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@#Objective To evaluate the diagnostic value of artificial intelligence (AI)-assisted diagnostic system for pulmonary cancer based on CT images. Methods Databases including PubMed, The Cochrane Library, EMbase, CNKI, WanFang Data and Chinese BioMedical Literature Database (CBM) were electronically searched to collect relevant studies on AI-assisted diagnostic system in the diagnosis of pulmonary cancer from 2010 to 2019. The eligible studies were selected according to inclusion and exclusion criteria, and the quality of included studies was assessed and the special information was identified. Then, meta-analysis was performed using RevMan 5.3, Stata 12.0 and SAS 9.4 softwares. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were pooled and the summary receiver operating characteristic (SROC) curve was drawn. Meta-regression analysis was used to explore the sources of heterogeneity. Results Totally 18 studies were included with 4 771 patients. Random effect model was used for the analysis due to the heterogeneity among studies. The results of meta-analysis showed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnosis odds ratio and area under the SROC curve were 0.87 [95%CI (0.84, 0.90)], 0.89 [95%CI (0.84, 0.92)], 7.70 [95%CI (5.32, 11.15)], 0.14 [95%CI (0.11, 0.19)], 53.54 [95%CI (30.68, 93.42)] and 0.94 [95%CI (0.91, 0.95)], respectively. Conclusion AI-assisted diagnostic system based on CT images has high diagnostic value for pulmonary cancer, and thus it is worthy of clinical application. However, due to the limited quality and quantity of included studies, above results should be validated by more studies.
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Purpose: This study aimed to evaluate the correlation between infrared thermal imaging-magnetic resonance imaging (MRI)-pathology of microwave ablation (MWA) of lesions in rabbit lung tumors. Materials and Methods: MR-guided MWA was performed in nine VX2 tumor-bearing rabbits. Infrared thermal imaging, postoperative MRI, and pathological presentation were obtained and analyzed. The differences between the infrared thermal imaging-MRI-pathology of MWA were compared. Results: The center of the ablated lesion exhibited a high signal on T1-Vibe, and an isointense envelope was observed; the center of the ablated lesion exhibited a low signal on fat-suppressed turbo spin-echo T2-weighted imaging (TSE-T2WI-FS) and bands of high signal surrounding it compared with before MWA. No statistically significant difference existed between the maximum diameter of the central low-signal area of the ablation zone on TSE-T2WI-FS after MWA, the high-signal area of the ablation zone on T1-Vibe after MWA, and the maximum diameter of the pathological coagulation necrosis area, as well as between the maximum diameter of the isointense signal area peripheral to the ablation zone on T1-Vibe after MWA, the high-signal area peripheral to the ablation zone on TSE-T2WI-FS, the maximum diameter at the 41°C isothermal zone on infrared thermal imaging, and the maximum diameter of the pathological thermal injury zone. Conclusions: MWA of malignant lung tumors had specific MRI characteristics that were comparable with postoperative pathology. Infrared thermal imaging combined with MRI can be used to evaluate the extent of thermal damage to lung VX2 tumors
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OBJECTIVES:: Investigating the survival of patients with cancer is vitally necessary for controlling the disease and for assessing treatment methods. This study aimed to compare various statistical models of survival and to determine the survival rate and its related factors among patients suffering from lung cancer. METHODS:: In this retrospective cohort, the cumulative survival rate, median survival time, and factors associated with the survival of lung cancer patients were estimated using Cox, Weibull, exponential, and Gompertz regression models. Kaplan-Meier tables and the log-rank test were also used to analyze the survival of patients in different subgroups. RESULTS:: Of 102 patients with lung cancer, 74.5% were male. During the follow-up period, 80.4% died. The incidence rate of death among patients was estimated as 3.9 (95% confidence [CI], 3.1 to 4.8) per 100 person-months. The 5-year survival rate for all patients, males, females, patients with non-small cell lung carcinoma (NSCLC), and patients with small cell lung carcinoma (SCLC) was 17%, 13%, 29%, 21%, and 0%, respectively. The median survival time for all patients, males, females, those with NSCLC, and those with SCLC was 12.7 months, 12.0 months, 16.0 months, 16.0 months, and 6.0 months, respectively. Multivariate analyses indicated that the hazard ratios (95% CIs) for male sex, age, and SCLC were 0.56 (0.33 to 0.93), 1.03 (1.01 to 1.05), and 2.91 (1.71 to 4.95), respectively. CONCLUSIONS:: Our results showed that the exponential model was the most precise. This model identified age, sex, and type of cancer as factors that predicted survival in patients with lung cancer.
