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1.
Rev. argent. reumatolg. (En línea) ; 33(2): 97-100, abr. - jun. 2022. ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1395244

ABSTRACT

La vasculitis reumatoidea es un proceso inflamatorio poco frecuente que confiere una morbilidad y mortalidad significativa en pacientes con artritis reumatoidea (AR). Presenta una incidencia de 0,7 a 5,4% de los casos de AR y hasta un 40% de mortalidad a 5 años, siendo la manifestación extraarticular de mayor gravedad1,2. Se caracteriza por el desarrollo de vasculitis necrotizante; ocurre típicamente en pacientes masculinos con AR seropositiva de larga data, nodular y erosiva, tabaquistas y, en general, tiene mal pronóstico. Se presenta una serie de casos, paciente masculino y femenino con AR y manifestaciones extraarticulares, necrosis digital y compromiso multiorgánico, interpretados como cuadros de vasculitis reumatoidea, realizando tratamiento de referencia con inmunosupresores.


Rheumatoid vasculitis is a rare inflammatory process that confers significant morbidity and mortality in patients with rheumatoid arthritis (RA); it has an incidence of 0.7 to 5.4% of RA cases and up to 40% mortality at five years, making it the most serious of all the extra-articular manifestations of RA1,2. It is characterized by the development of necrotizing vasculitis, it typically occurs in male patients with long-standing seropositive RA, erosive nodular, smokers and generally has a poor prognosis. A series of cases is presented, male and female with RA and extra-articular manifestations, digital necrosis and multiorgan system involvement, interpreted as rheumatoid vasculitis, undergoing treatment with immunosuppressants.


Subject(s)
Arthritis, Rheumatoid , Vasculitis , Immunosuppression Therapy , Mononeuropathies
2.
Chinese Journal of Medical Imaging Technology ; (12): 1281-1285, 2020.
Article in Chinese | WPRIM | ID: wpr-860899

ABSTRACT

Objective: To explore the value of quantitative analysis of gastrocnemius metabolites with 1H-MRS for early evaluation on diabetic peripheral neuropathy in diabetic rat models. Methods: Totally 40 male SD rats were randomly divided into experimental group and normal group (each n=20). In experimental group, diabetes models were established by feeding with high sugar and high-fat fed diet and streptozotocin injection. The right gastrocnemius 1H-MRS of 2 groups were collected before modeling as well as 7 days, 14 days and 21 days after modeling. The concentration values of choline-containing compounds (Cho), creatine compounds (Cr), intra-myocellular lipids (IMCL), Cho/Cr and IMCL/Cr were obtained. The rats in normal group were fed with general diet. Electrophysiological and pathological examinations were performed 21 days after modeling, the motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) of right sciatic nerve were measured. The metabolite concentration values at each time point in experimental group were compared, and MNCV and SNCV were compared between groups. The pathological results of 2 groups were observed. Results: There were differences of values of Cho, Cho/Cr, Cr, IMCI, IMCI/Cr in experimental group at different time points (F=6.69, 5.41, 3.65, 3.51, 3.10, all P<0.05). Cho and Cr values 14 days and 21 days after modeling were higher than those before modeling (both P<0.05), and IMCL values 7 days after modeling were higher than those before modeling (P<0.05). MNCV and SNCV of the right sciatic nerve in experimental group were slower than those in normal group 21 days after modeling (t=2.74, 4.62, both P<0.05). Compared with normal group, the nerve fibers in experimental group were sparse, loose and disordered, some myelin sheaths were stained lightly and unevenly and axons became thin and atrophic. Conclusion: 1H-MRS can be used for noninvasive quantitative analysis of skeletal metabolites, so as for early evaluation of DPN in rat diabetic models.

