ABSTRACT
Objective: A single-center retrospective analysis was performed to obtain data on the clinical characteristics and the factors influencing the survival of patients with mucosa associated lymphoma tissue lymphoma (MALT lymphoma). Method: From September 2012 to May 2019, we retrospectively analyzed 180 cases of MALT lymphoma diagnosed through pathological biopsy. Result: Among the 180 patients, 99 (55.0%) were male and 81 (45.0%) were female. The age at onset was 31-84 years, and the median age was 57 years. There were 59 (32.8%), 66 (96.1%), and 55 (3.9%) cases involving gastrointestinal, ocular, and other extranodal primary sites, which included the lung, pharyngeal lymph ring, thyroid, parotid gland, and testis, respectively. Moreover, there were 173 (94.4%) cases of clinical stage -Ⅱdisease and 7 cases (5.6%) of clinical stage III- disease. The 5-year overall survival (OS) rates in the gastrointestinal, ocular, and other groups were 96.7%, 95.5%, and 86.4%, respectively, and the difference was not statistically significant (P= 0.118). The 5-year progression-free survival (PFS) rates were 82.4%, 86.6%, and 86.4% in the corresponding groups, respectively, and the difference was not statistically significant (P=0.862). The single-factor correlation analysis of prognosis indicated that low hemoglobin (P=0.006) and high β2-microglobulin (P=0.013) levels were related to OS, while an increase in β2-microglobulin (β2-MG) (P=0.004) levels was related to OS and PFS. Survival analysis showed that a low hemoglobin level was significantly associated with OS (P=0.015). Conclusions: MALT lymphoma can originate from different parts of the body. Additionally, the patients show slow clinical progress, late recurrence, and long total survival. Low hemoglobin and β2-MG levels can be used as important indexes for clinical prognosis.
ABSTRACT
Objective To investigate the imaging characteristics of pulmonary mucosa-associated lymphoid tissue(MALT)lym-phoma,in order to improve the diagnosis of this disease.Methods X-ray and CT features of 1 9 cases of pulmonary MALT lympho-ma confirmed by operation or biopsy were retrospectively analyzed.Results Among 1 9 cases,there were 4 cases with a single nod-ule,2 cases with a single consolidation,5 cases with multiple consolidations,2 cases with a single patchy shadow,4 cases with patchy consolidations,1 case with multiple patchy shadows combined with irregular cavities,and 1 case with diffused interstitial changes.Grossus air bronchogram was found in 1 1 cases with nodules,consolidations and patchs.Irregular margin was found in 1 5 cases.Spiculation was found in 3 cases.Pleural retraction was found in 2 cases.Pleural effusion was found in 3 cases.Conclusion Pulmonary MALT lymphoma can be showed as solitary nodule,patchy shadow,consolidation,cavity and diffused interstitial change.Pulmonary MALT lymphoma should be considered if such lesions combined with grossus air bronchogram,irregular mar-gin,spiculation or plural retraction..