Benign Fibrous Histiocytoma with Cystic Change of the Femur: a Case Report

Benign fibrous histiocytoma (BFH) is a rare benign primary skeletal tumor that occurs commonly in the long bones, spine and pelvis. BFH constitutes a diagnostic challenge because it shares clinical background, radiological characteristics, and histological features with other fibrous lesions such as non-ossifying fibroma, giant cell tumor. We present a case of BFH with cystic change that occurred in the distal femur. We did not identify any case of BFH with cystic change involving the majority of the lesion that occurred in the metaepiphysis of the long bone.

Primary Bone Tumors in Hindfoot / 대한골관절종양학회지

PURPOSE: Primary bone tumors of hindfoot are uncommon compared with other locations, and there have been few large-group studies. This study was designed to analyze the characteristics and the clinical results of the primary bone tumors of hindfoot. MATERIALS AND METHODS: Forty five cases in 44 patients who have been diagnosed from 1989 to 2011 were reviewed. The minimum follow-up period was 1 year. We retrospectively reviewed the medical records and images. RESULTS: Twenty six cases were male and 18 cases were female. Mean follow-up period was 33.1 months and mean age was 25.1 years. Forty four cases were benign and 1 case was malignant. Thirty six cases occurred in calcaneus and 9 cases were in talus. The most common benign bone tumor was simple bone cyst (20 cases), followed by intraosseous lipoma (12 cases), and chondroblastoma (4 cases). In calcaneus, there were 18 cases of simple bone cyst, and 12 cases of intrasosseous lipoma. In talus, there were 3 cases of chondroblastoma, 2 cases of simple bone cyst, and 2 cases of intraossesous ganglion. Many patients with hindfoot bone tumors presented with pain, but some were found accidentally. Patients received surgical procedures, such as curettage and bone graft, open reduction and internal fixation, tumor resection, and below knee amputation. CONCLUSION: Primary bone tumors of hindfoot are rare and can be misdiagnosed as ankle sprain or contusion. Although most are benign, malignant tumors cannot be ruled out, so early diagnosis and appropriate treatment is important.

FLOW CYTOMETRIC ANALYSIS OF DNA IN BONE TUMORS USING NUCLEAR SUSPENSION / 第二军医大学学报

The types of DNA content can be divided into four groups: (1) diploids and near-diploids; (2) triploids; (3) tetraploidy and hyperploidy aneuploids; (4) biclonal DNA content.Recent studies show that measuring DNA content by flow cytometry (FCM) can be applied to most primary bone tumors in pointing out clinically relevant informations.In this study, cellular DNA content of 33 primary bone tumors was analysed by FCM.Isolated nuclear suspensions were prepared by a simple, rapid and effective method using 10% formalin-fixed and paraffin-embedded bone tumor specimens.The results showed that 10 benign (including 5 Grade I giant cell tumors of bone) and 5 histologically questionable tumors had normal DNA content (diploids or near-diploids) and that the other 7 questionable and all of the 11 malignant tumors had abnormal DNA content (aneuploids).The cell cycle distribution analysis showed that the aneuploidy tumors had higher proportion of S-phase and G2+M-phase cells than the normal ploidy tumors, indicating there were differences in proliferative activity.The method also showed that benign and low-malignant primary bone tumors were diploids or near-diploids, and high-malignant ones were aneuploids.Compared with typically pathological grading, the flow DNA analysis of bone tumors can more objectively point out their biological behavior and prognosis.