3.
Indian J Ophthalmol ; 2019 Jul; 67(7): 1133-1136
Article | IMSEAR | ID: sea-197356

ABSTRACT

Purpose: Our study aims at evaluating the efficacy and safety of botulinum toxin A in the early treatment of sixth nerve palsy in type 2 diabetic patients. Methods: This study is a prospective and interventional clinical case series of patients presenting with acute onset of sixth cranial nerve palsy, who received injection botulinum toxin A. Results: Thirty-one cases were included in the study. 58% of the study subjects had incomplete palsy at presentation (abduction deficit -1 to -3) and 42% had complete palsy (-4 and -5). The median dosage of injection was 5 U (range 3--6 U). The median follow-up period is 2 months. The P value shows that there is statistically significant improvement in head turn, ocular deviation in primary position, and improvement in abduction between baseline and 1 week (P-value <0.001), 1 month (P-value <0.001) and 2 month (P-value <0.001) postinjection follow-up visits. 90.3% of patients had full resolution of symptoms in the last follow-up visit. 83.9% of patients were successfully treated. Conclusion: Early injection of botulinum toxin A in select patients with acquired sixth nerve palsy due to diabetes is a safe and efficient treatment option in alleviating symptoms, restoring function and quality of life and reducing need for surgical interventions in future.

4.
The Medical Journal of Malaysia ; : 499-503, 2019.
Article in English | WPRIM | ID: wpr-825283

ABSTRACT

@#Introduction: Carpal tunnel syndrome (CTS) is the commonest median nerve entrapment neuropathy of the hand, up to 90% of all nerve compression syndromes. The disease is often treated with conservative measures or surgery. The senior author initially intended to treat his own neurosurgical patients concurrently diagnosed with carpal tunnel syndrome in 2014, subsequently, he began to pick up more referrals from the primary healthcare group over the years. This has led to the setup of a peripheral and spine clinic to act as a hub of referrals. Objective: Department of Neurosurgery Sarawak aimed to evaluate the surgical outcome of carpal tunnel release done over five years. Methods: The carpal tunnel surgeries were done under local anaesthesia (LA) given by neurosurgeons (Bupivacaine 0.5% or Lignocaine 2%). Monitored anaesthesia care (MAC) was later introduced by our hospital neuroanaesthetist in the beginning of 2018 (Target-controlled infusion propofol and boluses of fentanyl). We looked into our first 17 cases and compared these to the two anaesthesia techniques (LA versus MAC + LA) in terms of patient’s pain score based on visual analogue scale (VAS). Results: Result showed MAC provided excellent pain control during and immediately after the surgery. None experienced anaesthesia complications. There was no difference in pain control at post-operation one month. Both techniques had equal good clinical outcome during patients’ clinic follow up. Conclusion: Neurosurgeons provide alternative route for CTS patients to receive surgical treatment. Being a designated pain free hospital, anaesthetist collaboration in carpal tunnel surgery is an added value and improves patients overall experience and satisfaction.

5.
Rev. bras. neurol ; 54(3): 35-38, jul.-ago. 2018. graf
Article in English | LILACS | ID: biblio-948100

ABSTRACT

Statins are frequently prescribed in clinical practice for their proven efficacy in prevention of cardiovascular and cerebrovascular diseases. Despite the recognized beneficial effects of this class of drugs, in recent years, many studies published in medical literature have shown a wide range of adverse effects as a consequence of this therapy, including the risk of peripheral neuropathy. The purpose of this article is to report a case in which clinical features consistent with multiple mononeuropathy probably secondary to use of pravastatin were observed. The case report is followed by a review of the relevant literature.


As estatinas são frequentemente prescritas na prática clínica por sua comprovada eficácia na prevenção de doenças cardiovasculares e cérebrovasculares. Apesar dos reconhecidos efeitos benéficos dessa classe medicamentosa, nos últimos anos, diversos estudos publicados na literatura médica vem evidenciando uma ampla variedade de efeitos colaterais como consequência desta terapia, incluindo o risco de neuropatias periféricas. O objetivo deste artigo é relatar um caso no qual foram observadas manifestações clínicas compatíveis com o diagnóstico de mononeuropatia múltipla sensitiva, provavelmente secundária ao uso de pravastatina. O relato de caso é acompanhando de uma revisão de dados pertinentes da literatura.


Subject(s)
Humans , Male , Middle Aged , Pravastatin/adverse effects , Pravastatin/therapeutic use , Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects , Mononeuropathies/diagnosis , Mononeuropathies/chemically induced , Paresthesia/etiology , Review Literature as Topic , Hyperesthesia
6.
The Korean Journal of Pain ; : 215-220, 2018.
Article in English | WPRIM | ID: wpr-742185

ABSTRACT

Meralgia paresthetica (MP) is a sensory mononeuropathy, caused by compression of the lateral femoral cutaneous nerve (LFCN) of thigh. Patients refractory to conservative management are treated with various interventional procedures. We report the first use of extended duration (8 minutes) pulsed radiofrequency of the LFCN in a case series of five patients with refractory MP. Four patients had follow up for 1–2 years, and one had 6 months follow up. All patients reported remarkable and long lasting symptom relief and an increase in daily life activities. Three patients came off medications and two patients required minimal doses of neuropathic medications. No complications were observed.


