Clinical Profile and Predictors of In-Hospital Mortality in Septic Shock Patients in a Tertiary Care Hospital.

strong>Background: Sepsis and Septic shock contributes to significant morbidity and mortality in hospitalized patients. Early detection and initiation of early and appropriate antibiotic therapy determines the outcome in septic shock. The objective of this research was to describe clinical profile of septic shock patients and to determine various predictors of in-hospital mortality in septic shock patients which could be assessed from simple hematological parameters. Methods: This was a prospective observational study done over a period of one year in which a total of 145 adult patients with septic shock diagnosed as per American College of Chest Physicians (ACCP) and the Society for Critical Care Medicine (SCCM) criteria (2016) admitted in medicine ward in a tertiary care hospital were included. Detailed history and clinical examination was done and various routine investigations such as Complete hemogram, Neutrophil to lymphocyte ratio(NLR), Platelet to lymphocyte ratio(PLR), Liver function tests, Renal function tests, C-reactive protein and Blood gases including lactate levels at admission were determined and compared among survivors and non-survivors to assess in hospital mortality predictors. Results: A total of 145 patients with septic shock were studied. Most of the patients were males (55.2%). Majority were from rural areas (59.31%). Major co-morbidities included diabetes mellitus (24.8%), COPD (13.1%) and hypertension (11%). Fever was the most common presentation (34.5%). Mortality in septic shock was 30.3%. The most common source of infection leading to septic shock was scrub typhus (33.8%) followed by respiratory infections and skin infections. The highest mortality was seen in the age group of 60-69 years. Patients who were given primary care and stabilized in a primary or secondary health centre and then referred had a better survival (77.2%) as compared to those who directly visited the tertiary care centre in a sick state. Out of various mortality predictors studied, a strong positive correlation of mortality was seen among patients with thrombocytopenia i.e. platelet count (86.4%), hypoalbuminemia (78.6%), high neutrophil to lymphocyte ratio, high C-reactive protein values(74%) and high mean platelet volume. Conclusion: There is high prevalence of tropical infections such as Scrub typhus in Himachal and even simple investigations like Complete haemogram, Serum albumin levels, C-reactive protein and Total serum bilirubin levels which are routinely done in health care centers correlate significantly with mortality in septic shock. These investigations can guide appropriate antibiotic therapy and appropriate timing of referral of patients to higher centers, hence can improve the outcome among septic shock patients.

Early hematological parameters as predictors for outcomes in children with dengue in northern India: A retrospective analysis

Abstract INTRODUCTION: Dengue presents with a variable clinical course, ranging from mild illness to potentially fatal hemorrhage and shock. We aimed to evaluate the capabilities of various hematological parameters observed early in the course of illness for predicting the clinical outcomes of illness. METHODS: We retrospectively analyzed the records of children admitted in the pediatric inpatient services of the institute with dengue between 2017 and 2019. We determined the relationships between the hematological parameters observed during the first evaluation and the various clinical outcomes. RESULTS: We evaluated data from 613 patients (age range, 26 days to 17 years). Of these, 29.85% exhibited fever with warning signs, and 8.97% had severe dengue. Lower values of hemoglobin, platelet count, mean corpuscular volume, mean corpuscular hemoglobin concentration, and mean platelet volume, and higher values of total leukocyte count (TLC), hematocrit, and red cell distribution width variably correlated with numerous clinical outcomes-duration of hospital stay, development of complications, requirement of blood component transfusion, inotropic support, and mortality. Among the parameters, TLC ≥20,000/mL and initial platelet count ≤20,000/mL significantly associated with mortality, with odds ratios (95% confidence interval) of 11.81 (4.21-33.80) and 5.53 (1.90-16.09), respectively. CONCLUSIONS: Hematological parameters observed early during dengue infection may predict its clinical outcomes in infected children. Initial high TLC and low platelet count are potential predictors of fatal outcomes in the course of disease.

