.61 h. PTH secretion in the second-passage (P2) cells was significantly lower than that in the primary (P0) and first-passage (P1) cells (P < 0.001). Despite a significant downregulation of CaSR mRNA (P=0.017) and protein (P=0.006) in P1 cells as compared with P0 cells, no significant differences were found in mRNA and protein expressions of PTH or GCM2 between the two cell generations.@*CONCLUSION@#Primary cultures of parathyroid cells isolated from SHPT patients by collagenase digestion show similar biological properties to the cells in vivo.

Evaluation of Taking-Medicine-Support Device for Inpatients / 社会薬学

In Japan, as a Social Security Reform measure against workforce decrease by 2040, robotic devices for nursing care and medication intake support have been utilised. However, evaluation reports about the robots and studies about their evaluation by patients are lacking. Therefore, we studied medication status with robotic assistance as well as patients’ evaluation of usability of robotic assistance. Participants were twelve patients whose median age was 73.0 (min 39.0-max 82.0), the median of number of drugs of a maximum intake day, which means the one of the week in which drugs are taken most, was 10.0 (min 4.0-max 17.0), and the median of maximum number of times to take drugs per day was 3.0 (min 1.0-max 4.0). Four were suspected of having dementia, based on the evaluation of their cognitive function tests. No patient missed any dose during the utilisation of the support device in taking medicine. All patients reported that the conditions of taking medicine and the recognition of the time to take it were improved. Therefore, the incorporation of support devices in taking medicine is expected to avoid missing to doses.