Increase of procalcitonin in infant muggy syndrome / 中国小儿急救医学

Objective To investigate the characteristics and clinical significance of increased procal-citonin( PCT) in infant muggy syndrome( IMS) .Methods A total of 23 IMS cases admitted in PICU from Nov 2011 to Apr 2012 were enrolled.All cases were devided into three groups according to pediatric critical illness score,high risk group(n=5),medium risk group(n=12),and mild risk group(n=6).And 23 cases were also divided into infection group and no infection group according to baseline disease before onset.The relationship of PCT and pediatric critical illness score,primary infectino and infection index weer observed, and the possible causes of icn reased PCT in IMS were explored.Twenty age mathc ed infants reec iving exami-nation in clinic served as control gor up.Re sults PCT inrc eased significantly in IMS cases.The PCT level was(91.5 ±90.9) ngm/l ni high risk group,(81.1 ±74.1) ng/ml in medium risk group,and(112.1 ± 74.9) ng/ml in mild risk group,there were no significant differences among trh ee groups( F=0.371,P =0.732).Other infection index like leukocyte conmt,neutrophil and C reactvi e prto ein in IMSg roup were higher thant hose int he cno trol group,and the results had significant differences( P<0.05,reps ectively) .The PCT level was(72.5 ±74.4) ng/ml in infce toi n group,(101.5 ±76.6) ng/ml in no infection rg oup,and there was on sing ificant difference between two groups(t=0.873,P=0.392).There was no relevance be-tween increase of PCT and the incidence of infection before IMS.But PCT had higher correlation to the body tem-perature after IMS(r=-0.362,P=0.049).Conclusion There is correlation between the increased PCT and fever in IMS,and fever in IMS would lead to inflammation and then resulted in the increase of PCT.

Clinical analysis and MRI diagnosis of infant muggy syndrome / 实用放射学杂志

Objective To investigate MRI findings and its relationship with clinical grading and prognosis of infant muggy syn-drome (IMS).Methods Twenty five cases of IMS diagnosed newly and nine cases of IMS with follow-up were collected.MRI find-ings were retrospectively analyzed and compared with their clinical data.Results Seven early abnormal signs could be shown on cer-ebral MRI examination.There was no correlation between the clinical grading and three abnormal signs,which were subdural effu-sion,supratentorial cerebral edema and subarachnoid hemorrhage (P >0.05).In contrast,the other four abnormal signs (abnormal signal of subcortex and cortex,diffuse cerebral hemorrhage,basal ganglia and corpus callosum edema or infarction,large area cere-bral infarction)were closely related to the severity of clinical symptom (P <0.05).MRI findings had certain correlation with clinical classification.Conclusion MRI can objectively reflect the serious change of brain damage in IMS,and provide important information for clinical therapy and prognosis.

The clinical significance of nuclear factor-κB activation in peripheral blood mononuclear cells, serum level of interleukin-17 and serum levels of other correlated inflammatory cytokines in infant muggy syndrome / 中国小儿急救医学

Objective To investigate the clinical significance of nuclear factor ( NF)-κB activation in peripheral blood mononuclear cells (PBMCs) and the serum levels of correlated inflammatory cytokines in children with infant muggy syndrome(IMS).Methods Blood samples from 100 patients with IMS and those from 32 healthy infants( control group)were detected by ELISA for amount of NF-κB activation in PBMCs and for serum levels of interleukin ( IL ) -17,IL-6,tumor necrosis factor ( TNF ) -α and IL- 10 respectively from Jan 2008 to Jan 2011.At the same time,blood samples from 46 out of the above 100 patients with IMS and those from the 32 controls for positive rate of activation of NF-κB in PBMCs were detected by flow cytometry as well.The relationship between all the data and multiple organ dysfunction syndrome( MODS ) were analyzed respectively.Results As compared with that of control group,the percentage of activated NF-κB in PBMCs in 100 patients with IMS detected by ELISA [ ( 11.042 ± 6.792 ) ％ vs ( 4.528 ± 1.378 ) ％ ] and the positive rate of NF-κB activation in 46 patients with IMS detected by flow cytometry [ ( 28.780 ± 13.820 ) ％ vs (7.078 ±5.395)％ ] were both significantly higher ( P ＜0.01 ).The serum levels of IL-17,IL-6 and IL-10were also significantly higher in patients with IMS than those in control group( P ＜0.01 ).The serum level of TNF-α was higher in patients with IMS than that in control group but without significance( P ＞ 0.05 ).The percentage of activated NF-κB [ ( 14.591 ± 7.626) ％ vs ( 8.576 ± 4.851 ) ％ ],the positive rate of NF-κB activation [ ( 36.087 ± 12.056) ％ vs ( 23.590 ± 11.263 ) ％ ],and the serum levels of IL- 17,IL-6,TNF-α and IL-10 were all significantly higher in IMS patients with MODS than those in IMS patients without MODS ( P ＜ 0.01 ).Conclusion The inflammatory factors of NF-κB activation in PBMCs and the high serum levels of IL-17 and IL-6 are potent to cause inflammatory damage in IMS patients,and the serum level of IL-10 is not able to compensate the damage.The activation of NF-κB and high serum levels of IL-17,IL-6 and TNF-α are correlated with MODS.

Protective Effect of Hyperoxia Liquid on Multiple Organ Damage during Ischemic Reperfusion Injury in Infants with Muggy Syndrome / 实用儿科临床杂志

0.05).But after the treatment,there were significant increases in pa(O2),SaO2 and PCIS(Pa0.05).Conclusions Early application of hyperoxia liquid could decrease multiple organ anoxia and the damage of lipid peroxidation.It has obviously protective effects on multiple organ damage during ischemic reperfusion in infants with muggy syndrome.

Risk Factors of Death in Infant with Muggy Syndrome / 实用儿科临床杂志

Objective To explore the risk factors of death in infant with muggy syndrome(IMS).Methods Sixty-three children with IMS were analyzed retrospectively, who admitted from Jan. 2002 to Feb. 2007,and these children were divided into groups according to the presence or absence of combined conditions including metabolic acidosis, hyperglycemia, hypocalcemia, ultrahyperpyrexia, pediatric critical illness score(PCIS) or number of the multiple organs failure. The ?2 test was used to examine the mortality between those groups.Results The total mortality of these children with IMS in-hospital was 22.1%. There were significant differences in mortality between combining metabolic acidosis and non-combining ones (RR=3.20,95%CI=1.0-10.24 ?2=4.76 P80 score (RR=12.73,95%CI=1.78-91.04,?2=13.24 P12 mmol/L and those