Thrombocytopenia in children 2 months to 12 years of age admitted in the paediatric intensive care unit of a tertiary care hospital

Background: To assess the etiology, clinical profile, complications, outcome and prognosis of children admitted in the paediatric ICU with thrombocytopeniaMethods: This study was done on children admitted to the paediatric ICU of Tirunelveli Medical College Hospital during the period from December 2011 to April 2012. 112 consecutive' patients aged' 2 months to 12 years with platelet counts less than 1 lakh were studied.Results: One in 6.25 children admitted in the paediatric ICU developed thrombocytopenia(15.95%incidence).The commonest age group of presentation of is 6-10 years(47.3%).Infants(45.5%) died more. Dengue(58.8%) was the commonest etiology, followed by enteric fever(11.6%), acute lymphoblastic leukemia (all 4.5%), septicemia(4.5%), plasmodium vivax malaria (2.7%). Leading cause of mortality is dengue shock syndrome(DSS' 44.4%). The most common presenting symptom among the study group is fever(95.5%). Abdominal distension and pedal edema were significantly associated with low platelet counts, bleeding manifestations, increased transfusion needs and a' poor outcome. The presence of Altered sensorium, tachycardia, tachypnea, shock, seizures at presentation were all associated with significant bleeding and high mortality. Gastrointestinal bleed(41.07%) was the commonest bleeding manifestation. There was no significant correlation between the exact platelet counts and the bleeding. Children with counts less than 10,000' had a poor outcome.(57.1% mortality). Gall bladder wall edema and pleural effusion in Ultrasound correlate significantly with bleeding.Conclusions:' Thrombocytopenia is common in sick children in' paediatric ICU and has a definite bearing on prognosis. Infants have poor prognosis and need intensive monitoring. Mortality predictors, if present, need aggressive management. There is no role for prophylactic transfusions, as platelet counts do not correlate with bleeding.

Insuficiencia aórtica aguda por endocarditis infecciosa / Acute aortic regurgitation due to infective endocarditis

La insuficiencia aórtica aguda (IAOA) por endocarditis infecciosa (EI) es grave y generalmente requiere tratamiento quirúrgico. Se compararon los pacientes con IAOA grave por EI e insuficiencia cardíaca (IC) en clase funcional I-II NYHA (G1) con los pacientes en clase funcional III-IV (G2) en relación a características clínicas, ecocardiográficas, microbiológicas y evolución hospitalaria y se evaluaron los predictores de mortalidad, en un centro de alta complejidad. Desde 06/92 a 07/16, de 439 pacientes con EI, 86 presentaron IAOA: (G1, 39: 45.4% y G2, 47: 54.7%). El G1 presentó mayor EI protésica (43.6% vs. 17.0%; p < 0.01). Los 47 casos G2 presentaban disnea vs. 12 (30.8%) G1 (p < 0.0001). No hubo diferencias en cuanto a las características clínicas, ecocardiográficas y microbiológicas. El tratamiento quirúrgico fue principalmente por extensión de la infección y/disfunción valvular en el G1 y por IC en el G2. La mortalidad hospitalaria fue del 15.4% vs. 27.7% (G1 y G2 respectivamente, p NS). Fueron predictores en el análisis multivariado: la infección intrahospitalaria (p 0.001), los hemocultivos negativos (p 0.004) y la presencia de IC clase funcional III-IV (p 0.039).Una quinta parte de los pacientes con EI presentaron IAOA. Aquellos con IC grave requirieron tratamiento quirúrgico de emergencia y con IC con clase funcional I-II requirieron cirugía por extensión de la infección y/o disfunción valvular. La mortalidad quirúrgica y hospitalaria continúan siendo elevadas en ambos grupos y fueron predictores de mortalidad hospitalaria: la infección intrahospitalaria, los hemocultivos negativos y la IC avanzada.