Subject(s)
Humans , Analgesia , Catheter Ablation , Chronic Pain , Follow-Up Studies , Mononeuropathies , Neuralgia , Pain Management , Pulsed Radiofrequency Treatment , Thigh
7.
Journal of Clinical Neurology ; : 274-281, 2016.
Article in English | WPRIM | ID: wpr-138777

ABSTRACT

Neurolymphomatosis (NL) defined as infiltration of the central nervous system or the peripheral nervous system (PNS) by malignant lymphoma cells is a rare clinical entity. However, the increasing use of fluorodeoxyglucose positron-emission tomography (FDG-PET) and magnetic resonance imaging in evaluating PNS disorders is resulting in; this condition being recognized more frequently. Here; we report five NL patients and review the current literature. We report five patients with non-Hodgkin's lymphoma (NHL) and NL, all of whom were men aged 47-69 years. The clinical presentation varied from symmetrical peripheral neuropathy to mononeuropathy. Peripheral neuropathy was the presenting manifestation of a systemic lymphoma in two patients (40%). Neuroimaging as well as whole-body FDG-PET helped in determining the correct diagnosis in all of the patients. NL is an unusual presentation of NHL resulting from infiltration of the PNS by malignant lymphomatous cells. While evaluating peripheral neuropathy, a high degree of suspicion of NL is required since the presenting symptoms vary, conventional radiology has only modest sensitivity, and a pathological diagnosis is often difficult. FDG-PET helps in the early diagnosis and treatment of this condition.


Subject(s)
Animals , Humans , Male , Central Nervous System , Diagnosis , Early Diagnosis , Lymphoma , Lymphoma, Non-Hodgkin , Magnetic Resonance Imaging , Marek Disease , Mononeuropathies , Neuroimaging , Peripheral Nervous System , Peripheral Nervous System Diseases , Positron-Emission Tomography
8.
Journal of Clinical Neurology ; : 274-281, 2016.
Article in English | WPRIM | ID: wpr-138776

ABSTRACT

Neurolymphomatosis (NL) defined as infiltration of the central nervous system or the peripheral nervous system (PNS) by malignant lymphoma cells is a rare clinical entity. However, the increasing use of fluorodeoxyglucose positron-emission tomography (FDG-PET) and magnetic resonance imaging in evaluating PNS disorders is resulting in; this condition being recognized more frequently. Here; we report five NL patients and review the current literature. We report five patients with non-Hodgkin's lymphoma (NHL) and NL, all of whom were men aged 47-69 years. The clinical presentation varied from symmetrical peripheral neuropathy to mononeuropathy. Peripheral neuropathy was the presenting manifestation of a systemic lymphoma in two patients (40%). Neuroimaging as well as whole-body FDG-PET helped in determining the correct diagnosis in all of the patients. NL is an unusual presentation of NHL resulting from infiltration of the PNS by malignant lymphomatous cells. While evaluating peripheral neuropathy, a high degree of suspicion of NL is required since the presenting symptoms vary, conventional radiology has only modest sensitivity, and a pathological diagnosis is often difficult. FDG-PET helps in the early diagnosis and treatment of this condition.


Subject(s)
Animals , Humans , Male , Central Nervous System , Diagnosis , Early Diagnosis , Lymphoma , Lymphoma, Non-Hodgkin , Magnetic Resonance Imaging , Marek Disease , Mononeuropathies , Neuroimaging , Peripheral Nervous System , Peripheral Nervous System Diseases , Positron-Emission Tomography
9.
General Medicine ; : 99-102, 2015.
Article in English | WPRIM | ID: wpr-377070

ABSTRACT

Eosinophillic glanuromatosis with polyangitis (EGPA) usually occurs in patients with a recent history (usually less than 10 years) of uncontrolled bronchial asthma. Here we describe a case of EGPA that occurred in a 68-year-old female who had well-controlled bronchial asthma for 17 years. A leukotriene receptor antagonist that had been prescribed one week before onset might have triggered the disease. Our case shows that there is a wide spectrum of clinical characteristics of EGPA, making diagnosis difficult in a primary care setting.

