ABSTRACT
Background: Dermatophytosis is a geographically widespread group of fungal infections. Tinea corporis and tinea cruris are the most common dermatophytoses in Bangladesh. Oxiconazole has recently been introduced in Bangladesh in the treatment of dermatophytoses. Objective: To evaluate the efficacy of topical 1% oxiconazole cream once daily in the treatment of tinea corporis and tinea cruris. Materials and Methods: A clinical trial was carried out in the department of Dermatology and Venereology, Jalalabad Ragib-Rabeya Medical College Hospital, Sylhet on 81 patients with tinea corporis and/or tinea cruris. The patients were instructed to apply 1% oxiconazole cream once daily for 2 weeks with clinical assessment made at weekly intervals during treatment period. Results: The mean age of the patients was 32.5 ± 10.5 years, with tinea corporis in 47 (58.0%) patients and tinea cruris in 34 (42.0%). The mean clinical assessment score declined from 6.6 ± 1.3 at baseline to 3.9 ± 1.2 at week 1, 0.9 ± 1.3 at week 2 and 0.7 ± 1.1 at week 4. Reduction of clinical assessment score from baseline to end of the treatment period was statistically significant (p<0.001). The improvement of clinical score was from baseline to 41.6% at week 1, 89.3% at week 2 and 91.5% at week 4. Improvement of clinical score from baseline to end of the treatment period was statistically significant (p<0.001). Global response was clear in 55 (67.9%) patients, good in 25 (30.9%) patients and fair in 1(1.2%) patient. Clinical efficacy was cure in 55 (67.9%) patients, improvement in 25 (30.9%) and failure in 1(1.2%) patient. Conclusion: Once daily topical administration of oxiconazole cream is highly effective in the treatment of superficial fungal infections of the skin.
ABSTRACT
Oxiconazole, a new broad-spectrum antifungal agent, was synthesized accordi ng to the method reported by Mixich G et al and some improvement was made in the preparation of N- (2, 4-dichlorobenzoylmethyl) imidazole, an important intermediate.In an effort to search for more effective antifungal drugs by chemical modification, several imidazolyl oxime ether derivatives were synthesized.The structures of the synthetic products were proved by elemental analysis.In vitro fungistatic tests showed that compounds Ⅰ-Ⅷ were more effective than clotri-mazole against most of the fungal strains tested and that compound Ⅲ possessed antifungal action against Aspergillus while others didn't.The structure of compound I(oxiconazole)was confirmed by UV, IR, 1H-NMR and MS.Its X-ray powder diffraction data are also provided.In a clinical trial,94.10% of the patients with tinea cruris were cured after a two-week oxiconazole treatments cure rate significantly higher than that of econazole(84.24%, P