Acute aortic regurgitation (AAR) due to infective endocarditis (IE) is a serious disease and usually requires surgical treatment. Our study aims to compare the clinical, echocardiographic, and microbiological characteristics as well as in-hospital outcome of patients with AAR according to the severity of heart failure (HF) and to evaluate predictors of in-hospital mortality in a tertiary centre. In a prospective analysis, we compared patients with NYHA functional class I-II HF (G1) vs. functional class III-IV HF (G2). From 06/92 to 07/16, 439 patients with IE were hospitalized; 86 presented AAR: (G1, 39: 45.4% y G2, 47: 54.7%). The G1 had higher prosthetic IE (43.6% vs. 17%, p 0.01). All G2 patients had dyspnoea vs. 30.8% of the G1 (p < 0.0001). There were no differences in clinical, echocardiographic and microbiological characteristics. Surgical treatment was indicated mainly due to infection extension or valvular dysfunction in G1 and HF in G2. In-hospital mortality was 15.4% vs. 27.7% (G1 and G2 respectively p NS). In multivariate analysis, health care-associated acquisition (p 0.001), negative blood cultures (p 0.004), and functional class III-IV HF (p 0.039) were in-hospital mortality predictors. One-fifth of the patients with EI had AAR. Half of them had severe HF which needed emergency surgery and the remaining needed surgery for extension of the infection and / or valvular dysfunction. Both groups remain to have high surgical and in-hospital mortality. Health care-associated acquisition, negative blood cultures and advanced HF were predictors of in-hospital mortality.

Analysis of Shahid Rajaee hospital administrative data on injuries resulting from car accidents in Shiraz, Iran: 2011-2014 data / 中华创伤杂志(英文版)

<p><b>PURPOSE</b>The administrative data from trauma centers could serve as potential sources of invaluable information while studying epidemiologic features of car accidents. In this cross-sectional analysis of Shahid Rajaee hospital administrative data, we aimed to evaluate patients injured in car accidents in terms of age, gender, injury severity, injured body regions and hospitalization outcome in the recent four years (2011-2014).</p><p><b>METHODS</b>The hospital registry was accessed at Shiraz Trauma Research Center (Shiraz, Iran) and the admission's unit data were merged with the information gathered upon discharge. A total number of 27,222 car accident patients aged over 15 years with International Classification of Diseases 10th revision (ICD-10) external causes of injury codes (V40.9-V49.9) were analyzed. Injury severity score and injured body regions were determined based on converting ICD-10 injury codes to Abbreviated Injury Scale (AIS-98) severity codes using a domestically developed electronic algorithm. A binary logistic regression model was applied to the data to examine the contribution of all independent variables to in-hospital mortality.</p><p><b>RESULTS</b>Men accounted for 68.9% of the injuries and the male to female ratio was 2.2:1. The age of the studied population was (34 ± 15) years, with more than 77.2% of the population located in the 15-45 years old age group. Head and neck was the most commonly injured body region (39.0%) followed by extremities (27.2%). Injury severity score (ISS) was calculated for 13,152 (48.3%) patients, of whom, 80.9% had severity scores less than 9. There were 332 patients (1.2%) admitted to the intensive care units and 422 in-hospital fatalities (1.5%) were recorded during the study period. Age above 65 years [OR = 7.4, 95% CI (5.0-10.9)], ISS above 16 [OR = 9.1, 95% CI (5.5-14.9)], sustaining a thoracic injury [OR = 7.4, 95% CI (4.6-11.9)] and head injury [OR = 4.9, 95% CI (3.1-7.6)] were the most important independent predictors of death following car accidents.</p><p><b>CONCLUSION</b>Hospital administrative databases of this hospital could be used as reliable sources of information in providing epidemiologic reports of car accidents in terms of severity and outcomes. Improving the quality of recordings at hospital databases is an important initial step towards more comprehensive injury surveillance in Fars, Iran.</p>

Factores predictores de mortalidad en la sustitución valvular aórtica / Mortality predictors in the valvar aortic replacement

Se efectuó un estudio observacional y analítico de casos y controles en el Servicio de Cirugía Cardiovascular del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de Santiago de Cuba, del 2001 al 2010, en los 248 pacientes a quienes se les realizó sustitución valvular aórtica, con empleo tanto de prótesis mecánica como biológica, de los cuales se tomaron como muestra los 30 fallecidos durante dicha etapa (grupo de casos) y 60 intervenidos seleccionados de forma aleatoria (grupo de controles). Pudo observarse un predominio de la estenosis aórtica, el sexo masculino y las edades avanzadas. En la serie la mortalidad resultó de 12,1 % y como factores predictores de esta, mediante el análisis por regresión logística, fueron identificados: las cifras de creatinina elevadas en el período preoperatorio, el tiempo prolongado de derivación cardiopulmonar, la protección miocárdica no óptima, la recuperación cardíaca no espontánea y las complicaciones neurológicas.