10.
Indian J Ophthalmol ; 2014 Oct ; 62 (10): 10008-1012
Article in English | IMSEAR | ID: sea-155778

ABSTRACT

Aims: The aim was to assess the etiology of sixth nerve palsy and on the basis of our data, to formulate a diagnostic algorithm for the management in sixth nerve palsy. Design: Retrospective chart review. Results: Of the 104 neurologically isolated cases, 9 cases were attributable to trauma, and 95 (86.36%) cases were classified as nontraumatic, neurologically isolated cases. Of the 95 nontraumatic, isolated cases of sixth nerve palsy, 52 cases were associated with vasculopathic risk factors, namely diabetes and hypertension and were classified as vasculopathic sixth nerve palsy (54.7%), and those with a history of sixth nerve palsy from birth (6 cases) were classified as congenital sixth nerve palsy (6.3%). Of the rest, neuroimaging alone yielded a cause in 18 of the 37 cases (48.64%). Of the other 19 cases where neuroimaging did not yield a cause, 6 cases were attributed to preceding history of infection (3 upper respiratory tract infection and 3 viral illnesses), 2 cases of sixth nerve palsy were found to be a false localizing sign in idiopathic intracranial hypertension and in 11 cases, the cause was undetermined. In these idiopathic cases of isolated sixth nerve palsy, neuroimaging yielded no positive findings. Conclusions: In the absence of risk factors, a suggestive history, or positive laboratory and clinical findings, neuroimaging can serve as a useful diagnostic tool in identifying the exact cause of sixth nerve palsy. Furthermore, we recommend an algorithm to assess the need for neuroimaging in sixth nerve palsy.

11.
Chinese Journal of Internal Medicine ; (12): 384-389, 2014.
Article in Chinese | WPRIM | ID: wpr-447006

ABSTRACT

Objective To summarize the clinical features,electrophysiology and neuropathological characteristics of peripheral nerves in patients with vasculitic neuropathy.Methods We retrospectively analyzed the clinical,electrophysiology and neuropathological characteristics of 15 patients with vasculitic neuropathy who underwent electrophysiology and sural nerve biopsy in our department from January 2009 to June 2013.Results There were 8 males and 7 females,aged from 38 to 82 years old,with a peripheral neuropathy course ranged from 0.5 month to 60 months.In the total of 15 patients,3 patients were diagnosed as nonsystemic vasculitic neuropathy,while the other 12 patients were diagnosed as systemic vasculitis neuropathy (SVN) including 5 cases of primary systemic vasculitis and 7 cases of secondary systemic vasculitis.In patients diagnosed as primary systemic vasculitis,there were 2 cases of Churg-Strass syndrome (CSS) and 3 cases of ANCA associated vasculitis.In patients diagnosed as secondary systemic vasculitis,there were 1 case of systemic lupus erythematosus (SLE),2 cases of sicca syndrome (SS),3 cases of rheumatoid arthritis (RA),1 case of Behcet' s disease associated with thyroid papillary carcinoma,1 case of hepatitis B and 1 case of RA-associated SS.For the pathological features of vasculitic neuropathy,type 1 lesion was found in 4 patients,type 2 lesion in 2 patients,and type 3 lesion in 9 patients.Axon degeneration was observed in 8 patients,while 7 patients manifested as axon degeneration associated with demyelination and local thickening of the perineurium was found in 2 patients.Conclusion Multiple mononeuropathy and asymmetric polyneuropathy are the common clinical presentations of vasculitic neuropathy.Electrodiagnostic testing almost always reveals the evidence of a predominantly axonal and sensorimotor process with associated demyelination presented in some cases.Sural nerve biopsy showes changes indicative of an axonopathy.

