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Objective:To analyze effects of ozone bath, 1∶8 000 potassium permanganate bath and 1∶5 000 potassium permanganate bath on the recovery of skin lesions in patients with pemphigus.Methods:Patients with pemphigus, who received immersion bath treatment during their hospitalization, were retrospectively collected from Department of Dermatology, Peking University First Hospital from January 2016 to June 2021. The efficacy and safety of different immersion bath methods including ozone bath, 1∶8 000 potassium permanganate bath and 1∶5 000 potassium permanganate bath were compared. Categorical variables were compared using chi-square test or Fisher′s exact test, and univariate and multivariate logistic regression models were used to analyze relationships between candidate variables and patients′ condition at discharge.Results:A total of 74 patients with pemphigus were included, including 45 (60.81%) males and 29 (39.19%) females, their age ( M[ Q1, Q3]) was 52 (41, 60) years, and the median percentage of primary skin lesion area in body surface area was 40%. There were no significant differences in hospital stays, disease duration (time from onset to admission) , gender ratio or skin lesion areas among patients receiving ozone bath (32 cases) , patients receiving 1∶8 000 potassium permanganate bath (25 cases) and those receiving 1∶5 000 potassium permanganate bath (17 cases, all P > 0.05) . These patients still received other treatments, including glucocorticoids, gamma globulin, plasma transfusion, rituximab, immunosuppressants, topical antibiotics, etc., and there was no significant difference in the proportions of patients using the above therapies among the three groups (all P > 0.05) , while the ozone bath group showed a lower proportion of patients using systemic antibiotics compared with the two potassium permanganate bath groups (both P < 0.01) . At discharge, in the ozone bath group, 1 case was improved, 21 were nearly cured, and 10 were cured; in the 1∶8 000 potassium permanganate bath group, 4 cases were improved, 13 were nearly cured, and 8 were cured; in the 1∶5 000 potassium permanganate bath group, 5 were improved, 8 were nearly cured, and 4 were cured. The proportion of well-recovered patients was significantly higher in the ozone bath group (31/32 cases) than in the potassium permanganate bath group (33/42 cases, P = 0.036) . Univariate and multivariate analyses showed that ozone bath significantly affected the patients′ condition at discharge ( P < 0.05) , and was an independent predictor of "good recovery" at discharge ( HR = 8.455, 95% CI: 1.011 - 70.672, P = 0.049) . Conclusion:Ozone bath therapy can facilitate recovery of skin lesions in patients with pemphigus.
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Objective@#To establish a continuous flow injection analysis with potassium permanganate for determination of oxygen consumption in water.@*Methods@#The water samples and acid potassium permanganate working solutions were mixed using the continuous flow bubble spacing, and subjected to online heating reaction at 97 ℃. The peak height of the electrical signal of potassium permanganate was measured at the maximum absorption wavelength of 520 nm, and the standard substance, sulfuric acid concentration and potassium permanganate concentration were optimized according to the peak height of the electrical signal. The standard curve was plotted to measure the limit of detection, the limit of quantification, and spiked recovery rate of the method. The CODMn concentration was determined in 40 drinking water samples using acid potassium permanganate titration and continuous flow injection analysis using potassium permanganate, and the determination results of the two methods were compared with paired t-test.@*Results@#Glucose was selected as the standard substance, and the mixture of 17.5% sulfuric acid and 3.2 mmol/L potassium permanganate was selected as the working solution. CODMn had a good linear relationship at concentrations of 0 to 6.00 mg/L, with a correlation coefficient of 0.999 and higher, a detection limit of 0.013 mg/L and a quantitation limit of 0.043 mg/L, respectively. The spiked recovery rates were 90.00% to 105.00% in 40 drinking water samples, with relative standard deviations of 0.12% to 1.36%. The determination results of two permanganate index standard substances were all within the range of standard values. The relative errors of CODMn concentration were 1.55% to 9.26% between the continuous flow injection analysis using potassium permanganate and acid potassium permanganate titration, and there was no significant difference (t=2.023, P=0.185). @*Conclusion@#The established continuous flow injection analysis with potassium permanganate is feasible for batch determination of oxygen consumption in water.
