1.
Journal of Xi'an Jiaotong University(Medical Sciences)
;
(6)1982.
Article
in Chinese
| WPRIM
| ID: wpr-544651
ABSTRACT
Objective To study the effect of prodnisolone on lipopolysaccharide(LPS)-induced RANTES by microglia.Methods The microglia were incubated in MEM culture medium,and different concentrations of LPS 0,100,500,1000?g/L) or LPS(100?g/L) and prodnisolone(10?mol/L) were added into the culture medium.12h later,the amount of RANTES was measured by ELISA.Results Microglia markedly produced RANTES in response to LPS.Prodnisolone significantly reduced the production of RANTES in microglia.Conclusion Prodnisolone has an inhibitive effect on the production of chemokines such as RANTES.