An observational and analytic case-control study was carried out in the Cardiovascular Surgery Department of "Saturnino Lora Torres" Provincial Teaching Clinical-Surgical Hospital in Santiago de Cuba, from 2001 to 2010, in the 248 patients to whom an aortic valvar replacement was carried out, with the use of both mechanical and biological prosthesis, of which the 30 deaths during this stage (cases group) and 60 surgically treated selected at random (controls group) were taken as samples. A prevalence of aortic stenosis, the male sex and the advanced ages could be observed. In the series mortality was 12.1% and as predictors of it, by means of the logistical regression analysis, there were: the levels of high creatinine in the preoperative period, the long time of cardiopulmonary bypass, non optimal myocardial protection, non spontaneous heart recovery and the neurological complications.

Predictores de mortalidad hospitalaria en la hemorragia digestiva alta variceal por hepatopatía crónica tratada endoscópicamente / Predictors of intrahospitalary mortality in the upper gastrointestinal variceal bleeding due to chronic liver disease treated endoscopically

La hemorragia digestiva alta variceal es una de las complicaciones más graves en la hepatopatía crónica. El objetivo de este trabajo es identificar variables que predicen mortalidad hospitalaria. Material y métodos: 106 internaciones por esta patología desde octubre de 2001 hasta abril de 2006 en diseño de cohortes. Se confrontó mortalidad hospitalaria con edad, sexo, etiología de la hepatopatía, score APACHE II al ingreso, imensión de las várices evaluada endoscópicamente, severidad de la insuficiencia hepática evaluada por clases de Child Pugh, antecedente de hemorragia variceal, fracaso de la terapia endoscópica inicial, fracaso hemostático en las primeras 48hs y resangrado posterior a 48hs. Para identificar predictores independientes de mortalidad se seleccionaron todas las variables que correlacionaron significativamente con muerte hospitalaria. Para la variable cuantitativa score APACHE II de ingreso se consideró el valor que mejor discriminó mortalidad. Resultados: los predictores independientes de muerte hospitalaria fueron: el fracaso de la terapia endoscópica inicial (p=0,005), el fracaso hemostático en las primeras 48hs (p=0,012) y la clase C de Child Pugh (p=0,024). Si bien en el sexo masculino el score APACHE II al ingreso y el resangrado con posterioridad a las 48hs también correlacionaron con mortalimortalidad, no calificaron como predictores independientes. Conclusión: en portadores de hepatopatía crónica con hemorragia digestiva alta variceal y primera línea de tratamiento endoscópico, resultaron predictores independientes de muerte hospitalaria: 1) el fracaso de la terapia endoscópica hemostática inicial, 2) el fracaso hemostático en las primeras 48hs, y 3) la clase C de Child Pugh al ingreso.

Upper gastrointestinal variceal bleeding is one of the most serious complications in patients with chronic liver disease. The aim of this trial is to identify in hospital mortality predictors in this illness. Material and methods: 106 hospitalizations due to this disease from October 2001 to April 2006 in cohort design. In hospital mortality was confronted with age, sex, liver disease etiology, Apache II score at admission, variceal severity, severity of the hepatic failure evaluated according to the Child Pugh’s classes, a history of variceal bleeding, initial endoscopic treatment failure, haemostatic failure within the first 48 hours, and rebleeding after 48 hours from admission. In order to identify independent mortality predictors, all the variables correlated significantly with hospital mortality were selected. For the quantitative variable APACHE II score at admission, the best mortality discrimination value was chosen. Results: independent in hospital mortality predictors were: initial endoscopic treatment failure (p = 0,005), haemostatic failure in the first 48 hours (p = 0,012), and Child Pugh C class (p = 0,024). Although male sex, Apache II score at admission and rebleeding after 48 hours were also significantly related to mortality by univaried model, they did not qualify as independent predictors. Conclusions: the independent predictors of intrahospitalary mortality in patients with variceal bleeding due to chronic liver disease, and firstline of endoscopic treatment were: 1) Initial haemostatic endoscopic treatment failure, 2) Haemostatic failure in the first 48hs, and 3) Child Pugh C class hepatic failure at admission.