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Objective: Development and validation of a sensitive, indirect spectrophotometric kinetic method, based on oxidation-reduction reaction, using potassium permanganate, for the quantitative assay of pitavastatin calcium, a cardiovascular drug used for the treatment of hyperlipidemia. Methods: The developed spectrophotometric kinetic method is based on the ability of potassium permanganate to oxidize Pitavastatin, where, the drug solution is treated with a fixed concentration of permanganate in acidic medium, and after a specified time, the unreacted permanganate is measured at 525 nm. All variables affecting the color development have been investigated and the conditions were optimized. Different kinetic methods, including initial rate, rate constant, fixed time and fixed concentration, were applied for the determination Pitavastatin. Results: During the course of the reaction, the absorbance values, at 525 nm, related to KMnO4, decreased linearly with increasing the concentration of the drug. The reaction rate obeyed was found to be pseudo-first-order and the kinetic method used was the fixed-time method. The assay of PITA in the concentration range of 16-80 μg/ml, using the fixed time method was successfully determined with a correlation coefficient value of 0.9999. The applicability of the developed method was also demonstrated by the determination of pitavastatin in its pure form and in its pharmaceutical formulation, where, the effect of excipients has also been studied and found to have no effect. Conclusion: The developed indirect spectrophotometric kinetic method, using the fixed time method, was used for the determination of Pitavastatin in pharmaceutical tablets. This method was simple, accurate and easy to apply for routine assay and in quality control laboratories.
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In this work the use of a mobile phone as a spectrophotometer using camera resolution by installing the software (application store AAP) on the phone (i Phone 6), which analyzes the colour images (RGB) in results with a colour length where it was possible to calculate the colour value of each image representing a specific concentration of the solution under study. A calibration curve with a range of (1 × 10-3-6.25 × 10-4) mmole.L-1 using optical image analysis with the concentration of the preparation of potassium permanganate (KMnO4). A calibration curve for statistical correlation range of 0.993 (R2) was found
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Objective: To develop and validate new, selective spectrophotometric colorimetric analytical methods for the quantification of methimazole in its pure form and in its pharmaceutical preparations. Methods: Method A is based on the oxidation of methimazole with potassium permanganate in alkaline medium, the manganate ion produced was measured at λmax= 610 nm. Method B is a kinetic determination of methimazole using fixed-time method based on the oxidation of methimazole using known excess of cerium (IV) nitrate in acidic medium and assessing the unreacted Ce (IV) by adding a fixed amount of methyl orange and measuring the absorbance of the resultant solution at λmax=507 nm which is equivalent to the unreacted methyl orange. The reaction conditions and analytical parameters are investigated and optimized. Method validation was carried out according to ICH guidelines in terms of linearity, LOD, LOQ, precision, and accuracy. Results: Beer’s law is obeyed in the range of 1.50–15.00 μg/ml for method A and 0.25–3.00 μg/ml for method B. The developed methods were subjected to the detailed validation procedure. The proposed spectrophotometric methods were applied for the determination of the methimazole in its pure form and in its pharmaceutical formulation. The percentage recoveries were found to be 100.82 % and 99.85 % in the pharmaceutical formulation for the two proposed methods, respectively. Conclusion: Both developed spectrophotometric methods, considered as green analytical chemistry, were found to be novel, highly selective and can be applied for the quality control of methimazole in its pure form and in its pharmaceutical formulation based on the simplicity, applicability of the parameters, accessibility of the reagents employed and reasonably low time of analysis.
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Objective To analyze the clinical efficacy of potassium permanganate soak combined with a closed negative pressure drainage device for treatment of bone and soft tissue infection.Methods A retrospective analysis was performed of the 83 patients with bone and soft tissue infection who had been treated at Department of Orthopaedics,The Second People's Hospital of Fuzhou from July 2010 to March 2017.They were 71 males and 12 females,aged from 15 to 77 years (median,44 years).Of them,47 were subjected to soakwith 1:5,000 potassium permanganate solution and 36 to soak with 1:5,000 gentamycin solution before a negative pressure sealing drainage device was applied for them all.The 2 groups were compared in terms of complications (pain,drainage device blockage or leakage,wound bleeding,tube pressure ulcer,and new nosocomial infection),time for negative bacterial culture,time for drainage device removal,time for wound closure,healing rate and recurrence rate.Results There were no significant differences between the 2 groups in pain,drainage device blockage or leakage,wound bleeding,or tube pressure ulcer (P ＞ 0.05).The rate of new nosocomial infection was significantly lower in the potassium permanganate group (2.1％)than in the gentamicin group (13.9％).The time for negative bacterial culture,drainage device removal and wound closure in the potassium permanganate group (6 d,12 d and 18.5 ± 1.9 d,respectively) was all significantly shorter than in the gentamicin group (9 d,15 d and 20.0 ±2.2 d,respectively) (P ＜ 0.05).The healing rate for the potassium permanganate group (100％) was significantly higher than that for the gentamicin group (86.1％);the recurrence rate (0) for the former was significantly lower than that for the latter (13.9％) (P ＜ 0.05).Conclusion Potassium permanganate soak combined with a negative pressure drainage device is effective,economical,convenient and safe for the treatment of bone and sofi tissue infection,compared with gentamicin soak combined with the same device.