12.
Rev. cuba. pediatr ; 85(2): 252-257, abr.-jun. 2013.
Article in Spanish | LILACS | ID: lil-678137

ABSTRACT

La parálisis aislada del tercer par craneal no es frecuente en los niños. Entre las causas que la originan se encuentran las congénitas, traumáticas, infecciosas, tumorales, vasculares, tóxicas y desmielinizantes. Se presenta un paciente de 3 años de edad con el diagnóstico de una oftalmoplejía aguda dolorosa del tercer par craneal, cuya etiología no se pudo demostrar. El cuadro clínico desapareció de forma espontánea y no ha presentado recurrencias después de 3 años de seguimiento. Se concluye que ante un paciente con parálisis del tercer par craneal es necesario realizar una exhaustiva evaluación con el propósito de precisar las diversas causas que la provocan


Isolated third cranial nerve palsy is not frequent in children. Among the causes are congenital, traumatic, infectious, tumoral, vascular, toxic and demyelinizing. This is the case of a 3-years old patient diagnosed with acute painful ophthalmoplegia of the third cranial nerve, in which etiology could not be proved. The clinical picture disappeared spontaneously and no recurrence has emerged after 3 years of follow-up. It was concluded that when dealing with a patient with third cranial nerve palsy, it is necessary to make a thorough assessment to precise over the different causes


Subject(s)
Humans , Male , Oculomotor Nerve Diseases/diagnosis , Oculomotor Nerve Diseases/etiology , Ophthalmoplegia/diagnosis
13.
Rev. argent. neurocir ; 24(2): 67-70, abr.-jun. 2010. ilus
Article in Spanish | LILACS | ID: lil-607098

ABSTRACT

Objetivo: presentar un caso de mononeuropatía hipertrófica localizada. Descripción: paciente de 39 años de edad, que presenta una historia de dolor intenso y progresivo, hipoestesia en la región tenar y déficit motor en la mano izquierda. El examen físico mostró atrofia hipotener, mano en garra cubital y signo de Tinel en el antebrazo (8cm distal a la epitróclea). Intervención: la IRM mostró una masa a lo largo del recorrido del nervio cubital en el antebrazo. Se sugirió entonces tratamiento quirúrgico. No se obtuvo registro de conducción nerviosa durante la estimulación intraoperatoria, por lo cual se resecó la zona de fascículos afectados y se reemplazó la lesión por injertos autólogos extraídos de nervio sural. El diagnóstico histopatológico fue dificultoso y después de varias revisiones se concluyó que se trataba de de una mononeuropatía hipertrófica localizada. Conclusión: la paciente se encuentra actualmente bajo seguimiento y está mostrando signos de mejoría de la anestesía junto a remisión completa del dolor.


The authors report the case of a 39 year-old female, who presented with 10 years history of intense progressive pain, hypoesthesia in hypotenar region and motor deficit in the left hand. The physical exam showed hypotenar muscles atrophy, "claw hand", and Tinel’s sign in the forearm (8 cm distal from the medial epicondyle). Magnetic resonance imaging showed a mass lesion along ulnar nerve path in the forearm. Surgical treatment was, then, suggested. Nerve conduction could not be registered during intra-operative stimulation. Microsurgical resection of the damaged nerve fascicles and sural nerve grafting were performed. Histopathological diagnosis was difficult and could only be confirmed as localized hypertrophic mononeuropathy after revision of the biopsied material. The patient is being followed up and she is showing signs of hypoesthesia improvement in addition to complete remission of the pain.


Subject(s)
Mononeuropathies , Ulnar Nerve
14.
Journal of Clinical Neurology ; : 156-158, 2010.
Article in English | WPRIM | ID: wpr-207092

ABSTRACT

BACKGROUND: Mononeuropathy multiplex is a rare complication during the course of chronic he-patitis B, despite various neuropathies following acute hepatitis B having been reported previously. CASE REPORT: A 30-year-old man presented with sensorimotor symptoms in multiple peripheral nerves. The serological tests for hepatitis were consistent with chronic active hepatitis B. After treatment with oral prednisone combined with an antiviral agent, the sensory and motor symptoms improved and hepatitis B virus replication was reduced. CONCLUSIONS: We suggest that chronic immune-mediated neuropathy associated with hepatitis B virus infection should be considered in the differential diagnosis of patients with hepatitis B.