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Female , Humans , Male , Cohort Studies , Follow-Up Studies , Incidence , Iran , Lung Neoplasms , Lung , Models, Statistical , Multivariate Analysis , Retrospective Studies , Small Cell Lung Carcinoma , Survival RateABSTRACT
Objective:To explore the application value of MSCT in diagnosis of asymptomatic SPN through DR Chest Physical Examination.Methods: A retrospective analysis of 10 cases of complete image and pathological data of DR, CT, PET/CT confirmed by surgery in asymptomatic patients with SPN.Results: Solitary pulmouary nodules were diagnosed in the 10 patients with DR during chest examination. MSCT scanning indicated 8 cases of pulmonary cancers,one case of tuberculoma and one case of pulmonary inflammatory nodule. In 8 cases of pulmonary cancers, there found lobulation(7cases), spiculate(6cases), pleural invasion sign(5cases), vascular cluster sign(one case), and air-bronchogram(one case). PET/CT scanning testified 8 cases with above medium FDG uptake and 2 cases with mild FDG uptake. Surgical pathology showed 8 cases with lung adenocarcinoma,one case with tuberculoma and one case with granulomatous inflammation.The overall accurate diagnostic rate with MSCT was 100%. Tuberculosis and lung tumors in PET/CT examination showed above moderate FDG uptake, and one case of low FDG uptak was confirmed for pulmonary cancer by histopathology.Conclusion: MSCT is the most valuable imaging equipment in examination of asymptomatic SPN. Fine scanning with image post processing techniques is significant in the diagnosis of begnign and malignant asymptomatic SPN.
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La ecoendoscopia no solo tiene aplicaciones en la gastroenterología sino en otras áreas como la neumología. A través de la ecoendoscopia podemos evaluar zonas mediastinales como la ventana aorto-pulmonar, el espacio subcarinal y la zona para-aórtica. Con el ecobroncoscopio podemos evaluar las estaciones para-traqueales, es decir, que con estos dos equipos podemos evaluar todo el mediastino y determinar el estado del cáncer pulmonar sin necesidad de realizar exámenes más invasivos como la mediastinoscopia.
The endosonography not only has applications in gastroenterology but in other areas as pneumology. The endosonography is useful to evaluate mediastinal areas like the aorto-pulmonary window, the subcarinal space and the para-aortic zone. With the ecobronchoscopy the para-tracheal spaces can be evaluated; therefore, with these two equipment the whole mediastinum can be evaluated and also a proper staging of the pulmonary cancer can be done, with no need of more invasive procedures as the mediastinoschopy.
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Humans , Endosonography , Lung Neoplasms , MediastinoscopyABSTRACT
@#Objective To analysis the reason why patients with shoulder and back pain caused by pulmonary cancer osseous metastasis were misdiagnosed.Methods A patient of pulmonary cancer with osseous metastasis who was misdiagnosed as herniation of cervical disc,shoulder and back chronic lesion were analysed and reviewed with the literature.Results The involved vertebral bodies were osteolysis or wedging,the tumor encroach in cortical bone or soft tissue could result in shoulder and back pain.Conclusion A complete history and physical examine,systemic differential diagnosis,proper radiographic examination can decrease the incidence of misdiagnosis.
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Objective To study the characteristics and differential diagnosis of obsolete pulmonary tuberculosis accompanied withperipheral lung carcinoma.Methods CT findings of obsolete pulmonary tuberculosis accompanied with peripheral lung carcioma in 20 cases were retrospectively analysed.Results In 20 patients ,12 cases were diagnosed correctly because of them with typical CT findings of peripheral lung carcinoma,while 8 cases were misdiagnosed because of atypical CT findings of lung carcinoma.Conclusion Obsolete pulmonary tuberculosis accompained with peripheral lung carcinoma is common seen,atypical lung carcnioma is easily misdiagnosed.
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Objective To describe varied features of pulmonary metastases of lung cancer on CT imaging .Methods 194 patients with pulmonary metastases of lung cancer were evaluated on CT scan , including 106 men and 88 women . The median age of the patients was 45 years ( range from 22 to 78 years ) . The histology of the lung cancer included 56 squamous carcinomas(28.9%),107 adenocarcinomas(55.2%),26 small cell carcinomas(13.4%),and 5 adenosquamous carcinomas(2.1%).Results The usual pattern of pulmonary metastases of lung cancer were parenchyma nodules. The unusual form of metastases that were mainly found in adenocarcinomas were cavitary lesions, ground-glass nodules and lesions with unusual signals including lobulated structure, spiculated margin,pleural indentation and air-bronchogram. The manifestations of lymphangial spread to intrapulmonary were extensive uneven thickening of the interlobular septa and fissures, nodular thickening of brochovascular bundles and many fine nodulars distributed along the brochovascular bundles and interlobular septa.Conclusion The manifestations of intrapulmonary metastases of lung cancer are varied morphologic features.
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The change of plasma lipid peroxide (LPO) and RBC superoxide dismutase (SOD) in 39 cases of pulmonary cancer, amongst them 20 cases with and 19 cases without supplementation of vitamin E and vitamin C, before and after the insertional chemotherapy in the brachial artery were observed. The results showed. (l)The level of plasma LPO was elevated (P05).