Use of Tachosil® as an adjuvant therapeutic option in neurotrophic keratopathy in order to prevent perforation

We present two cases of women who suffered from neurotrophic keratopathy (one of them had undergone penetrating keratoplasty) which had led to corneal thinning. Tachosil® was used as an adjuvant treatment after topical medication by itself failed in both cases. To our knowledge, there are no reported cases of the use of Tachosil® in corneal grafts.

Research advances in relationship between substance P and neurotrophic keratopathy and its application / 中华实验眼科杂志

Neurotrophic keratopathy is caused by a variety of factors that damage the corneal sensory nerves,resulting in hypoesthesia of cornea,corneal dystrophy and inflammatory changes.The manifestations of neurotrophic keratopathy are recurrent or persistent corneal epithelial defects,delayed corneal wound healing,corneal ulcers and even perforation.There are still some difficulties in therapy targeting to nerve plerosis.Substance P,as a neurotransmitter,is expressed in ophthalmic nerves and many cell types,including corneal epithelial cells,stromal cells and immunological cells,and exerts its biological functions by activating intracellular signaling pathways.Recently,with the increasing researches of substance P,the treatment of neurotrophic keratopathy is gradually changing.This paper retrospected the clinical features and pathogenesis of neurotrophic keratopathy,summarized the association between substance P and neurotrophic keratopathy from the perspective of infection,surgery and systemic disease,and the prospects of substance P application in neurotrophic keratopathy.

Queratopatía neurotrófica severa en paciente con compromiso bilateral del reflejo palpebral con diferente sustrato neurológico pos-TEC: reporte de un caso / Severe Neurotrophic keratopathy in patients with bilateral involvement of blink reflex with different neurological lesion post TBI: a case report

Se presenta el caso de un paciente que experimentó un TEC severo, asociado a fracturas de huesos craneales y lesión de pares craneales: II par izquierdo, ramas sensitivas corneales y oculares de la primera rama del trigémino derecho, y VII par izquierdo. Secundario a lo anterior, en el paciente se alteró el reflejo palpebral de manera bilateral, pero con un sustrato neurológico diferente. Con el paso del tiempo, ya en fase crónica pos-TEC, el paciente desarrolló una queratopatía neurotrófica severa. Es un caso llamativo por la correlación neuroanatómica que exige y el papel trófico epitelial que representa el nervio trigémino a nivel corneal y porque otorga información al personal médico en neurociencias clínicas para predecir la aparición de una complicación compleja de tratar como lo es la queratopatía neurotrófica. Son escasos los reportes en la literatura de esta temática, asociada a TEC y lesión de diferentes pares craneanos.

A case report of a patient with severe TBI associated with fractures of the skull base and cranial nerve involvement: II left cranial nerve, sensitive fibers from de V right cranial nerve and VII left cranial nerve. Because of complex lesions in cranial nerves, the patient had bilateral altered blink reflex. During the follow-up the patient developed severe neurotrophic keratopathy because. This is a rare cause of corneal lesion secondary to the damage to the trigeminal fibers which has a protective effect in the corneal epithelium. It is also important because could be a complications that could be avoidable en patients with severe TBI with an early diagnosis and treatment. There are few cases reported in the literature.