ABSTRACT
White lesions are relatively frequent in the oral cavity with a prevalence of approximately 24.8%. Among them is oral leukoplakia with a prevalence rate of 0.2–3.6%. There were various debates about the verrucous carcinoma and PVL (proliferative verrucous leukoplakia) being different entities or a part of spectrum at different stages of the disease process. In this article we are reporting a case with coexistence of two different histological features in the form of verrucous carcinoma and PVL of oral cavity with a need to throw some light to understand the pathogenesis of premalignant lesions.
ABSTRACT
Cowden syndrome or multiple hamartoma syndrome is an autosomal dominant condition with variable expressions that result mainly from mutation in the PTEN gene on arm 10q. It is characterized by multiple hamartomatous neoplasms of the skin, oral mucosa, gastrointestinal tract, bones, CNS, eyes, and genitourinary tract. Mucocutaneous features include trichilemmomas, oral mucosal papillomatosis, acral keratosis, and palmoplantar keratosis. Here we present a case of Cowden syndrome in a 14-year-old female patient with the chief complaint of multiple oral papillomatous lesions.