Subject(s)
Adult , Humans , Diagnosis, Differential , Hepatitis , Hepatitis B , Hepatitis B virus , Hepatitis B, Chronic , Hepatitis, Chronic , Mononeuropathies , Peripheral Nerves , Prednisone , Serologic Tests
15.
Journal of the Korean Neurological Association ; : 194-198, 2007.
Article in Korean | WPRIM | ID: wpr-115388

ABSTRACT

BACKGROUND: It is important to consider leprosy as a cause of peripheral neuropathy, as it is readily treatable. We analyzed clinical and electrodiagnostic characteristics of leprosy patients with peripheral nerve involvement. METHODS: This study was a retrospective analysis of nerve conduction studies (NCS) and the medical records of 10 patients with leprosy were confirmed by a skin or nerve biopsy. NCS using a conventional surface technique were performed in 15 upper extremities and 14 lower extremities. RESULTS: Among ten patients, three patients presented with mononeuropathy, and the others with mononeuropathy multiplex. Five patients had medical histories of leprosy treatment. The patterns of peripheral neuropathies were mononeuropathy multiplex except for one who had an ulnar mononeuropathy. On motor NCS, low or absent CMAPs were most common abnormalities followed by slow conduction velocity and prolonged terminal latency. Sensory NCS also showed changes of amplitudes rather than in conduction velocity. The conduction block of CMAPs with or without dispersion were observed in 5 patients usually on the ulnar nerve at the forearm. CONCLUSIONS: In most instances, leprous patients with neuropathy presented with mononeuropathy multiplex affecting the sensory and motor nerves. NCS showed more likely axonal than demyelinating changes, but the conduction blocks were also found frequently at the forearms.


Subject(s)
Humans , Axons , Biopsy , Forearm , Leprosy , Lower Extremity , Medical Records , Mononeuropathies , Neural Conduction , Peripheral Nerves , Peripheral Nervous System Diseases , Retrospective Studies , Skin , Ulnar Nerve , Upper Extremity
16.
Yonsei Medical Journal ; : 891-893, 2007.
Article in English | WPRIM | ID: wpr-179436

ABSTRACT

Femoral mononeuropathy (FMN) as an extraarticular finding of rheumatoid arthritis (RA) is a phenomenon which has not been reported previously. We report a 53-year-old female patient with RA, presenting FMN findings during the course of the disease. On examination, right quadriceps and iliopsoas muscles showed grade 3 weakness on the Medical Research Council (MRC) scale. Sensory examination revealed sensory loss in the right medial leg and thigh. Patellar tendon reflex was absent in the right side. A diagnosis of a partial right femoral neuropathy was confirmed using nerve conduction study and electromyography. The probable mechanism of FMN was thought to be vasculitis.


Subject(s)
Female , Humans , Middle Aged , Arthritis, Rheumatoid/complications , Electromyography , Femoral Neuropathy/complications , Hand/diagnostic imaging , Neural Conduction
17.
Journal of the Korean Neurological Association ; : 455-461, 2007.
Article in Korean | WPRIM | ID: wpr-158641

ABSTRACT

BACKGROUND: Based on a recent study showing that the reactivation of HSV-1 may be one of the possible pathogenesis of idiopathic facial mononeuropathy, antiviral therapy has been suggested as a good treatment modality. However, the efficacy of antiviral therapy is still controversial. This argument may be caused by the absence of a reliable system of grading facial nerve paralysis. We performed this study to investigate the therapeutic effects of an antiviral agent and possible prognostic factors using the Sunnybrook scale. METHODS: Patients with idiopathic facial mononeuropathy were divided as two groups according to the treatment regimens (Acyclovir & Steroid vs. Steroid only). Clinical efficacy was evaluated using the House-Brackmann grading system and Sunnybrook scale. Electrodiagnostic studies including the blink reflex, facial nerve conduction study, and facial nerve excitability test were performed. The clinical improvement rate between the two groups and the usefulness of the electrodiagnostic studies as prognostic factors were analyzed. RESULTS: No significant differences of the clinical improvement rate was revealed with a 70% improvement rate for the Acyclovir treatment group and 84% for the steroid only group. Among electrodiagnostic studies, the compound muscle gamma action potential (CMAP) amplitude (=0.637, p=0.000) and nerve excitability =0.688, gamma test (p=0.000) on 2 weeks showed significant correlations to the final Sunnybrook score. There is good correlation between the two facial nerve grading systems. CONCLUSIONS: Acyclovir may not be effective in the recovery of idiopathic facial mononeuropathy. CMAP amplitude and nerve excitability tests on 2 weeks may provide valuable prognostic factors. The Sunnybrook scale may be useful as a facial grading system.


