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Objective To observe the changes of serum clara cell protein?16 ( CC?16 ) and monocyte chemotaxis protein?1 (MCP?1) level in patients with acute respiratory distress syndrome (ARDS) and to explore their relationship with the disease severity and prognosis of ARDS??Methods One hundred and fourteen patients with ARDS who were admitted to Changzhi People′s hospital from January 2017 to March 2018 were selected as the subjects??They were divided into mild group ( n＝37),moderate group (n＝41) and severe group ( n＝36) according to the severity of ARDS??Sixty healthy persons in out?patient examination were selected as control group??The survival situation of patients in 4 weeks were recorded,the patients were divided into survival group ( n＝65) and death group ( n＝49) according to their survival situation??The age,gender,body mass index (BMI),smoking history,acute physiology and acute physiology and chronic health evaluation II ( APACHE II) score,sequential organ failure assessment ( SOFA) score, serum CC?16 and MCP?1 level were analyzed in each group??The relationship between serum CC?16,MCP?1 level and disease and prognosis of patients with ARDS were analyzed??Results With the increase of disease severity,APACHE II score, SOFA score and serum CC?16, MCP?1 level in patients with ARDS were significantly increased??The differences were statistically significant ( F＝1 216??886,1 339??247,290??879, 417??262; all P＝0??000)??The APACHE II score,SOFA score and serum CC?16,MCP?1 levels in the death group were (22??13± 2??47) scores,( 15??09 ± 1??97) scores,( 23??85 ± 4??27) μg／L, ( 36??64 ± 5??21) ng／L respectively,which were significantly higher than those in the survival group (18??25±2??35) scores,(13??23 ±2??03) scores,(17??34±4??13) μg／L,(27??93±4??88) ng／L,the differences were statistically significant (t＝8??538,4??905,8??211,9??146;all P＝0??000)??Pearson correlation analysis showed that there was a positive correlation between serum CC?16 level and MCP?1 level in patients with ARDS ( r＝0??589, P ＝0??000)??Meanwhile,the CC?16,MCP?1 were positive correlation with APACHE II score,SOFA score and mortality (CC?16:r＝0??504,0??549,0??472;P＝0??000,0??000,0??012;MCP?1:r＝0??493,0??528,0??435;P＝0??006, 0??000,0??025)??APACHE II score ( OR＝3??083,95%CI:0??025－1??364,P＜0??05),CC?16 ( OR＝5??403, 95%CI:0??011－6??561, P＜0??05) and MCP?1 ( OR＝2??892, 95%CI: 0??034－1??619, P＜0??05) were all closely related to ARDS death??CC?16 independent detection, MCP?1 independent detection and the two combined detection predicted the under?curve area, sensitivity and specificity of ARDS patients with in 4 weeks were 0??830, 82??35% and 72??16%; 0??719, 79??25% and 72??19%; 0??866, 85??06% and 80??72%respectively??Conclusion CC?16,MCP?1 are abnormally high expression in serum of patients with ARDS, and its levels are closely related to the severity and prognosis of patients with ARDS??CC?16 combined with MCP?1 detection has high diagnostic value for patients with ARDS,which can be used as an effective index to judge the disease and prognosis of patients with ARDS??
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Objective To evaluate the relation between MCP-1-2518G/A gene polymorphism and the onset risk of diabetic nephropathy(DN) by the data of collected and publishedcase control studies and using the meta analysis method .Methods All lit-eratures on moncyte chemoattractant protein-1(MCP-1)-2518G/A gene polymorphism and the onset risk of DN included in the da-tabases of PubMed ,Web of Science ,EMbase ,Cochrane Library ,CNKI ,Wanfang and VIP until October 2016 were systametically re-trieved .Then the related data were extracted .The Stata11 .0 statistical software was used to calculate the odds ratio (OR) of syn-thetic data and 95% confidence interval (CI) ,meanwhile the heterogeneity and publication bias of the studies were evaluated .Re-sults A total of 9 studies were included involving 2767 independent samples ,the number of cases was 1096 ,the control number was 1671 .For the general population ,the relationship between MCP-1 gene-2518G/A polymorphism and the onset risk of DN was not found in 4 gene models (dominant model:OR=1 .01 ,95% CI:0 .67-1 .54 ;recessive model :OR=0 .93 ,95% CI:0 .60-1 .44 ;homo-zygous model:OR=0 .93 ,95% CI:0 .70 -1 .23 ;heterozygous model :OR=0 .89 ,95% CI:0 .61-1 .31) .The subgroup analysis re-sults showed that in India population ,MCP-1-2518G/A gene polymorphism might significantly increase the onset risk of DN (domi-nant model:OR=1 .56 ,95% CI:1 .19 -2 .06) ,but in Chinese ,Turks or South Koreans ,the MCP-1-2518G/A gene polymorphism had no relation with the onset risk of DN .Conclusion In the general population ,MCP-1-2518G/A gene polymorphism has no rela-tion with the onset risk of DN .But the MCP-1 gene-2518G/A polymorphism can increase the onset risk of DN in India population , while does not increase the onset risk of DN in Chinese population ,Korean population and Turkey population .
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Objective To investigate the effect of aminophylline and pentoxyverine on serum CRP, monocyte chemotaxis protein 1(MCP-1) and serum immune factors in elderly patients with sleep apnea syndrome .Methods 112 elderly patients with apnea syndrome were divided into the control group and the experiment group by order of medical treatment and 56 cases in each group.The control group were treated by rosiglitazone hydrochloride tablets and bay three ramie snore capsule and the experiment group were treated on the control group with Aminophylline Tablets and Pentoxyverine Citrate Tablets.Follow up 3 months, the CRP, MCP-1,IFN-γ,IL-4,IL-8 and IL-10 were tested and compared.Results Compared with the control group after treatment, the CRP,MCP-1,IFN-γand IL-8 level were lower(P <0.05),the IL-4 and IL-10 level were higher(P <0.05).Conclusion Aminophylline and pentoxyverine can be effective in treatment of elderly patients with apnea syndrome and its complications , suggesting that the mechanism may be related to reduce the patients serum CRP, MCP-1, IL-8 and IFNγ-levels, is related to the increasing of the levels of IL-4, IL-10.