ABSTRACT
Objective To investigate three strains of vaginal Lactobacillus for their regulative effects on macrophage and murine uterocervical carcinoma number 14(U14).Methods Mice were transplanted with U14,then ramdomly divided them into 5 groups.Model group and DDP group respectively were regarded as nagative and positive comparison;Lactobacillus groups were injected with 1010 each with Lactobacillus into peritoneum for 10 days successively.The TNF-? and NO content secreted by KM mice and the inhibitory rate of U14 cells were detected.Results The production of TNF-? and NO secreted by the peritoneal macrophages activated by Lactobacillus was greatly increased.The three strains of Lactobacillus all had significantly antitumor effects on KM mice bearing U14.Conclusion Lactobacillus showed a marked inhibition effects on the U14 cells and can activate macrophages to produce TNF-?and NO which may be involved in the antitumor mechanism.