Subject(s)
Humans , Action Potentials , Acyclovir , Blinking , Facial Nerve , Herpesvirus 1, Human , Mononeuropathies , Paralysis
18.
Journal of the Korean Academy of Rehabilitation Medicine ; : 346-352, 2006.
Article in Korean | WPRIM | ID: wpr-724169

ABSTRACT

OBJECTIVE: The purpose of this study was to determine the natural history of symptomatic hands without electrodiagnostic evidence of carpal tunnel syndrome (CTS). METHOD: This study was comprised of 88 hands of 49 subjects with symptoms consistent with CTS without median mononeuropathy who were recruited during a community health examination and followed after two years. 88 hands of 44 people with age and sex-matched healthy controls were followed for comparison. Symptoms and electrodiagnostic findings were compared between the two groups. RESULTS: 62 hands of the symptomatic group had persistent symptoms after 2 years while 16 hands of the control group had symptoms consistent with CTS. Median motor distal latencies were significantly delayed after two years in the symptomatic group (p<0.05). Median sensory latencies were also delayed in the symptomatic group, but this was not statistically significant (p=0.064). The occurrence rate of median mononeuropathy at wrist was significantly higher in the symptomatic group than in the control group (13.6% vs. 2.3%)(p<0.05). CONCLUSION: The results of this study suggested that a significant number of symptomatic hands without electrodiagnostic evidence of CTS may have persistent symptoms and may progress to electrodiagnostically evident CTS.


Subject(s)
Carpal Tunnel Syndrome , Follow-Up Studies , Hand , Mononeuropathies , Natural History , Wrist
19.
Journal of the Korean Neurological Association ; : 601-604, 2006.
Article in Korean | WPRIM | ID: wpr-23265

ABSTRACT

Neurolymphomatosis, which is defined as a peripheral nerve infiltration of lymphoma, is an infrequent complication of systemic lymphoma and the isolated involvement of the peripheral nerve as a sign of recurrence is very rare. Here, we report a case with neurolymphomatosis presented as a mononeuropathy multiplex and is the first reported case in Korea. With potent chemotherapy, the blood-nerve barrier may have a critical role in the isolated recurrence of lymphoma in the peripheral nervous system.


Subject(s)
Animals , Blood-Nerve Barrier , Drug Therapy , Korea , Lymphoma , Lymphoma, B-Cell , Marek Disease , Mononeuropathies , Peripheral Nerves , Peripheral Nervous System , Recurrence
20.
Journal of the Korean Academy of Rehabilitation Medicine ; : 383-386, 2005.
Article in Korean | WPRIM | ID: wpr-722441

ABSTRACT

OBJECTIVE: An electromyographic examination is often utilized to confirm the diagnosis of suprascapular neuropathy in patients with shoulder pain and dysfunction. The purpose of this study was to compare two recording methods (surface and monopolar needle electrode recordings) for the evaluation of suprascapular nerve. METHOD: Twenty-two healthy subjects were tested with each method. Differences between the recording methods were compared for compound muscle action potential (CMAP) latencies and amplitudes. And the parameters obtained from two recording methods were correlated. RESULTS: The mean age was 43.6+/-12.4 years (range: from 23 to 72 years old). The surface recordings appeared to give a more reproducible latency and amplitude of CMAP of the infraspinatus. The surface recorded CMAP latency and amplitude were 2.58+/-0.46 ms, and 12.6+/-2.7 mV, respectively. Those of the needle electrode recording were 2.49+/-0.41 ms and 27.6+/-6.55 mV, respectively. The two recordings were significantly correlated in latency (r=0.876, p<0.05) and amplitude(r=0.484, p<0.05). CONCLUSION: Considering the invasiveness of study and compliance of the patient, the surface electrode recording may be prudent for the convenient assessment and follow up studies in suprascapular nerve conduction study.


Subject(s)
Humans , Action Potentials , Compliance , Diagnosis , Electrodes , Mononeuropathies , Needles , Neural Conduction , Shoulder Pain
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