ABSTRACT
Spinal cord injury often leads to permanent disability or death,which can cause heavy burden to the family and society.Currently,there is no cure for spinal cord injury,the main purpose of the treatment is to preserve the residual function of the spinal cord to the greatest extent.In this review,the recent advances of the therapy of spinal cord injury will be elaborated in two aspects,including the neuroprotection and the neuranagenesis,and the past treatment strategies will be reassessed,in order to strengthen the understanding of the treatment of spinal cord injury,so as to provide a reference for the formulation of more effective clinical therapy.
ABSTRACT
@# Objective To explore the effect of Tuina combined with treadmill training on nerve regeneration after sciatic nerve transection. Methods Ninty-six Sprague-Dawley rats were randomly divided into normal group (n=32), model group (n=32) and treatment group (n=32). The sciatic nerve was transected and the epineurium was sutured in the latter two groups. The treatment group was given Tuina manipulation and treadmill training once a day. Eight rats from each group were detected their sciatic nerve conduction velocity (NCV), the number of axons and Schwann cells (SCs) two, three, four and eight weeks after intervention. Results Compared with the model group, the NCV accelerated in the treatment group four and eight weeks after intervention (P<0.05); while the number of axons was significantly different two and four weeks after intervention (P<0.05), and the number of SCs was not very different between the treatment group and the model group after intervention (P>0.05). Conclusion Tuina combined with treadmill training may promote the regeneration of peripheral nerve after injury in rats.
ABSTRACT
Erythropoietin (EPO),which is routinely used in clinic to treat anemia,has been implicated in a wide range of activities on diverse tissues.Recently,accumulating evidence shows that EPO has antidepressant-like effects and may be a po-tential drug candidate for treating mood symptoms and memory dysfunction in depression.This review summarizes the current progress on EPO’s antidepressant-like effects,and explores its potential mechanism and clinical application in the future,provi-ding a general view of the research and application status of EPO in depression.