Surgical and nonsurgical treatment of papillary hyperplasia: A case report / Tratamiento quirúrgico y no quirúrgico de la hiperplasia papilar inflamatoria: Reporte de Caso

Dentures with dental plaque predispose recurrent hyperplasia on the palatal mucosa. Surgical procedures for the treatment of inflammatory papillary hyperplasia involve postsurgical discomfort and morbidity. This repot describes clinical and histologic aspects of a patient with severe akantolitic inflammatory papillary hyperplasia. The palatal mucosa was treated with a surgical bur with a low-speed handpiece. A new removable denture was performed and adapted. A follow-up of 4 years showed staility of health at palatal mucosa. Patient referred low discomfort and morbidity when using bur technique. Control of removable denture was critical for long-term healing and soft tissue stability.

Las prótesis dentales con placa bacteriana predisponen a la hiperplasia recurrente en la mucosa palatina. Los procedimientos quirúrgicos para el tratamiento de la hiperplasia papilar inflamatoria implican molestias y morbilidad posquirúrgicas. Este reporte describe los aspectos clínicos e histológicos de un paciente con hiperplasia papilar inflamatoria acantolítica severa. La mucosa palatina fue tratada con una fresa quirúrgica con una pieza de mano de baja velocidad. Se realizó y adaptó una nueva prótesis parcial removible. Después de un seguimiento de 4 años, se encontró estabilidad de la salud de la mucosa palatina. El paciente se refirió a la baja incomodidad y morbilidad al usar la técnica de la fresa. El control de la prótesis parcial removible fue crítico para la cicatrización a largo plazo y la estabilidad de los tejidos blandos, evitando la recidiva de la hiperplasia papilar inflamatoria.

Hiperplasia papilomatosa del paladar en pacientes con prótesis dental / Papillary hyperplasia of the palate in patients with dental prosthesis

Se efectuó un estudio descriptivo y transversal de 40 pacientes con prótesis total y/o parcial removible, afectados por hiperplasia papilomatosa del paladar, atendidos en la consulta estomatológica del Policlínico de Especialidades del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de Santiago de Cuba, desde mayo de 2013 hasta igual mes de 2015,con vistas evaluar los resultados del diagnóstico clínico e histopatológico e identificar los factores de riesgo de esta enfermedad. En la casuística predominaron el sexo femenino, el grupo etario de 60 años y más, así como la ausencia de síntomas en 60 % de ellos. Entre los principales factores predisponentes figuraron las prótesis desajustadas y el uso de estas por tiempo prolongado y continuo; asimismo, las alteraciones hísticas más comunes resultaron ser la pérdida de la continuidad del epitelio mucoso, el infiltrado inflamatorio crónico y la hiperplasia de la capa basal, respectivamente.

A descriptive and cross-sectional study of 40 patients with total and/or partial removable prosthesis, affected by papillary hyperplasia of the palate, assisted in the Specialties Polyclinic stomatological service of "Saturnino Lora Torres" Teaching Clinical Surgical Provincial Hospital in Santiago de Cuba, was carried out from May, 2013 to the same month in 2015, aimed at evaluating the results of the clinical and histopathological diagnosis and identify the risk factors of this disease. In the case material the female sex, 60 years and over age group, as well as the absence of symptoms in 60% of them prevailed. Among the main predisposing factors there were the maladjusted prosthesis, and its use during long and continuous time; also, the most common tissue disorders were the loss of the continuity of the mucous epithelium, the chronic inflammatory infiltrated and the basal layer hyperplasia, respectively.

Clinical Significance of CK19, CD56 and p53 in differential diagnosis of papillary thyroid microcarcinoma and thyroid papillary hyperplasia / 肿瘤研究与临床

Objective To investigate the expression and diagnostic significance of CK19,CD56 and p53 protein in papillary thyroid microcarcinoma and thyroid papillary hyperplasia.Methods The expressions of CK19、CD56 and p53 protein were detected in 52 cases of papillary thyroid microcarcinoma and 31 of thyroid papillary hyperplasia by iImmunohistochemical methods.Results The positive rate of CK19 expression was 100 ％ (52/52) of papillary thyroid microcarcinoma and 29.0 ％ (9/31) in 31 of thyroid papillary hyperplasia.There was significant difference between two groups (P ＜ 0.001).CK56 in 2 cases (3.8 ％) of papillary thyroid microcarcinoma appeared mild positive expression,and in 20 cases (66.7 ％) of thyroid papillary hyperplasia positive expression (P ＜ 0.001).The positive expression rates of p53 were 69.2 ％(36/52) in papillary thyroid microcarcinoma and 6.5 ％ (2/31) in thyroid papillary hyperplasia (P ＜ 0.001).Conclusion CK19,CD56 and p53 may be important value on differential diagnosis of papillary thyroid microcarcinoma from thyroid papillary hyperplasia,and they are the indispensable markers of differential diagnosis.

