ABSTRACT
Objective To observe the clinical efficacy and safety of Sangxing Zhike Prescription in treating postinfectious cough(PIC)of warm dryness invading the lung type.Methods A total of 66 PIC patients with warm dryness invading the lung type who were admitted to the First Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2020 to June 2022 were randomly divided into a treatment group and a control group,with 33 patients in each group.The treatment group was given Sangxing Zhike Prescription combined with Compound Methoxyphenamine Capsules,and the control group was given Compound Methoxyphenamine Capsules combined with Chinese medicine placebo.The course of treatment covered 7 days.The changes in the Visual Analogue Scale(VAS)scores of the severity of cough,the scores of cough symptom,and the scores of traditional Chinese medicine(TCM)syndrome in the two groups were observed before and after the treatment.After treatment,the clinical efficacy and safety in the two groups were evaluated.Results(1)During the trial,one case fell off from the treatment group and 4 cases fell off from the control group,and eventually 61 cases completed the observation,of which 32 cases were in the treatment group and 29 cases were in the control group.(2)After 7 days of treatment,the total effective rate of the treatment group was 84.38%(27/32)and that of the control group was 58.62%(17/29),and the intergroup comparison(tested by chi-square test)showed that the therapeutic efficacy of the treatment group was significantly superior to that of the control group(P＜0.05).(3)After treatment,the VAS scores of the severity of cough,and the scores of daytime cough,nighttime cough of the Cough Symptom Score Scale as well as the overall cough scores in the two groups were significantly lower than those before treatment(P＜0.05 or P＜0.01),and the reduction of the VAS scores and the overall cough symptom scores in the treatment group was significantly superior to that in the control group(P＜0.05).(4)After treatment,obvious improvement was presented in the scores of TCM symptoms of cough,throat itching,dry throat,foreign body sensation in the throat,sore throat and pharyngeal signs as well as total TCM syndrome scores in the treatment group when compared with the pre-treatment period(P＜0.01),whereas in the control group,only the scores of cough,throat itching,dry throat,and sore throat and the total TCM syndrome scores were improved compared with the pre-treatment period(P＜0.05 or P＜0.01).The post-treatment intergroup comparison showed that the treatment group was significantly superior to the control group in improving the scores of throat itching,foreign body sensation in the throat,and pharyngeal signs as well as total TCM syndrome scores(P＜0.05 or P＜0.01).(5)During the treatment process,no significant adverse reactions occurred in both groups,or no abnormal changes were shown in the safety indexes such as blood routine test,liver and kidney functions of the patients.Conclusion Sangxing Zhike Prescription combined with Compound Methoxyphenamine Capsules exerts certain effect in treating patients with PIC of warm dryness invading the lung type,and its efficacy is significantly superior to that of Compound Methoxyphenamine Capsules treatment alone with relatively high safety profile.
ABSTRACT
Cough is an important complaint of respiratory disease and normal defense mechanism of the lungs. It helps in clearing excessive secretions, fluids, infections or foreign material from the airway. In most of the cases, cough occurs as part of a brief, self-limiting illness. However, it can become a persistent symptom in several cases. The etiology of cough is very diverse and commonly includes environmental causes (cigarette smoke, pollutants, dust mites, etc.) and several disease entities, including both respiratory and nonrespiratory causes. Postnasal drip syndrome and postinfectious cough are the most common respiratory causes of chronic cough. The objective of this article is to highlight the importance and consequences of cough and discuss the effective diagnosis and management of upper airway cough syndrome and postinfectious cough. For this article, PUBMED was searched for studies and guidelines published in the English language using the medical subject heading terms cough, causes of cough, etiology of cough, postinfectious cough, post-viral cough, upper airway cough syndrome, and postnasal drip.
ABSTRACT
Objective: Bakumondo-to (Mai men dong tang, B), a traditional Chinese blended medicine, has notable antitussive activity in bronchitic guinea-pigs. In this study, we examined whether or not B was effective in treating postinfectious cough.<br>Methodology: Consenting, non-smoking patients who met the following diagnostic criteria were selected as subjects: (1) those who had been coughing continuously for more than two weeks postinfectiously; (2) who did not use angiotensin-converting enzyme (ACE) inhibitors orally; (3) who had no history of nasal and/or paranasal disease, chronic pulmonary disease, atopy or gastroesophageal reflux disease; and (4) who had normal chest X-rays, respiratory function, peripheral eosinophil counts, levels of C-reactive protein, and serum IgE concentrations. Subjects were randomized into two groups: those given a daily dose of 9g of B extract granules orally for one week, and those given a daily dose of 60mg dextromethorphan hydrobromide (D) orally for one week. Using a cough diary (in which cough was scored from 0 to 9 points), we compared and studied the antitussive effects between the two groups.<br>Results: Group B was comprised of thirteen patients, and Group D, twelve. There were no significant differences between the two groups with respect to age, sex, cough scores at the time of hospital visits, duration of continuous coughing, and test results. Significant antitussive effects were seen in both groups. However, cough scores decreased significantly from the second day for the B group, and on the third, sixth and seventh day for the D group. Compared with the D group subjects, those in the B group showed higher antitussive effects on the second days (P<0.05). No serious side effects were observed for either group.<br>Conclusion: In this randomized open trial, we concluded that Bakumondo-to is an effective treatment in non-smoking patients with postinfectious cough, and it appears to demonstrate an antitussive action immediately after administration.