ABSTRACT
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by destructive cholangitis affecting the small intrahepatic bile ducts, and the presence of antimitochondrial antibodies (AMA). At present, there has been limited progress in exploring the pathogenesis of the disease, because of difficulty in obtaining human tissue samples and lack of suitable animal models. In recent years, some murine models have been reported, which showed serological, biochemical, and histological characteristics similar to those of humans with PBC. In this review, various murine models of PBC are reviewed, and the characteristics and mechanism of PBC in mice are introduced. Besides, their advantages and limitations in the study of PBC are discussed. It hopes to provide an important theoretical basis for studying the pathogenesis of PBC and developing therapeutic drugs for PBC.
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Objective:With the increasing awareness of physical examination,the physical examination market met a great opportunity.Under the background of the government encouraging private capital to enter the medical market,it studied the business differences between physical examination in state-owned hospitals and private hospitals.Methods:Synthetically compare service capacity,business income and cost benefit of physical examination in state-owned hospital with that in private hospital were compared to study medical center's business advantages and disadvantages in different operation modes.Results:Physical examination in state-owned hospitals and private hospitals had their own advantages and disadvantages.Conclusion:Under the new situation,it needed to adhere to the public interest nature of physical examination in state-owned hospital,support the healthy development of physical examination in private hospitals,encourage state-owned hospitals and private hospitals to cooperate in physical examination,which had complementary advantages.
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A amplitude das atribuições da vigilância da qualidade da água para consumo humano (VQACH) associada à heterogeneidade dos municípios brasileiros (perfil demográfico e epidemiológico, recursos humanos e financeiros) impõe ao nível local de gestão o desafio de implementar com efetividade e sustentabilidade as ações previstas no modelo de atuação da VQACH. Tendo como cenário de estudo um município mineiro de pequeno porte, o trabalho apresenta desafios e possibilidades vivenciados durante a implementação do modelo. O atendimento às ações estratégicas e básicas e aos princípios doutrinários, organizacionais e executivos previstos no modelo de atuação foi verificado e as estratégias para o enfrentamento dos desafios impostos ao exercício da VQACH foram apresentadas. A conformação de uma equipe de profissionais em quantidade e qualidade compatíveis com as ações de VQACH foi aspecto fundamental, além da melhor explicitação de procedimentos como análise integrada dos sistemas de informação e análise e classificação do grau de risco à saúde das diferentes formas de abastecimento de água. O estudo permite adiantar aos gestores dos diferentes níveis de governo desafios e estratégias para contorná-los, bem como instrumentaliza a coordenação da VQACH no nível federal sobre questões que necessitam tratamento mais detalhado e específico...
The magnitude of drinking-water quality surveillance (DWQS) attributions in meeting its primary function of health protection, associated with the heterogeneity of Brazilian municipalities (demographic and epidemiological profile, human and financial resources), is an important challenge in implementing actions which are effective and sustainable at the local level. The study presents the experience in rolling out the national operation model for DWQS in a small municipality in Minas Gerais state. The paper whether the strategic and basic actions and the doctrinal, organizational and executive principles provided in the operation model were achieved and how they were accomplished. Also, certain strategies for confronting the challenges imposed by DWQS assignment were presented. The existence of a well prepared and measured professional team is a fundamental aspect in achieving the DWQS objectives. In addition, some procedures should have clear guidelines, such as the integrated analysis of information systems and analysis and health risk classification of water supplies. In conclusion, different challenges must be overcome to implement drinking-water quality surveillance at the local level and managers could experience some difficulties. Federal level managers should be aware of issues that require more detailed and specific treatment...
Subject(s)
Humans , Water Supply , Drinking , Water Quality , Environmental Health , Water Purification , Environmental Health Surveillance , Drinking Water , Health Promotion , Unified Health SystemABSTRACT
To establish a new kind of minimally invasive surgical model of transurethral prostate enucleation operation and method that makes the operation easier and reduces the surgeon learning curve.According to the order and the path of surgical operation,prostate enucleation operation is split into 4 different modules named as A,B,C,D,and it is called modular transurethral enucleation of the prostate.The operation mode optimizes the process of operation design, modularizes the contents of surgical procedures,processes,and reduces the difficulty of the operation,and simplifies the surgical procedure,which can effectively shorten the operation time and make it easy for beginners to carry out and control the procedure.It has a great popularization value.
ABSTRACT
Objective To study the effect of Mushao composition on ?-EP and CCK-8 in the caudex dorsalis of rats with pain after fracture operation,and explore its mechanism.Methods The male Wistar rats were randomly divided into control group,model group,Mashao composition group and tramadol group.The Brennan model was adopted.The level of the ?-EP and CCK-8 were determined by the method of radioimmunity.Results Compared with model group,Mushao composition could increase level of ?-EP in the caudex dorsalis,while decrease level of CCK-8.Conclusion Mushao composition could increase the content of ?-EP and reduce the content of CCK-8,so to analgesia in rats model of pain after fracture operation.