Denture-related hyperplasia: a clinical study of a turkish population group

Inflammatory fibrous hyperplasia (epulis fissuratum) (IFH) and inflammatory papillary hyperplasia (IPH) are oral mucosal diseases caused by ill-fitting denture wearing. A study was carried out on a group of Turkish people consisted of 131 female and 39 male complete denture wearers (n= 170) distributed in two age groups (30-60 and 60-80 years old). The analysis of data collected from patients showed that while the incidence of IFH was higher in women than in men, the incidence of IPH was similar. Most lesions were found in the 30-60 year-old group. The incidence of lesions increased as the denture wearing period increased. Soft tissue growth was the main complaint of the patients with IFH and IPH. In the maxilla, the incidence of IFH was higher than IPH. There was also a significant difference between the distribution of the lesion types in the jaws. There were a larger number of lesions in the maxilla compared to the mandible and most IFH lesions were located in the anterior region of the jaws.

A hiperplasia fibrosa inflamatória (epulis fissuratum) (HFI) e a hiperplasia papilar inflamatória (HPI) são doenças da mucosa causadas por próteses mal-ajustadas. Foi feito um estudo num grupo de pessoas, na Turquia, composto por 131 mulheres e 39 homens (n=170) usuários de próteses totais. O grupo foi subdividido em duas faixas etárias (30 a 60 e 60 a 80 anos). A análise dos dados coletados dos pacientes mostrou que a incidência de HFI foi mais alta entre as mulheres, ao passo que a incidência de HPI foi similar em ambos os sexos. A maioria das lesões foi encontrada no grupo indivíduos de 30 a 60 anos. A incidência das lesões aumentou com o tempo de uso da prótese. A queixa principal dos pacientes com HFI e HPI foi o aparecimento de tecidos moles. A incidência de HFI foi maior do que HPI, na maxila. Houve também diferença significativa de distribuição dos tipos de lesão nos maxilares. Houve maior número de lesões na maxila, em comparação com a mandíbula e a maioria das lesões HFI estava localizada na parte anterior dos maxilares.

Differential diagnostic usefulness of CK19, S-100 protein and EMA in papillary carcinoma and papillary hyperplasia / 中国癌症杂志

Purpose: To evaluate the diagnostic utility of detection of Cytokeratin 19 (CK19), b-100 protein and epithelial membrane antigen ( EMA) in thyroid papillary carcinoma, follicular carcinoma and papillary hyperplasia. Methods: 65 thyroid lesions were stained immunohistochemically for CK19, S-100 protein and EMA. Results: CK19, S-100 and EMA are negative in all papillary hyperplasia. CK19 expression was strong and diffuse in 100% of papillary carcinoma including the follicular variant of papillary carcinoma, and was positive in 22% of follicular carcinoma. S-100 and EMA were respectively present in 61% and 100% of classic papillary carcinoma, in 38% and 54% of follicular variant of papillary carcinoma and in 44% and 11 % of follicular carcinoma. Conclusions: Our observations suggest that the expression of CK19, in combination with S-100 and EMA expression, is helpful in the diagnosis of thyroid lesions. CK19 is a valuable marker in the distinction of papillary carcinomas from papillary hyperplasia.

Cell Kinetic Evaluation of Bromodeoxyuridine and Proliferating Cell Nuclear Antigen Expressed Cells in Experimental Bladder Tumorigenesis Using Color-Image Analysis / 대한비뇨기과학회지

A study was carried out to define the role of color-image analysis in evaluation of immunohistochemically labeled cells using anti-BrdU monoclonal antibody and anti-PCNA/cyclin monoclonal antibody, and to clarify the characteristic of nodular or papillary hyperplasia lesion using color-image analysis. Sequential cellular changes(normal, simple hyperplasia, nodular or papillary hyperplasia, and transitional cell carcinoma-Ta, T1) were observed in Fisher 344 rat urinary bladder depending on the duration of BBN administration. The mean BrdU labeling index obtained using color-image analysis and visual analysis showed statistically significant difference between normal and simple hyperplasia, and nodular or papillary hyperplasia and bladder tumor, but no difference between simple hyperplasia and nodular or papillary hyperplasia. The mean PCNA labeling index obtained by color-image analysis and visual analysis in normal, simple hyperplasia, nodular or papillary hyperplasia and bladder tumor. showed statistically significant difference in each histological group. But coefficient of variation of mean BrdU labeling index obtained by color-image analysis was higher than that by visual analysis only in normal bladder mucosa, and was lower in simple hyperplasia, nodular. or papillary hyperplasia, and bladder tumor. Coefficients of variation of mean PCNA labeling index obtained by color-image analysis were lower than those using visual analysis in all lesions. Higher BrdU and PCNA labeling indices indicated greater biological malignant potential,and mean labeling index in each histological group obtained by both color-image and visual analyses progressively increased with tumorigenesis. The coefficients of variation with color-image analysis were lower than those with visual analysis in general, therefore. the evaluation of labeling indices obtained using color-image analysis was more reliable than that obtained using visual analysis. Nodular or papillary hyperplasia showed rather a premalignant lesion in dynamic process than the previous concept of two separated entities, reversible or irreversible lesion, when evaluated more reliably by color-image analysis. The data suggest that cell kinetic evaluation using color-image analysis provide more reliable information to evaluate immunohistochemical staining in terms of quantitation and reproducibility and play an important role in predicting proliferative activity and malignant potential for bladder tumor.