ABSTRACT
【Objective】 To analyze the risk factors of anemia in premature infants and the status of blood transfusion. 【Methods】 Clinical data of preterm infants with age ≤48 hours and hospitalization time ≥7 days, admitted to our hospital from August 2018 to July 2019, were collected. According to the Hb value, they were divided into the anemia group and the non-anemia group. The general information, disease occurrence, and treatment measures during hospitalization of the two groups were compared, and the risk factors affecting anemia were analyzed. 【Results】 A total of 169 cases were included in this study, including 88 cases in the anemia group and 81 cases in the non-anemia group. There were statistically significant differences between two groups in assisted reproduction 47(53.409) vs 33(40.741), basic Hb value 180.395(176.282, 184.508) vs 162.841(158.596, 167.085), maternal pregnancy anemia 27(30.682) vs 12(14.815), late-onset sepsis(LOS) 64(72.727) vs 31(38.272), mechanical ventilation 46(52.273) vs 10(12.346), neonatal respiratory distress syndrome(NRDS) 51(57.955) vs 26(32.099), coagulation dysfunction 27(30.682) vs 11(13.580) and average hospitalization days 31.276(26.885, 35.666) vs 15.798(14.251, 17.344), all P<0.05. Multivariate logistic results showed assisted reproduction, maternal pregnancy anemia, mechanical ventilation, coagulation dysfunction and average hospitalization days ≥20 were risk factors for preterm anemia. A total of 40 cases(23.669%) needed RBC transfusion to correct anemia during hospitalization, including 21 cases of very low birth weight infants(VLBWI). 8 patients(38.095%) received RBC transfusion ≥3 times during VLBWI hospitalization. The incidence of bronchopulmonary dysplasia(BPD) in the multiple transfusion group(≥3 times of RBC transfusion) was higher than in the non-multiple transfusion group. 【Conclusion】 Maternal anemia during pregnancy, assisted reproduction, mechanical ventilation, coagulation dysfunction and average hospitalization days are the related factors affecting the occurrence of anemia. The occurrence of BPD may be associated with multiple blood transfusions, but there is no clear evidence to prove that blood transfusion is an independent risk factor for the development of BPD, and a large sample, multi-center study is needed.
ABSTRACT
【Objective】 To explore the clinical effect of blood transfusion in children with anemia of different severity. 【Methods】 135 premature infants admitted to our hospital from January 2018 to December 2019 were selected as research subjects. They were divided into study group(n=99) and the control group(n=36) according to the presence or absence of anemia. The children in the study group were treated with red blood cell transfusion, and the vital signs, Hb, Hct and tissue oxygen saturation of the two groups were compared. 【Results】 After treatment, HR of severe anemicgroup was (118.4±9.2) times/min, which was significantly lower than that of control group as (127.1±12.4) times/min and mildanemic group as (125.7±11.5) times/min; RR of severe anemic group was (25.0±4.7) times/min, which was significantly lower than that of control group as (30.4±5.9) times/min and mild anemic group as(28.5±5.6) times/min.And the differences were statistically significant (P<0.05). After treatment, Hb in severe anemicgroup and moderate anemic group were (140.3±6.5) g/L and (147.4±7.2) g/L, respectively, and Hct in severe anemic group and moderate anemic group were (0.43±0.02) L/L and (0.46±0.02) L/L respectively, which were significantly higher than those before treatment (P<0.05). After treatment, cerebral oxygen saturation and intestinal tissue oxygen saturation of severe anemic group were (79.2±4.0)%and (80.0±4.3)%, which were significantly lower than those of control group (P<0.05). 【Conclusion】 Blood transfusion treatment can significantly improve Hb and Hct levels, as well astissue oxygen saturationof premature infants.