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Polycystic Ovarian Syndrome (PCOS) is one of the most common endocrine disorders that affectingwomen in reproductive age. Incidence rate isabout5% to 10% in this age group. Nursesare in a position to improve attitude of individualsaffected with the syndrome, soenhancing the attitudeof nursing students regarding PCOS will help to modify attitude ofgeneral population. Aim of the study was to improve the attitudeof B.Sc. Nursing students regarding PCOS.Quasi experimental research approach,non-randomized control group pre-test-post–test design was used.80 B.Sc. Nursing students were selected by using purposivesampling technique.Likert scalewas used to collect the data from the samples.Result of the study revealed that in experimental group, mean pre-test attitude score was 54.70,more than half 75%of the nursing studentshad unfavorable attitude, 25%had moderately favorable attitudeand none of them had favorable attitude, Mean post-test attitudescore of B.Sc. Nursing students was 93.72, none of the nursing studenthad unfavorable attitude, 15% had moderately favorable attitudeand 85% had favorable attitude. In comparison group, Mean pre-test attitudescore of B.Sc. Nursing students was 55.22, more than half of the nursing students 87.5% had unfavorable attitude, 12.5%had moderately favorable attitudeand none of the nursing studenthad favorable attitude, Mean post-test attitudescore of B.Sc. Nursing students was 55.20, more than half of the nursing students 87.5% had unfavorable attitude, 12.5%had moderately favorable attitudeand none of the nursing student had favorable attitude.
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Background: Polycystic ovarian syndrome (PCOS) is one ofthe most frequently encountered hormonal disorder withmetabolic abnormalities in females that can present at puberty,during reproductive age or even after menopause. Therefore,the aim of this study was to evaluate the occurrence of differentphenotypes among PCOS women and to compare thehormonal assay and metabolic profile of different phenotypesof PCOS.Materials & Methods: The present study was an observationalstudy conducted on 160 women of the age group of 16-35years and diagnosed with PCOS, in the department ofobstetrics and Gynecology at Mahatma Gandhi MedicalCollege and Hospital, Jaipur from January 2017 to July 2018.Diagnosis of PCOS was done by using the ESHRE/ASRMcriteria and subjects were divided into 4 phenotypes by usingthe all probable combination of Rotterdam criteria. Hirsutismwas assessed by using Modified Ferriman Gallwey score.Score <8 - Normal, 8-15- Mild and >15 indicate moderate tosevere hirsutism.Results: 160 PCOS women were distributed in 4 phenotypesand the most prevalent phenotype was phenotype D, 40.63%followed by 32.50% phenotype A and 14.38% phenotype C.Mean age of overall women was 24.94±4.86. In this studyoverall prevalence of metabolic syndrome was 37.5%. Almost50% women of phenotype A had metabolic syndrome followedby 35% of phenotype B, 34.78% of phenotype C and leastprevalence was in phenotype D 30.77%.Conclusion: We concluded that the most prevalent phenotypeis nonhyperandrogenic phenotype 40.63% and least commonphenotype is classic nonpolycystic ovaries phenotype(12.50%).
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Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. It is characterized by hyperandrogenism, rare ovulation or anovulation, and ovarian polycystic changes. Due to the heterogeneity of clinical manifestations, the pathogenesis of PCOS has not yet been fully elucidated, but genetic factors are considered to be the main pathogenesis of PCOS. Changes in epigenetic modifications such as DNA methylation and X-chromosome inactivation patterns may affect the expression of androgen receptor genes and insulin genes, thereby altering androgen activity, increasing androgen levels, and ultimately leading to PCOS. Peroxisome proliferator activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. Peroxisome proliferator activated receptor γ (PPARG) is the major expression subtype of the PPARs family in ovarian granulosa cells. PPARG plays an irreplaceable physiological function in reproduction and metabolism. It is involved in ovarian steroid metabolism, ovarian tissue remodeling, granulosa cell cycle regulation and insulin-glucose metabolism. Further research on the role of PPARG in the pathogenesis of PCOS can provide a theoretical basis for the prediction, diagnosis and treatment of long-term complications, which is reviewed by this article.
