COMPARISON OF THE SENSITIZING EFFECT OF METRONIDA-ZOLE DERIVATIVE (CMCa) ON TUMOR BEARING MICE BETWEEN TWO FRACTIONATED RADIOTHERAPY SCHEDULES / 第二军医大学学报

The sensitizing effects of radiosensitizer CMCa on S180 bearing mice in two f rac- tionated radiotherapy schedules were compared. The restlts showed that CMCa had the sensitizing effects in both fractionated schedules. The SER value of 2F/7D schedule was higher than that of 5F/7D. The TCD50(90) dose of 2F/7D was also decreased obviously. There was a significant difference of regression coefficients of dose-response curves between the experimental group and control one. The total radiation dose which was required for disapperance of tumor in all drug treated animals was reduced. The results indicate.that radiosensitizing effect of CMCa with 2F/7D schedule is better than that with 5F/7D.