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Objective To study the effect of potassium permanganate flushing in adult proximal type hypospadias patients in preventing and reducing the postoperative complications.Methods 100 cases of hypospadias in adults over the age of 16 patients according to admission order and the single or double bed number,divided into the observation group (50 cases) and the control group (50 cases).The observation group used 1:10 000 concentration of potassium permanganate solution to wash the penis and scrotum incision three days post-operation,and exposed the operation area.The control group used traditional methods,with application of vaseline oil gauze to circularly bandage the area.Results The clinical symptoms of the observation group obviously improved 5 day postoperation,and the incidence of incision infection,urinary fistula also reduced 7 days postoperation,but the class A healing rate was higher compared with those of the control group.Conclusions Using 1:10 000 concentration of potassium permanganate solution for flushing in adult patients with proximal type hypospadias three days postoperatively can effectively promote the healing of the incision,and the operation method is simple,low-cost,economic and practical,which is worth being promoted.
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BACKGROUND: Potassium permanganate is used clinically as an antiseptic and antifungal agent. Ingestion of potassium permanganate may result in damage to the upper gastrointestinal tract. Burns and ulceration of the mouth, esophagus and stomach occur due to its action. Emergency endoscopy is useful to assess the severity of damage and also to guide management.METHODS: We reported a patient presenting to the emergency department after suicidal ingestion of potassium permanganate.RESULTS: After treatment, the patient was discharged home on the 7th day after admission.CONCLUSION: Early emergency endoscopy should be considered to determine the extent of upper gastrointestinal damage in the emergency department.
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Objective To evaluate the clinical effect of potassium permanganate solution in treating the infected prepuce wound. Method From July 2000 to July 2007,97 patients with infected prepuce wound from Beijing Chaoyang hospital and other hospitals, aged 3 ～ 69 years, averaging 22.6 years, were all washed with 0. 1% potassium permanganate solution for 5～10 minutes 1～3 times a day. The 8 cases with abscess were sutured when exudate disappeared and fresh granulation tissue appeared. Results For the 89 infected patients, the wound surface became clear, dry and less exudate appeared after 3～5 days and then formed scabs. They all healed in 1 to 2 weeks. The 8 cases with abscess were all healed within 1 to 2 weeks after saturation. Conclusion Potassium permanganate solution is a convenient, economic and effective method in treating the infected prepuce wound.
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OBJECTIVE:To provide recommendation for the clinic on the optimal application concentration of potassium permanganate collyria.METHODS:3different concentrations of potassium permanganate collyria were prepared,the local ir-ritation of2of which on eyes of115conjunctivitis cases receiving conjunctival sac irrigation and the effects of the3different concentrations of potassium permanganate collyria on the comfort degree,corneal epithelium and bacterial colonies before and after eye irrigation of18pairs of oculus normalis receiving conjunctival sac irrigation were observed.RESULTS:Of the total115conjunctivitis cases,98(about85%)complained to have severe irritation;8cases(about7%)felt unbearable because of the strong irritation.Degree of comfort decreased with the elevation of concentration of collyria,while failed to have any effect on corneal epithelium and the numbers of bacterial colonies before and after irrigation.CONCLUSION:The recommended concentration of100ml∶1.5mg of potassium permanganate collyria for the irrigation of conjunctival sac in the clinic.
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Objective To remove formaldehyde of the low concentration in the indoor air and purify the indoor air. Methods The concentration of formaldehyde was determined by MBTH spectrophotometry and the removal efficiency of low concentration formaldehyde in the indoor air by using sodium sulfite, sodium bisulfite, ammonium sulfate, ammonium chloride, ammonium molybdate and potassium permanganate was tested. Results As the concentration of formaldehyde was at 1 mg/L, 10 mg/L and 100 mg/L respectively, the removal rate of formaldehyde of sodium sulfite, sodium bisulfite and potassium permanganate was 15.9%, 74.7% and 93.5% respectively. On the acidity condition or alkalescence, potassium permanganate was also effective in removing of the different concentration formaldehyde was 23.8%, 74.7% and 93.5%. Ammonium molybdate and potassium permanganate could remove the formaldehyde by 25.9% and 35.7% when the concentration of formaldehyde was at 10 mg/L and 100 mg/L. Ammonium sulfate or ammonium chloride could not effectively remove the low concentration formaldehyde and the removal rate was under 7.0%. Conclusion On the acidity condition or alkalescence, potassium permanganate is effective in removing of the low concentration formaldehyde in the indoor air.