Application of Non- Concentrated Proteinuria Electrophroresis in Early Diagnosis of Type 1 Diabetic Nephropathy / 实用儿科临床杂志

Objective To investigate the significance of non - concentrated proteinuria electrophroresis in early diagnosis of type 1 diabetic nephropathy(DN). Methods A total of 47 selected patients with type 1 diabetes and 30 healthy controls were recruited in the study. Fourty seven patients were divided into diabetes mellitus(DM) group and DN group based on the rate of urinary excretion of albumin. Sodium dodcyl sulfate - agarose gel electrophoresis(SDS - AGE) was used to analyze the proteinuria in patients and controls group. Results The positive ratio of urinary albumin SDS - AGE was significantly higher in DN group than in DM group and normal control(group P