ABSTRACT
OBJECTIVE: To study the chemical constituents of the roots of Rhodiola crenulata. METHODS: The roots of R. crenulata were extracted with 80% ethanol, and the extract was partitioned with ethyl acetate. The chemical components were isolated by various chromatographic methods. Their structures were elucidated by spectral analysis. RESULTS: Eleven compounds were isolated and identified as isolariciresinol-9, 9′-acetonide (1), p-coumaric acid (2), p-coumaric acid-4-O-β-D-glucopyranoside (3), tachio-side (4), dihydroconiferin (5), 2-phenylethyl β-glucopyranoside (6), 2-phenylethyl β-vicianoside (7), 2-phenylethyl-6-0-α -L-arabi-nofuranosyl-β-D-glucopyranoside(8), 2-phenylethyl β-primeveroside (9), benzyl β-D-glucopyranoside (10), and rhodiocyanoside D (11). CONCLUSION: All of the compounds were isolated from Rhodiola crenulata for the first time, and compounds 1, 3, 4, 5, 7, 9 were obtained from the genus of Rhodiola for the first time.