ABSTRACT
Objective To investigate the clinical effects of different drug treatment on early onset severe preeclampsia.Methods 80 patients with early onset severe preeelampsia were randomly divided into two groups:Pell horizon treatment( group A) 40 cases and phentolamine treatment (group B) 40 cases, blood pressure, serum Ca2+,Mg2+ concentration and protein in urine were observed before and after treatment in .Results The mean arterial blood pressure in medication over 24 hours compared with that before treatment were significantly decreased in two groups ( t = 2.351,2.315, all P < 0.05 ) ; After treatment reduced urinary protein was observed in two groups, before and after tratment there were no significant difference ( t = 1.289,1.287, all P > 0.05 ) ; The contents of Ca2+, Mg2+After treatment were higher than before treatment ( t = 2.298,2.311, P < 0.0) ; The time of average pregnancy in group A was significantly longer thar that in group B ( x2 = 3.714,P < 0.05 ) ;The number of Apgar score more than 8 points in group A was significantly higher than the group B( x2 = 3.784 ,P < 0.05 ).Conclusion Perdipine with magnesium sulfate had affirmative curative effect in the treatment of early onset severe preeclampsia,and it was deserved to be applied.
ABSTRACT
Objective To study the influence of perdipine on the proliferation and proline-rich tyrosine kinase 2 (PYK_ 2 ) expression in cultured adult rat cardiac fibroblast stimulated by angiotensin Ⅱ, and to explore the mechanism of perdipine on cardiac fibrosis. Methods Adult rat cardiac fibroblasts (CFs) were treated with angiotensin Ⅱ(AngⅡ) to establish fibrosis model. The effects of perdipine on proliferation of CFs were analysed by MTT colorimetric assay, and fibronectin was tested by immunohistochemistry method. PYK_ 2 mRNA and protein level were examined by RT-PCR and Western blot analysis respectively. Results Perdipine inhibited CFs proliferation and fibronectin synthesis stimulated by angiotensin Ⅱ in a dose dependent, and the levels of PYK_2 mRNA and protein were decreased significantly. Conclusion Perdipine can inhibit cardiac fibrosis stimulated by angiotensin Ⅱ by suppressing CFs proliferation and fibronectin synthesis. PYK_2 is involved in the effect of perdipine.