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Objective To observe the clinical efficacy of the combination of western medicine with acupuncture for treatment of polycystic ovary syndrome (PCOS) of infertility.Methods Totally 120 PCOS patients were randomly divided into western medicine group and acupuncture group, 60 cases in each group. All patients took Diane-35, and with whom resistant to insulin were added with Metformin. At the meantime patients increased the amount of exercise with adjustment and control of everyday diet. After three periods, the western medicine group used the method of Clomifene Citrate with Chorionic Gonadotropin to help ovulation induction. The acupuncture group used the method of acupoint selection including invigorating spleen and kidney with adjusting qi and blood to promote ovulation. The level of FSH, LH, FINS, E2 and T of the two groups were observed before and after treatment.Results After treatment, the levels of T, FINS, LH and BMI in the two groups decreased, with statistical significance (P<0.05). The levels of T and BMI in the acupuncture group were lower than the western medicine group after the treatment, with statistical significance (P<0.05). The total efficiency, gestation number, number of high-quality follicle, and basal body temperature of acupuncture group were all higher than the western medicine group, with statistical significance (P<0.05).Conclusion The combination of western medicine with acupuncture for treatment of PCOS of infertility has confirmed efficacy.
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<p><b>OBJECTIVE</b>To compare clinical efficacy differences between"regulating conception-governor vessel" acupuncture method and clomiphene for infertility of polycystic ovarian syndrome (PCOS).</p><p><b>METHODS</b>One hundred patients of PCOS were randomly assigned into an observation group and a control group, 50 cases in each one. The patients in the observation group were treated with"regulating Conception-Governor Vessel" acupuncture method at Zhongwan (CV 12), Guanyuan (CV 4), Qihai (CV 6), Zhongji (CV 3), Mingmen (GV 4), Yaoyangguan (GV 3) and Yaoshu (GV 2). The acupuncture treatment started at the end of menstruation, once every other day; after four treatments, the follicle was tested with B ultrasound; when follicle was longer than 18 mm or above, the acupuncture treatment was given once a day until follicle was discharged and acupuncture treatment finished. The patients in the control group were treated with oral administration of clomiphene from 5 days into menstruation, 50 mg per day for 5 consecutive days. Both groups were treated for three menstruation cycle. The menstrual cycles, endometrial thickness, endometrium types (A, B and C), cervical mucus scores, basal body temperature (BBT), cases of ovulation, cases of pregnancy were observed.The levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E), prolactin (PRL), progesterone (P) and testosterone (T) in serum were detected before and after the treatment.</p><p><b>RESULTS</b>After the treatment, the menstrual cycles were shortened (both<0.05),the endometrial thickness and cervical mucus scores were increased in the two groups (<0.05,<0.01); the improvement of endometrial thickness and cervical mucus score in the observation group were higher than those in the control group (both<0.01). The percentages of type-A endometrium in both groups were higher than those before the treatment (both<0.05); the number of type-A endometrium in the observation group was higher than that in the control group (<0.05). The ovulation rate was 88.0% (44/50) in the observation group, which was superior to 70.0% (35/50) in the control group (<0.05). After treatment, the levels of LH were reduced in the two groups (<0.05,<0.01), which was more significant in the observation group (<0.05).</p><p><b>CONCLUSIONS</b>The"regulating Conception-Governor Vessel" acupuncture method could improve menstrual cycles, increase endomet-rial thickness and promote the development of follicles in PCOS patient; in addition, it could decrease serum LH level, improve the ovarian functions and increase ovulation rate, which is superior to oral administration of clomiphene.</p>
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[Summary] Patients with infertility and non-obese polycystic ovary syndrome ( PCOS) were treated with continuous subcutaneous pulse infusion of GnRH. After the treatment, a 32-year old female had regular menstrual cramps. Dominant follicle occurred after 2 months of treatment. The patient was pregnant and now has a healthy baby boy. It shows that the pulse infusion of GnRH could induce spontaneous ovulation and natural fertilization of the patients with non-obese PCOS.
