ABSTRACT
Mitochondrial aldehyde dehydrogenase(ALDH2),one of the isoforms of aldehyde dehydrogenase,has multiple enzymatic functions including the activity of dehydrogenase and esterase.The metabolisms of ethanol,amino acids,biogenic amine,vitamin or steroid in the body produce various substances of aldehyde.With the help of co-factor NAD(P)+,ALDH2 can convert aldehydes into corresponding carboxylic acid,which plays a key role in reducing toxic effects of aldehydes on the body.It does not need co-factor when ALDH2 works as esterase.It can convert carboxylic ester or other acids into corresponding carboxylic acids or alcohols.Recently,it has been shown that the decrease of ALDH2 activity exacerbates multiple factors(such as ethanol,ischemia)-induced myocardial injury and accelerates the development of nitroglycerin tolerance.Therefore,the development of specific agonists of ALDH2 may provide a novel approach to the therapy and prevention of heart diseases.
ABSTRACT
Objective: To observe clinical therapeutic effective of 5 mono nitre isosorbide combined with ginkgo leaf in the treatment of angina pectoris. Methods:100 cases of angina pectoris were randomly divided into control group (5 mono nitre isosorbide) and treated group (5 mononitre isosorbide combined with ginkgo leaf). The therapeutic course lasted four monthes. Results: Nitroglycerin consumption in treated group was lower significantly than that in control group. The effective rate was 94.8% in the treated group and 84.2% in the control group after four monthes ( P