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Background: With all the modern needs of contraception rising on one side, infertility is still a major challenge to the gynaecological practitioners on other hand. Polycystic ovarian syndrome (PCOS) is the most common cause of anovulatory infertility, being found in ∼75% of cases. PCOS now proves to be a significant factor in female infertility with prevalence of 0.6 to 3.4% in infertile couples. With improving laboratory facilities, sonography and with routine laparoscopic evaluation of infertility, PCOS has shown a remarkable increase of incidence in recent years. Aims & Objective: The diagnosis of PCOS by ultrasonography & investigations like LH, FSH, Prolactin and or Laparoscopy. The evaluation of treatment options like clomiphene citrate, metformin and laparoscopic ovarian drilling. Material and Methods: This is a study of 100 cases of infertility with polycystic ovarian syndrome and its pregnancy outcome. In this study from May 2011 to April 2013,100 cases of Infertility with PCOS were studied at the tertiary care center. Hormonal assay, Ultrasound and laparoscopy were used for diagnosis. Clomiphene citrate, metformin and laparoscopic ovarian drilling were used as treatment modalities. Results: In our study 58% patients were in the age group of 21-25 years and 100% patients complained of infertility among which 60% were of primary type. LH:FSH ratio was more than 1.6 in nearly 82% patients. Among all treatment modalities conception rate with Clomiphene citrate was 40%, with metformin it was 20% and with laparoscopic ovarian drilling followed by C/C it was 65%. Conclusion: PCOS is emerging disease of the new generation found more in young adults being the leading cause of infertility. Apart from diet and exercise changes in lifestyle modification treatment is required in most patients with good conception rate with C/C and laparoscopic ovarian drilling.
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Polycystic ovarian syndrome (PCOS) is a low grade inflammatory disease characterized by hyperandrogenemia and chronic anovulation. C-reactive protein (CRP), released by adipocytes, plays a key role in PCOS. Apis mellifera honeybee venom (HBV) contains a variety of biologically active components with various pharmaceutical properties. This study was designed to assess the possibility of HBV application as an anti-inflammatory therapeutic agent. To induce PCOS, 1 mg/100 g body weight estradiol valerate (EV) was subcutaneously (SC) injected into eight-week-old rats. After 60 days, 0.5 mg/kg HBV was administered SC for 14 consecutive days, and the results of PCOS treatment were investigated. Rats were then anesthetized with chloroform, and their ovaries and livers were surgically removed to determine histomorphometrical changes. Testosterone and 17-β-estradiol were detected by chemiluminescence immunoassay. In order to detect serum CRP, ELISA kit was used in three groups of EV-induced PCOS, HBV-treated PCOS and control animals. Thickness of the theca layer, number of cysts and the level of serum CRP significantly decreased in HBV group in comparison with PCOS group. Moreover, corpus luteum, as a sign of ovulation, was observed in HBV-treated ovaries which were absent in PCOS group. Our results suggest that the beneficial effect of HBV may be mediated through its inhibitory effect on serum CRP levels.(AU)
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Animals , Rats , Bee Venoms , C-Reactive Protein , Estradiol , Ovarian FollicleABSTRACT
0.05). ② Significantly positive correlation was found between serum testosterone and fasting insulin (r=0.693, P
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OBJECTIVE: To investigate the association of genetic background between MTHFR C677T genotype and infertile females with polycystic ovarian syndrome. MATERIALS AND METHODS: We compared 86 infertile females with polycystic ovarian syndrome (PCOS) with 100 healthy fertile females with one or more offspring. Pyrosequencing analysis for MTHFR C677T variation was performed on polymerase chain reaction (PCR) product of study group. To validate pyrosequencing data of C677T variation for randomly selected 50 samples, we compared the pyrosequencing result with the PCR-RFLP (Restriction Fragment Length Polymorphism) result of MTHFR C677T genotype. RESULTS: The prevalence of the C677T mutant homozygous (TT) was significantly lower (p=0.0085) in females with PCOS (8.14%) than in fertile females (21.00%). MTHFR 677 TT genotype had a decreased risk (3.7-fold) of PCOS compared with wild type (MTHFR 677 CC). CONCLUSION: Our data support a role for MTHFR mutant homozygous (677 TT) genotype in reducing risk in Korean infertile females with Polycystic ovarian syndrome.